Mitochondrial unfolded protein response as a central stress-integration hub: mechanisms and implications in disease contexts [0.03%]
线粒体未折叠蛋白反应作为应激整合中心：机制及其在疾病中的影响
Yanmin Xin,Yiting He,Xingguo Liu
Yanmin Xin
The mitochondrial unfolded protein response (UPRmt) is a conserved mitochondrial stress response that is activated by mitochondrial dysfunction to maintain proteostasis. Although UPRmt has been extensively studied in aging and cancer, its r...
Tissue regeneration strategies based on mesenchymal stem cell-derived extracellular vesicles: from bench to bedside [0.03%]
基于间充质干细胞来源的细胞外囊泡的组织再生策略：从实验到临床
Shi-Han Mu,Rang Li,Peng-Fei Wang et al.
Shi-Han Mu et al.
Regenerative medicine is undergoing a paradigm shift from live-cell therapies to cell-free strategies. Within this evolving field, mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as a leading platform. These nano...
Spatiotemporal decoding of skin biology: development, aging, disease, and regeneration [0.03%]
皮肤生物学的时空解码：发育、衰老、疾病与再生
Xinran Ding,Runzhi Huang,Yixu Li et al.
Xinran Ding et al.
Skin shows distinct temporal dynamics and spatial heterogeneity during development, aging, disease, and regeneration. Although single-cell sequencing has revealed cellular diversity, its lack of spatial context limits the ability to charact...
Bio-enhanced silk fibroin-based scaffolds for chronic diabetic foot ulcers [0.03%]
用于糖尿病慢性足部溃疡的生物增强型丝素蛋白基支架
Victoria Cubina Lopez,Jewelia Durant,Katherine R Hixon
Victoria Cubina Lopez
Diabetic foot ulcers (DFUs) represent a growing clinical challenge, driven by an aging global population and the increasing prevalence of diabetes. Affecting millions worldwide, DFUs remain one of the most serious complications of diabetes,...
Application and prospects of organoid-on-a-chip in research on the intestinal mucosal barrier [0.03%]
器官芯片在肠道黏膜屏障研究中的应用及展望
Kun Qian,Yiwen Wang,Ran Li et al.
Kun Qian et al.
The integrity of the intestinal mucosal barrier is essential for maintaining normal gut physiology, and its disruption is associated with a wide range of conditions, including trauma- and burn-related intestinal injury, which remain difficu...
Targeting the Jun-Irf8-CD36 axis attenuates fibrotic scar formation and promotes functional recovery after spinal cord injury [0.03%]
靶向Jun-Irf8-CD36轴减轻脊髓损伤后的纤维化瘢痕形成并促进功能恢复
Min Feng,JiYu Li,Jieying Zhang et al.
Min Feng et al.
Background: Fibrotic scar formation constitutes a significant pathological obstacle that impedes neural regeneration and long-term functional recovery following spinal cord injury (SCI). However, the spatial distribution ...
Adipose-derived stem cell peptide 5 alleviates hypertrophic scarring through targeting pyruvate carboxylase or p50 to coordinate PI3K/AKT/mTOR-autophagy and NF-κB/IL-6 signaling [0.03%]
人脂肪源性干细胞衍生五肽通过靶向丙酮酸羧化酶或p50缓解瘢痕过度增生的分子机制研究
Ling Chen,Enyuan Zhang,Siqi Zeng et al.
Ling Chen et al.
Background: Hypertrophic scars are a major clinical challenge with limited treatments. Adipose-derived stem cells (ADSCs) play an important role in inhibiting pathological scar formation. However, the underlying mechanism...
Spooky action at a distance: neuromodulation, physiologic distress signals, and limb preservation [0.03%]
遥距幽灵作用：神经调节、生理应激信号和肢体保存
Ahmed Sami Raihane,Gabriela Morales Deusch,Charles Liu et al.
Ahmed Sami Raihane et al.
The rising global prevalence of chronic conditions, notably obesity and type 2 diabetes, demands innovative approaches to mitigate their health and economic impacts. Complications, including neuropathy and chronic limb-threatening ischemia ...
Chuqing Zhou,Yuanli Ye,Jinrui Cai et al.
Chuqing Zhou et al.
Regenerating complex human tissues requires proper cellular assembly and the recapitulation of coordinated functions across multiple biological levels. Organoids, as self-organized three-dimensional cellular structures, provide powerful mod...