The core genetic drivers of chronological aging in yeast are universal regulators of longevity [0.03%]
酵母菌株老化的主要遗传驱动因素是长寿的通用调节因子
Erika Cruz-Bonilla,Sergio E Campos,Soledad Funes et al.
Erika Cruz-Bonilla et al.
The chronological lifespan of Saccharomyces cerevisiae has significantly contributed to our understanding of aging in eukaryotic cells. However, gaining a genome-wide perspective of this trait remains challenging due to substantial discrepa...
Organelle activity organized by the endoplasmic reticulum-mitochondria encounter structure -ERMES- is essential for Podospora anserina development [0.03%]
由内质网-线粒体相遇结构（ERMES）组织的细胞器活性对柄刀壳菌发育至关重要
Melisa Álvarez-Sánchez,Matías Ramírez-Noguez,Beatriz Aguirre-López et al.
Melisa Álvarez-Sánchez et al.
Eucaryotic cell functioning and development depend on the concerted activity of its organelles. In the model fungus Podospora anserina, sexual development involves a dynamic regulation of mitochondria, peroxisomes and the endoplasmic reticu...
The molecular mechanisms and physiological roles of mitochondria dynamics in Saccharomyces cerevisiae [0.03%]
酿酒酵母线粒体动力学的分子机制及其生理作用
Chang-Lin Chen,Wei-Ling Huang,Alexander Rapoport et al.
Chang-Lin Chen et al.
Mitochondria are essential organelles that form a dynamic network within cells. The fusion, fission, and transport processes among mitochondria must reach a balance, which is achieved through complex regulatory mechanisms. These dynamic pro...
Alternative splicing drives a dynamic transcriptomic response during Acanthamoeba castellanii programmed cell death [0.03%]
交替剪接驱动卡氏棘阿米巴程序性细胞死亡过程中的转录组动态变化
Jesús Gómez-Montalvo,Zisis Koutsogiannis,Sutherland K Maciver et al.
Jesús Gómez-Montalvo et al.
Programmed cell death (PCD) in unicellular organisms is not well characterized. This study investigated the transcriptomic response of Acanthamoeba castellanii to G418-induced PCD, focusing on the role of alternative splicing (AS). RNA sequ...
Gut microbiota and ankylosing spondylitis: current insights and future challenges [0.03%]
肠道微生物群与强直性脊柱炎：当前见解和未来挑战
Andrei Lobiuc,Liliana Groppa,Lia Chislari et al.
Andrei Lobiuc et al.
Ankylosing spondylitis (AS) is a chronic inflammatory disease with complex pathogenesis influenced by genetic, immunological and environmental factors. Recent evidence suggests that gut microbiota significantly contributes to AS etiopathoge...
Role of the putative sit1 gene in normal germination of spores and virulence of the Mucor lusitanicus [0.03%]
拟议的sit1基因在Mucor lusitanicus孢子正常萌发和致病性中的作用
Bernadett Vágó,Kitti Bauer,Naomi Varghese et al.
Bernadett Vágó et al.
Mucormycosis is a life-threatening infection caused by certain members of the fungal order Mucorales, with increased incidence in recent years. Individuals with untreated diabetes mellitus, and patients treated with deferoxamine are particu...
Tumor microenvironment signatures enhances lung adenocarcinoma prognosis prediction: Implication of intratumoral microbiota [0.03%]
肿瘤微环境标志物可增强肺腺癌预后预测：肿瘤内微生物群的启示
Fei Zhao,Lei Wang,Dongjie Du et al.
Fei Zhao et al.
The interaction between intratumoral microbiome and the tumor microenvironment (TME) has furthered our understanding of tumor ecology. Yet, the implications of their interaction for lung cancer management remain unclear. In the current work...
Persistence phenotype of adherent-invasive Escherichia coli in response to ciprofloxacin, revealing high-persistence strains [0.03%]
环丙沙星条件下黏附侵袭型大肠杆菌持续性表型的响应研究及高持续菌株的筛选
Valeria Pérez-Villalobos,Roberto Vidal,Marcela A Hermoso et al.
Valeria Pérez-Villalobos et al.
Persister cells are a subpopulation of bacteria capable of surviving antibiotic treatments and are thought to contribute to disease chronicity and symptom relapse of chronic conditions. Crohn's disease (CD) is a multifactorial chronic infla...
Knocking out histidine ammonia-lyase by using CRISPR-Cas9 abolishes histidine role in the bioenergetics and the life cycle of Trypanosoma cruzi [0.03%]
CRISPR-Cas9敲除组氨酸氨酶消除组氨酸在克查氏原虫生物能量和生活史中的作用
Janaína de Freitas Nascimento,María Julia Barisón,Gabriela Torres Montanaro et al.
Janaína de Freitas Nascimento et al.
Trypanosoma cruzi, the causing agent of Chagas disease, is the only known trypanosomatid pathogenic to humans having a complete histidine to glutamate pathway, which involves a series of four enzymatic reactions that convert histidine into ...
Dissecting the cell cycle regulation, DNA damage sensitivity and lifespan effects of caffeine in fission yeast [0.03%]
啤酒酵母细胞周期调控、DNA损伤敏感性及咖啡因对寿命影响的研究
John-Patrick Alao,Juhi Kumar,Despina Stamataki et al.
John-Patrick Alao et al.
Caffeine can modulate cell cycle progression, override DNA damage checkpoint signalling and increase chronological lifespan (CLS) in various model systems. Early studies suggested that caffeine inhibits the phosphatidylinositol 3-kinase-rel...