Markers of Hypoxia Correlate with Histologic and Endoscopic Severity of Colitis in Inflammatory Bowel Disease [0.03%]
缺氧标志物与炎症性肠病结肠炎内镜和组织学严重程度的相关性研究
Edwin F deZoeten,Kayla D Battista,Steven B Colson et al.
Edwin F deZoeten et al.
Background: Inflammation results in significant shifts in tissue metabolism. Recent studies indicate that inflammation and hypoxia occur concomitantly. We examined whether circulating and tissue markers of hypoxia could s...
Hypoxia Induces Pro-Fibrotic and Fibrosis Marker Genes in Hepatocellular Carcinoma Cells Independently of Inflammatory Stimulation and the NF-κΒ Pathway [0.03%]
缺氧通过独立于炎症刺激和NF-κB通路的方式诱导肝癌细胞的促纤维化基因及纤维化标志基因表达
Eleni-Anastasia Triantafyllou,Ilias Mylonis,George Simos et al.
Eleni-Anastasia Triantafyllou et al.
Hypoxia and its key mediators hypoxia inducible Factors (HIFs) are implicated in the development of liver diseases of diverse etiologies, often in interplay with inflammatory mediators. We investigated the interplay between hypoxia and proi...
An Erythrocytosis-Associated Mutation in the Zinc Finger of PHD2 Provides Insights into Its Binding of p23 [0.03%]
PHD2锌指结构中的 erythrocytosis相关突变提供了其与p23结合的见解
Daisheng Song,Wei Guan,Lea M Coon et al.
Daisheng Song et al.
Background: Loss of function mutations in the EGLN1 gene are a cause of erythrocytosis. EGLN1 encodes for prolyl hydroxylase domain protein 2 (PHD2). PHD2 hydroxylates and downregulates hypoxia-inducible factor-2α (HIF-2...
Reperfusion Microvascular Ischemia After Prolonged Coronary Occlusion: Implications And Treatment With Local Supersaturated Oxygen Delivery [0.03%]
长时间冠状动脉阻塞后的再灌注微血管缺血：局部超饱和氧治疗的启示及治疗意义
James Richard Spears
James Richard Spears
Following a prolonged coronary arterial occlusion, heterogeneously scattered, focal regions of low erythrocyte flow are commonly found throughout the reperfused myocardium. Experimental studies have also demonstrated the presence of widespr...
Hypoxia Suppresses High Fat Diet-Induced Steatosis And Development Of Hepatic Adenomas [0.03%]
缺氧抑制高脂肪饮食诱导的肝脂变和肝腺瘤的发生发展
Nathan W Sweeney,Cecil J Gomes,Richard De Armond et al.
Nathan W Sweeney et al.
Purpose: Nonalcoholic fatty liver disease (NAFLD) is considered the most common form of silent liver disease in the United States and obesity is associated with increased risk of NAFLD. Obstructive sleep apnea (OSA) which...
Separate and combined effects of hypobaric hypoxia and hindlimb suspension on skeletal homeostasis and hematopoiesis in mice [0.03%]
低气压缺氧和后肢悬吊对小鼠骨骼稳态和造血的单独作用及联合作用
Marjorie Durand,Jean-Marc Collombet,Sophie Frasca et al.
Marjorie Durand et al.
Purpose: Bone marrow response to an organismal stress is made by orchestrating the interplay between hematopoietic stem/progenitor cells (HSPCs) and mesenchymal stromal cells (MSCs). Neither the cellular nor the molecular...
Jing Song,Xiaojuan Yang,Liang-Jun Yan
Jing Song
Type 2 diabetes is caused by persistent high blood glucose, which is known as diabetic hyperglycemia. This hyperglycemic situation, when not controlled, can overproduce NADH and lower nicotinamide adenine dinucleotide (NAD), thereby creatin...
Ascorbate modulates the hypoxic pathway by increasing intracellular activity of the HIF hydroxylases in renal cell carcinoma cells [0.03%]
抗坏血酸通过增加肾癌细胞中HIF羟化酶的活性来调节缺氧通路
Christina Wohlrab,Caroline Kuiper,Margreet Cm Vissers et al.
Christina Wohlrab et al.
Purpose: Protein levels and activity of the hypoxia-inducible transcription factors HIF-1 and HIF-2 are controlled by hydroxylation of the regulatory alpha chains. Proline hydroxylases (PHDs) target the protein for degradation via the von-H...
Aryl hydrocarbon receptor acts as a tumor suppressor in a syngeneic MC38 colon carcinoma tumor model [0.03%]
芳烃受体在同基因MC38结肠癌肿瘤模型中作为抑癌因子的作用
Poonam Yakkundi,Eleanor Gonsalves,Maria Galou-Lameyer et al.
Poonam Yakkundi et al.
Background: Aryl hydrocarbon receptor (AHR), commonly known as an environmental sensor involved in the metabolism and elimination of xenobiotic substances, is also an important modulator in the development and functioning of the immune syst...
Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens [0.03%]
感应而生：关于最简单的动物Trichoplax adhaerens的氧气感应脯氨酰羟化酶的生物物理分析
Kerstin Lippl,Anna Boleininger,Michael A McDonough et al.
Kerstin Lippl et al.
Background: In humans and other animals, the chronic hypoxic response is mediated by hypoxia inducible transcription factors (HIFs) which regulate the expression of genes that counteract the effects of limiting oxygen. Pr...