Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism [0.03%]
脯氨酰羟化酶结构域酶：重要的肿瘤代谢调控因子
Ming Yang,Huizhong Su,Tomoyoshi Soga et al.
Ming Yang et al.
The hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes (PHDs) regulate the stability of HIF protein by post-translational hydroxylation of two conserved prolyl residues in its α subunit in an oxygen-dependent manner. Trans-4-...
Jessica M Osmond,Nancy L Kanagy
Jessica M Osmond
Hydrogen sulfide (H2S) has emerged as a key regulator of cardiovascular function. This gasotransmitter is produced in the vasculature and is involved in numerous processes that promote vascular homeostasis, including vasodilation and endoth...
Neil J Howell,Daniel A Tennant
Neil J Howell
The reduction or cessation of the blood supply to an organ results in tissue ischemia. Ischemia can cause significant tissue damage, and is observed as a result of a thrombosis, as part of a disease process, and during surgery. However, the...
Angela Yuen,Begoña Díaz
Angela Yuen
Intratumoral hypoxia is a common feature of solid tumors. Recent advances in cancer biology indicate that hypoxia is not only a consequence of unrestrained tumor growth, but also plays an active role in promoting tumor progression, malignan...
Betty Gardie,Melanie J Percy,David Hoogewijs et al.
Betty Gardie et al.
The transcription of the erythropoietin (EPO) gene is tightly regulated by the hypoxia response pathway to maintain oxygen homeostasis. Elevations in serum EPO level may be reflected in an augmentation in the red cell mass, thereby causing ...
Complex role of HIF in cancer: the known, the unknown, and the unexpected [0.03%]
HIF在癌症中的复杂作用：已知、未知和意外发现
Patricia Denise Tiburcio,Hyunsung Choi,L Eric Huang
Patricia Denise Tiburcio
Tumor hypoxia has long been recognized as a driving force of malignant progression and therapeutic resistance. The discovery of hypoxia-inducible transcription factors (HIFs) has greatly advanced our understanding of how cancer cells cope w...
HIF-mediated innate immune responses: cell signaling and therapeutic implications [0.03%]
缺氧诱导因子介导的先天免疫反应：细胞信号转导与治疗意义
Alison J Harris,Aa Roger Thompson,Moira Kb Whyte et al.
Alison J Harris et al.
Leukocytes recruited to infected, damaged, or inflamed tissues during an immune response must adapt to oxygen levels much lower than those in the circulation. Hypoxia inducible factors (HIFs) are key mediators of cellular responses to hypox...
Direct phosphorylation events involved in HIF-α regulation: the role of GSK-3β [0.03%]
缺氧诱导因子调节中的直接磷酸化事件：GSK-3β的功能
Daniela Mennerich,Elitsa Y Dimova,Thomas Kietzmann
Daniela Mennerich
Hypoxia-inducible factors (HIFs), consisting of α- and β-subunits, are critical regulators of the transcriptional response to hypoxia under both physiological and pathological conditions. To a large extent, the protein stability and the r...
Hypoxia-inducible factor-mediated induction of WISP-2 contributes to attenuated progression of breast cancer [0.03%]
缺氧诱导因子介导的WISP-2诱导有助于乳腺癌发展的抑制
Jerry H Fuady,Mattia R Bordoli,Irene Abreu-Rodríguez et al.
Jerry H Fuady et al.
Hypoxia and the hypoxia-inducible factor (HIF) signaling pathway trigger the expression of several genes involved in cancer progression and resistance to therapy. Transcriptionally active HIF-1 and HIF-2 regulate overlapping sets of target ...
Hypoxia and the modulation of the actin cytoskeleton - emerging interrelations [0.03%]
低氧与肌动蛋白细胞皮层动态的调节——新的相互关系展望
Anke Zieseniss
Anke Zieseniss
Recent progress in understanding the influence of hypoxia on cell function has revealed new information about the interrelationship between the actin cytoskeleton and hypoxia; nevertheless, details remain cloudy. The dynamic regulation of t...