Integrative computational approach to farnesyltransferase inhibition toward anti-liver cancer drug candidate from Syzygium cumini essential oils [0.03%]
计算整合方法发现两种肝癌候选药物：Syzygium cumini精油来源的法尼基转移酶抑制剂
Wira Eka Putra,Arief Hidayatullah,Diana Widiastuti et al.
Wira Eka Putra et al.
Farnesyltransferase plays a critical role in the post-translational modification of mammalian proteins, including the Ras oncogene, which is strongly associated with cancer development. Essential oils from Syzygium cumini have demonstrated ...
Juan David Bermudes-Contreras,Luis Manuel Arratia-Cortés,Maria Esther Ramírez-Moreno et al.
Juan David Bermudes-Contreras et al.
TRPV1 (Transient Receptor Potential Vanilloid 1) is a non-selective ion channel that responds to various thermal, chemical, mechanical, and ligand stimuli. It is expressed in various tissues, mainly in nociceptive neurons, adipocytes, and o...
CPUK02 sensitizes U87 glioblastoma cell lines to TMZ treatment via autophagy flux inhibition [0.03%]
CPUK02通过抑制自噬流量增强U87胶质母细胞瘤细胞系对TMZ的敏感性
Hooman Rezaie,Sanaz Dastghaib,Morvarid Siri et al.
Hooman Rezaie et al.
Adjuvant chemotherapy with TMZ (Temozolomide) does not improve the survival of patients suffering from GBM (Glioblastoma). Given the importance of autophagy and UPR (Unfolding Protein Response) in chemotherapy resistance, as well as the rol...
Prediction of microRNAs affecting the syncytin-1 (HERV-W) and syncytin-2 (HERV-FRD) genes regulation in endometriosis and miscarriage [0.03%]
预测microRNAs对子宫内膜异位症和流产中-syncytin-1(HERV-W)和-syncytin-2(HERV-FRD)基因调控的影响
Mehdi Gholami-Barzoki,Somayeh Shatizadeh-Malekshahi,Mohammad Shayestehpour et al.
Mehdi Gholami-Barzoki et al.
Abnormal expression levels of microRNAs are associated with numerous diseases in the female reproductive tract. A small subset of human endogenous retroviruses (HERVs) genes have retained open reading frames (ORFs) that serve beneficial fun...
The possibility of prognostic and functional values of the 8q24 and 20q13 chromosomal bands in colorectal cancer [0.03%]
染色体8q24和20q13区带在结直肠癌预后及功能价值的探讨
Seyed Ahmadreza Siadat
Seyed Ahmadreza Siadat
Colorectal cancer (CRC) remains a major global health concern, especially given its increasing incidence among younger individuals. While genome-wide association studies (GWAS) have identified numerous CRC-associated polymorphisms, their sp...
Analysis of amino acid residues affecting the transcriptional activity of nuclear factor Ya [0.03%]
核因子Y转录活性影响氨基酸残基的分析
Duhan Tao,Yoshinori Takeuchi,Samia Karkoutly et al.
Duhan Tao et al.
Nuclear factor Y (NF-Y) is a heterotrimeric transcription factor essential for regulating genes involved in lipid metabolism, including fatty acid synthase (Fasn). Although NF-Y activity is known to be dynamically regulated during adipocyte...
Wharton's jelly mesenchymal stem cell-derived conditioned media inhibits colon cancer cells via activating AMPK/mTOR-mediated autophagy [0.03%]
沃顿胶间充质干细胞条件培养基通过激活AMPK/mTOR介导的自噬抑制结肠癌细胞
Dian Dayer,Zahra Akbari-Jonoush,Roya Mahdavi et al.
Dian Dayer et al.
Prior studies have shown that conditioned media derived from Wharton's jelly mesenchymal stem cells (WJ-CM) have anti-cancer properties. This research investigated the impact of WJ-CM on HT-29 colorectal adenocarcinoma cells by examining au...
Genetic polymorphisms of GSTM1 and GSTT1 genes: effects on susceptibility to formaldehyde-induced hematotoxicity [0.03%]
GSTM1和GSTT1基因多态性对甲醛致血液毒性的易感性影响研究
Reza Pourbabaki,Seyed Ahmadreza Siadat,Saeed Yousefinejad et al.
Reza Pourbabaki et al.
Formaldehyde (FA) is a known human carcinogen for the upper respiratory tract. However, its hematotoxicity remains unclear. This study was performed to assess probable effects of FA on blood parameters and to determine the common polymorphi...
Artificial intelligence and genomic data privacy: Balancing innovation with security [0.03%]
人工智能与基因数据隐私：创新和安全兼顾
Leila Kohan
Leila Kohan
SPIN.DOC induces cellular transformation of NIH3T3 normal mouse fibroblast cells [0.03%]
SPIN.DOC诱导NIH3T3正常小鼠成纤维细胞的转化
Khuraijam Mrinalini Devi,Thangjam Davis Singh,Rubismita Deka et al.
Khuraijam Mrinalini Devi et al.
SPIN.DOC was discovered as a transcriptional co-repressor of wingless related integration site (WNT) pathway. However, it has been found to be upregulated in various types of cancer, including hepatocellular carcinoma, colorectal cancer, re...