Sex as a biological variable in human dental pulp stem cells: An exploratory epigenomic and transcriptomic comparison [0.03%]
人牙髓干细胞的生物变量的性别差异：探索性表观基因组和转录组比较
Shuntaro Yamada,Kateřina Holomková,Niyaz Al-Sharabi et al.
Shuntaro Yamada et al.
Objective: To determine whether baseline epigenomic and transcriptional profiles of human dental pulp stem cells (DPSCs) differ by sex, and to assess sex dependence of key markers related to growth and stemness. ...
SA/HA double-network hydrogel combined with PVDF electret membrane enhances osteogenic differentiation of DPSCs and promotes mandibular bone defect repair [0.03%]
兼具PVDF驻极体膜的SA/HA双网络水凝胶促进牙髓间充质干细胞成骨分化及下颌骨缺损修复
Ke Zheng,Jingwen Xiao,Jiacheng Qian et al.
Ke Zheng et al.
Introduction: Bone tissue defects frequently occur following trauma, bone tumor resection, and orthopedic surgery. The complex local microenvironment serves as a critical factor impeding bone tissue repair. Cell-based sca...
Lpar3-mediated macrophage polarization promotes inflammatory tooth extraction socket healing and alveolar bone regeneration [0.03%]
Lpar3介导的巨噬细胞极化促进牙拔除创口炎症消退及牙槽骨再生
Na Zhang,Suhui Ji,Zhiqi He et al.
Na Zhang et al.
Background: Delayed healing of extraction sockets under inflammatory conditions, such as periodontitis, remains a common clinical challenge. Persistent inflammation and dysregulated immune responses are increasingly recog...
From production to bedside: A tiered QC framework for regulatory alignment and analytical comparability in decentralized CGT [0.03%]
从生产到床边：用于规范一致性和分析可比性的去中心化CGT分层QC框架
Sagi Nahum,Devanshi Doshi,Cris Kosnik et al.
Sagi Nahum et al.
Decentralized and point-of-care (PoC) manufacturing is reshaping cell and gene therapy (CGT) by bringing production closer to patients. This model offers advantages, including reduced vein-to-vein times, streamlined logistics, and greater f...
Investigation of cartilage modification for controlling immune reaction against xenogeneic cartilage [0.03%]
异基因软骨免疫反应的软骨修饰研究
Sakura Uto,Daisuke Mori,Tomoaki Sakamoto et al.
Sakura Uto et al.
Introduction: Allogeneic cartilages are decellularized when they are transplanted subcutaneously to avoid the immunoreaction in clinical practice. However, transplanting cartilage with chondrocytes would be beneficial bec...
Photothermal preconditioning of platelet-rich plasma: An emerging regenerative strategy [0.03%]
富血小板血浆的光热预处理：一种新兴的再生策略
Elena Sánchez-Vizcaíno Mengual,Laura Cordero,Hernán Pinto
Elena Sánchez-Vizcaíno Mengual
Meniscal engraftment of iPSC-derived cartilage particles as hyaline and fibrous cartilage in a rabbit injury model [0.03%]
人诱导多能干细胞衍生软骨颗粒作为透明软骨和纤维软骨的半月板植入在兔损伤模型中的研究
Kenjiro Okimura,Takehiko Matsushita,Yuta Nakanishi et al.
Kenjiro Okimura et al.
Introduction: Meniscal tears are associated with the development of knee osteoarthritis. The meniscus partly consists of avascular hyaline cartilage-like tissue with a low self-healing potential. Consequently, the treatme...
Long-term outcomes of middle ear regenerative therapy using cell sheet transplantation combined with tympanoplasty [0.03%]
内耳再生细胞疗法的长期疗效研究及鼓室成型术的联合应用效果
Kazuhisa Yamamoto,Tsunetaro Morino,Akira Baba et al.
Kazuhisa Yamamoto et al.
Introduction: Regenerative medicine using autologous mucosa-derived epithelial cell sheets has attracted increasing attention as a novel therapeutic strategy for reconstructing epithelial tissues. We have developed a new ...
Methodological innovations in perfusable vascular networks: Advancing high-density tissue models [0.03%]
可灌注血管网络的方法创新：推动高密度组织模型的发展
Rinki Singh,Nobuhito Mori,Yasuyuki S Kida
Rinki Singh
The development of physiologically relevant in vitro tissue models has long been constrained by the absence of a perfusable vasculature. Native organs and tumors are sustained not only by their cellular components but also by vascular netwo...
Biofabrication strategies for engineered constructs in cardiovascular tissue repair [0.03%]
心血管组织修复用工程支架的生物制造策略研究进展
Junjie Yu,Daiki Murata,Manabu Itoh et al.
Junjie Yu et al.
Cardiovascular disease remains a major cause of morbidity and mortality worldwide, necessitating a paradigm shift in treatment approaches. Biofabrication, which involves the creation of patient-specific structures for tissue repair, has eme...