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Hypoxia-inducible factor-mediated induction of WISP-2 contributes to attenuated progression of breast cancer

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Hypoxia and the hypoxia-inducible factor (HIF) signaling pathway trigger the expression of several genes involved in cancer progression and resistance to therapy. Transcriptionally active HIF-1 and HIF-2 regulate overlapping sets of target genes, and only few ... ...