SH3D21 rs34416442 genetic variation is associated with pancreatic cancer patients' overall survival and their response to gemcitabine [0.03%]
SH3D21rs34416442基因多态性与胰腺癌患者总生存期及吉西他滨疗效相关性研究
Mohammad Masoudi,Negin Ahangarian,Hossein Ammarlou
Mohammad Masoudi
Pancreatic cancer remains one of the most lethal malignancies worldwide due to late diagnosis and limited therapeutic response. Gemcitabine is widely used as a first-line chemotherapeutic agent, and SH3D21 has been identified as a gemcitabi...
Staphylococcus aureus aggravates psoriasis in human keratinocytes with the assistance of IL-17A and TNF- α, along with a contribution from genes associated with skin cutaneous melanoma [0.03%]
金黄色葡萄球菌通过白介素-17A和TNF-α促进角质形成细胞患银屑病，以及与皮肤黑色素瘤相关基因的作用
Dawood Ali-Adel,Zabn Mawj-Saddam
Dawood Ali-Adel
Psoriasis patients were 4- 5 times more likely to have S. aureus colonize their skin. Psoriasis is caused by staphylococcal infection-induced keratinocyte death, which is maintained by elevated cytokine production of TNF-α and IFN-γ. The ...
Unveiling a longstanding misinterpretation: revisiting phylogenetic and morphological evidence from Arabis verna (L.) W.T.Aiton, supports the description of a monospecific taxon, Pseudoarabis A.R. Khosravi & A. Eslami-Farouji gen. nov [0.03%]
揭露长期误解：来自Arabis verna (L.) W.T.Aiton的系谱和形态证据重新审视支持Pseudoarabis A.R. Khosravi & A. Eslami-Farouji属的新描述（仅含一种物种）
Ahmad Reza Khosravi,Özlem Çetin,Atena Eslami-Farouji
Ahmad Reza Khosravi
The tribe Arabideae includes various species worldwide with ornamental features; however, it has undergone taxonomic revisions and has been reclassified into different genera. Despite the available literature, the taxonomic assignment of so...
Steroids from Talaromyces stipitatus as potential hepatocellular carcinoma inhibitors: A computational study [0.03%]
源自Talaromyces stipitatus的类固醇作为潜在的肝细胞癌抑制剂：一项计算研究
Hung Duc Nguyen
Hung Duc Nguyen
Hepatocellular carcinoma frequently exhibits evasion of apoptosis, rendering the anti-apoptotic Bcl-2 protein a pertinent therapeutic target. Steroids from Talaromyces stipitatus were evaluated as Bcl-2 inhibitors using molecular docking, m...
Linking SIRT1 gene variation and protein levels to the pathophysiology of type 2 diabetes [0.03%]
SIRT1基因变异和蛋白水平与2型糖尿病的病理生理学之间的关联研究
Hayder Hasan-Idan,Leila Kohan
Hayder Hasan-Idan
Sirtuin 1 (SIRT1), an NAD⁺-dependent deacetylase, is involved in glucose homeostasis, insulin signaling, and inflammatory regulation, making it a potential molecular target in type 2 diabetes mellitus (T2DM). This case-control study invest...
A strategic approach to genetic model selection in association studies: A practical guide [0.03%]
关联研究中遗传模型选择的战略方法——实用指南
Mostafa Saadat
Mostafa Saadat
A systematic review on the potential of modulating the IRE arm of the UPR in U87 and U251 glioblastoma cells for improved therapeutic efficacy [0.03%]
调节U87和U251胶质母细胞瘤细胞中UPR的IRE臂以改善治疗效果的系统评价
Mehdi Ghavamizadeh,Roozbeh Kiani,Fatemeh Shams et al.
Mehdi Ghavamizadeh et al.
Glioblastoma multiforme (GBM) remains the most aggressive primary brain tumor with poor prognosis and limited response to current therapies. Recent studies suggest that the unfolded protein response (UPR), particularly the inositol-requirin...
Observations and points of interest regarding bioinformatics predictions of miRNA targeting syncytin genes in endometriosis and miscarriage [0.03%]
关于生物信息学预测的miRNA靶向子宫内膜异位症和流产syncytin基因的观察与要点
Piruz Shadbash,Marzieh Bahari-Babadi
Piruz Shadbash
Molecular and Morphological evidence support the delimitation of a new genus, Hafezia gen. nov. in Arabideae (Brassicaceae) [0.03%]
分子和形态证据支持拟南芥科阿拉伯草族中一个新属（Hafezia）的建立
Ahmad Reza Khosravi,Atena Eslami-Farouji
Ahmad Reza Khosravi
Recent molecular phylogenetic analyses within the tribe Arabideae (Brassicaceae) have uncovered unresolved lineages that challenge current generic boundaries. In this study, we incorporate molecular data with morphological evidence to resol...
Therapeutic potential of 4-OH-coumarin in neuroblastoma: cellular, molecular, and epigenetic insights [0.03%]
4-羟基香豆素在神经母细胞瘤治疗中的潜力：细胞、分子和表观遗传学见解
Çağrı Öner,Halise Elif Kulakac,Damla Kolcuoğlu et al.
Çağrı Öner et al.
The effect of 4-OH-Coumarin, a warfarin derivate, on the cellular characteristics and metastasis of SH-SY5Y neuroblastoma cells and HUVEC cells was aimed to determine. After IC50 concentrations were detected wound healing and hematoxylin-eo...