SPIN.DOC induces cellular transformation of NIH3T3 normal mouse fibroblast cells [0.03%]
SPIN.DOC诱导NIH3T3正常小鼠成纤维细胞的转化
Khuraijam Mrinalini Devi,Thangjam Davis Singh,Rubismita Deka et al.
Khuraijam Mrinalini Devi et al.
SPIN.DOC was discovered as a transcriptional co-repressor of wingless related integration site (WNT) pathway. However, it has been found to be upregulated in various types of cancer, including hepatocellular carcinoma, colorectal cancer, re...
The methylation-expression correlation of autophagy-related genes in colorectal cancer patients from southern Iran [0.03%]
南伊朗结直肠癌患者自噬相关基因甲基化与表达的相关性研究
Maryam Niknam,Fakhraddin Naghibalhossaini,Seyed Vahid Hosseini et al.
Maryam Niknam et al.
Colorectal cancer (CRC), which has high mortality and increasing morbidity is a major concern worldwide. The autophagy pathway plays a crucial role in carcinogenesis and drug resistance in this disease. Epigenetic modification is one of the...
Molecular identification of KRAS, BRAF, and PIK3CA mutations in colorectal cancer patients from the Kurdistan region of Iraq [0.03%]
伊拉克库尔德地区结直肠癌患者KRAS、BRAF和PIK3CA基因突变的分子鉴定
Hamad Gihan Hamasharif
Hamad Gihan Hamasharif
Colorectal cancer (CRC) emerged due to genetic mutations that fuel tumor development and influence patient outcomes. This research investigates KRAS, BRAF, and PIK3CA mutations in Iraqi Kurdish patients to assess their biological relevance ...
A systematic in-silico functional and structural analysis reveals deleterious missense nsSNPs in the human CSF1R gene [0.03%]
系统化的计算机功能及结构分析发现人类CSF1R基因中的有害意译nsSNPs
Purvi Malhotra,Aaryan Jaitly,Harshil Walia et al.
Purvi Malhotra et al.
Colony Stimulating Factor-1 Receptor (CSF1R) is a tyrosine kinase transmembrane receptor that plays a vital role in innate immunity and neurogenesis and controls the differentiation and maintenance of most tissue-resident macrophages. CSF1R...
In silico exploring of the epigenetic factors in teratozoospermia: A focus on IGF2BP2 [0.03%]
体外探索特纳精子症的表观遗传因素：以IGF2BP2为例
Seyedeh Zahra Mousavi,Bahram Mohammad-Soltani,Morteza Hadizadeh et al.
Seyedeh Zahra Mousavi et al.
Teratozoospermia is an abnormal sperm morphology that is a common cause of male infertility. Epigenetic factors have been implicated in the regulation of gene expression in teratozoospermia, but the specific mechanisms are not fully underst...
Role of VOPP1 in regulation of Paclitaxel response and EMT process during ovarian tumor progression [0.03%]
VOPP1在卵巢肿瘤进展过程中调节帕利乌卓尔响应和上皮-间充质转化的作用
Mohammad Hossein Khajavirad,Amirhosein Maharati,Negin Taghehchian et al.
Mohammad Hossein Khajavirad et al.
Ovarian cancer (OC) is one of the most common malignancies of the genitourinary system in women that has a high mortality rate worldwide. Drug resistance and tumor relapse are the main causes of high mortality rate in OC patients. Therefore...
The importance of TP53 status in cancer therapy: The example of chronic lymphocytic leukemia [0.03%]
TP53状态在癌症治疗中的重要性——慢性淋巴细胞白血病为例
Regina Mirgayazova,Raniya Khadiullina,Elvina Gilyazova et al.
Regina Mirgayazova et al.
The TP53 gene encodes the tumor suppressor protein p53, which plays a critical role in genomic stability and cell cycle regulation. TP53 mutations are prevalent in approximately half of all human malignancies and are associated with poor cl...
Expression patterns of circRFX3 and miR-587 in colorectal cancer patients [0.03%]
结直肠癌患者中circRFX3和miR-587的表达模式
Samaneh Najafi,Zivar Salehi,Farhad Mashayekhi et al.
Samaneh Najafi et al.
Circular RNAs (circRNAs) are non-coding, single-stranded RNAs considered by their closed-loop structures. Research has established a connection between circRNAs and cancer progression. The objective of this project was to evaluate the expre...
Gene co-expression network analysis reveals relationship between leukocyte fraction and genomic instability in dedifferentiated liposarcoma [0.03%]
基因共表达网络分析揭示去分化脂肪肉瘤中白细胞分数与基因组不稳定性的关系
Mohammad Darzi,Mahdieh Shokrollahi-Barough,Elahe Nazeri et al.
Mohammad Darzi et al.
Dedifferentiated Liposarcoma (DDLPS) is one of the common subtypes of liposarcoma that is considered a highly malignant category. This study aims to investigate DDLPS through a system biology approach. The gene expression profiles and clini...
Breast cancer susceptibility is associated with Cyclin D1 single nucleotide polymorphisms in Iran: A case-control study [0.03%]
伊朗乳腺癌遗传易感性与cyclin d1单核苷酸多态性的病例对照研究
Sadaf Soleimani,Soheila Talesh Sasani,Zivar Salehi et al.
Sadaf Soleimani et al.
Breast cancer (BC) is the main cause of cancer-related death in women worldwide. We evaluated the association between the key CCND1 gene variant; rs9344 (G>A); and BC risk in Iran. In this case-control study, blood samples were obtained fro...