Host-state biomarkers and clinical factors for stratification and optimization of cell therapy trials in chronic limb-threatening ischemia: A review [0.03%]
慢性威胁肢体缺血的细胞治疗试验分层和优化的宿主状态生物标志物和临床因素：综述
Yusuke Shimizu,Edward Hosea Ntege,Naoki Matsuura et al.
Yusuke Shimizu et al.
Background: Chronic limb-threatening ischemia (CLTI) is a severe manifestation of peripheral arterial disease associated with high risks of amputation and mortality. Trials of cell-based therapies in patients unsuitable f...
Host-state biomarkers and clinical factors for stratification and optimization of cell therapy trials in chronic limb-threatening ischemia: A review [0.03%]
慢性威胁肢体缺血的细胞治疗试验分层和优化的宿主状态生物标志物和临床因素：综述
Yusuke Shimizu,Edward Hosea Ntege,Naoki Matsuura et al.
Yusuke Shimizu et al.
Background: Chronic limb-threatening ischemia (CLTI) is a severe manifestation of peripheral arterial disease associated with high risks of amputation and mortality. Trials of cell-based therapies in patients unsuitable f...
From neural development to regenerative medicine: A research journey in stem cell biology, spinal cord repair, and iPSC-based drug discovery [0.03%]
从神经发育到再生医学：干细胞生物学、脊髓修复和基于iPSC的药物发现的研究之旅
Hideyuki Okano
Hideyuki Okano
This commemorative article reflects on a research journey spanning neural development, stem cell biology, regenerative medicine, and iPSC-based drug discovery. My early work focused on RNA-mediated regulation in the nervous system, includin...
Punicalagin alleviates senile osteoporosis by inhibiting the senescence of bone mesenchymal stem cells via NRF2/HO-1 pathway [0.03%]
蒲花酸通过NRF2/HO-1信号通路抑制骨髓间充质干细胞衰老达到治疗老年性骨质疏松的作用
Yijun Wang,Yi Qin,Tianhao Wang et al.
Yijun Wang et al.
Background: The senescence and abnormal osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) are important causes of senile osteoporosis. Punicalagin (PUN), a natural polyphenol extracted from pomegran...
A matrix-adapted RNA extraction strategy for targeted RT-qPCR analysis of periodontal ligament fibroblasts cultured on human amniotic membrane scaffolds [0.03%]
一种针对人胎盘膜支架上培养的牙周韧带成纤维细胞进行靶向RT-qPCR分析的适应于芯片的RNA提取策略
Feiroz Humayara,Haslina Taib,Zurairah Berahim et al.
Feiroz Humayara et al.
Introduction: Human amniotic membrane (HAM) is a promising scaffold for periodontal tissue engineering, supporting favorable cellular responses of human periodontal ligament fibroblasts (HPDLFs). However, molecular charac...
Impact of secretome containing extracellular vesicles from human induced pluripotent stem cell-derived cardiomyocytes [0.03%]
人诱导多能干细胞源心肌细胞分泌组中含有胞外囊泡的作用机制研究
Yuki Saito,Kazuaki Takemura,Junya Aoyama et al.
Yuki Saito et al.
Introduction: Cell transplantation therapy using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) has shown promise for ischemic heart disease. Although paracrine effects mediated by the secretome ar...
CXCL12-abundant reticular cell lineage is the key source of endosteal osteoblasts and adipocytes in adult bone marrow [0.03%]
骨髓腔内成骨细胞和脂肪细胞的主要来源是CXCL12丰富的网状细胞系
Takumi Shibahara,Katsutoshi Hirose,Makoto Abe et al.
Takumi Shibahara et al.
Introduction: CXCL12-abundant reticular (CAR) cells, characterized by high expression of CXCL12, are perisinusoidal bone marrow stromal cells that establish the hematopoietic stem cell niche. Although CAR cells are postul...
Human induced pluripotent stem cell-derived cardiomyocyte patch enhances cardiac regeneration in a J2N-k hamster model of dilated cardiomyopathy [0.03%]
人诱导多能干细胞源性心肌补片在J2N-k地鼠扩张型心肌病模型心脏修复中的应用研究
Koichi Inoue,Yosuke Kugo,Takuji Kawamura et al.
Koichi Inoue et al.
Introduction: Dilated cardiomyopathy (DCM) is a major cause of heart failure with limited therapeutic options beyond heart transplantation. This study aimed to evaluated the therapeutic potential of human induced pluripot...
Design and initial evaluation of a certified committee model for review of in vivo gene therapy and related technologies, together with ex vivo gene therapy, under the act on the safety of regenerative medicine [0.03%]
再生医学安全法下的体内基因治疗及相关技术的审查委员会模型的设计与初步评估以及体外基因疗法
Hisako Katano,Kenji Konomi,Masaya Nakamura et al.
Hisako Katano et al.
Introduction: The 2024 amendment to the Act on the Safety of Regenerative Medicine expanded the Act's regulatory scope to include in vivo gene therapy and related technologies. This created a need for certified committees...
Comparison of intra-articular injectable polydactyly-derived chondrocyte sheet-minis with direct transplantation of intact polydactyly-derived chondrocyte sheets in a rat full-thickness cartilage defect model [0.03%]
比较多指来源的软骨细胞微片的关节内注射与完整多指来源的软骨细胞片直接移植在大鼠全层软骨缺损模型中的效果
Makoto Ogawa,Eriko Toyoda,Shiho Wasai et al.
Makoto Ogawa et al.
Introduction: Polydactyly-derived chondrocyte (PD) sheets are being developed as an allogeneic cell sheet therapy for cartilage defects associated with knee osteoarthritis. Although intact PD sheets can promote hyaline ca...