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Monthly multiple injections of leukocyte-poor platelet-rich plasma (ACP®) for knee osteoarthritis: clinical effectiveness across KL grades, dose-response plateau at four, and 24-month durability

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Background: Monthly, ultrasound-guided intra-articular injections of leukocyte-poor platelet-rich plasma (ACP®) are widely used for knee osteoarthritis (KOA), but optimal dosing and cumulative exposure remain unclear. ... ...