A time-resolved high-throughput screening of fission yeast deletion mutants for oxidative stress resistance [0.03%]
氧化应激条件下通过时间分辨的高通量筛选方法筛选模式生物裂殖酵母突变体文库中的耐受株系
Mohammadtaha Pirsalehi,Rowshan Ara Islam,Kristal Ng et al.
Mohammadtaha Pirsalehi et al.
Cells typically balance growth with stress responses - growing rapidly in low stress conditions and halting growth to defend against stress or to repair stress-induced damage. While numerous genome-wide screens have identified mutants resis...
Clonal spread and environmental persistence of carbapenem-resistant high-risk Pseudomonas aeruginosa in critical-care units of a Chilean national referral center for burn and trauma patients (2022) [0.03%]
智利国家烧伤和创伤患者转诊中心重症监护室中高风险碳青霉烯耐药铜绿假单胞菌的克隆传播及环境定植(2022)
Camila Ibarra,Gustavo Araya,Alhejandra Alvarez et al.
Camila Ibarra et al.
Pseudomonas aeruginosa is an opportunistic nosocomial pathogen ranked by the World Health Organization (WHO) as a high priority for research and the development of new antimicrobial therapies. To characterize carbapenem-resistant P. aerugin...
The transcriptome of dendritic cells redraws the boundaries between pathogenicity and commensalism in yeast [0.03%]
转录组揭示了树突细胞在酵母病原性和共生性之间的界限
Lisa Rizzetto,Irene Stefanini,Stefano Nenciarini et al.
Lisa Rizzetto et al.
Our immune system is constantly exposed to fungi, but it mounts a consistent, disease-related, and species-specific inflammatory response only against a few fungal species. Most of the current understanding of fungus-host interactions is ba...
Yippee-like protein Moh1 links gene expression to metabolism and selective stress resistance in Saccharomyces cerevisiae [0.03%]
类似Yippee的蛋白Moh1在酿酒酵母中连接基因表达、代谢和选择性压力抗性
Çağla Ece Olgun,Gizem Turan Duman,Gizem Güpür et al.
Çağla Ece Olgun et al.
The Yippee-like (YPEL) proteins are a evolutionarily conserved eukaryotic family implicated in proliferation, senescence, and stress adaptation, yet their molecular functions remain poorly defined. Humans possess five paralogs (YPEL1-YPEL5)...
Fungistatic effect of sorbic acid on yeast cells via translational repression involving eIF2 [Formula: see text] phosphorylation and formation of Ded1- and eIF2B-granules [0.03%]
山梨酸通过调控翻译抑制剂eIF2[Formula: see text]磷酸化及Ded1-和eIF2B-颗粒的形成来抑制酵母细胞生长的作用机制研究
Haruka Yoshiyama,Wataru Nomura,Shingo Izawa
Haruka Yoshiyama
Sorbic acid is a lipophilic weak acid with fungistatic activity, and it has been widely used as a food preservative, along with its potassium and calcium salts. Although the fungistatic effect of sorbic acid is thought to be primarily due t...
Occlusal types shape oral microbiome stomatotypes and metabolic landscapes: A multi-omics perspective on host-microbe interaction [0.03%]
咬合类型塑造口腔微生物组及其代谢特征：关于宿主-微生物相互作用的多组学视角
Yufeng Duan,Zheng Liu,Wenting Lu et al.
Yufeng Duan et al.
Clinical studies have uncovered associations between malocclusions and bacteria-related oral diseases. However, which malocclusion drives alternations in the oral microbiome remains unclear. Here, we identified occlusal type (OT, a major ma...
Prohibitins: emerging host targets of bacteria and viruses at the plasma membrane, mitochondria, and cytoplasm [0.03%]
prohibitin：宿主的新靶标——定位于质膜、线粒体和细胞质的细菌和病毒靶点
Grecia O Rivera-Palomino,Arianne L Theiss
Grecia O Rivera-Palomino
Ubiquitously expressed Prohibitin-1 (PHB1) and Prohibitin-2 (PHB2) serve pleiotropic functions in cellular processes, including signal transduction, mitochondrial metabolism and dynamics, and lipid raft formation. Located in phospholipid-ri...
Genomic epidemiology of carbapenemase-producing Klebsiella pneumoniae circulating in a Chilean tertiary-care hospital (2021-2022): Molecular characterization, resistance-virulence convergence, and clinical associations [0.03%]
2021年至2022年智利三级医疗机构中碳青霉烯耐药肺炎克雷伯菌的基因组流行病学研究：分子特征、抗性毒力趋同进化及其临床相关性
Gustavo Araya,Alhejandra Álvarez,Carolina Arellano et al.
Gustavo Araya et al.
Klebsiella pneumoniae (Kp) is a Gram-negative bacillus responsible for approximately 10% of nosocomial bacterial infections and one-third of Gram-negative bacterial infections in hospitalized patients. The rise of multidrug-resistant and hy...
Outer membrane vesicles in Vibrio species: Roles in biofilm formation and pathogenesis [0.03%]
维氏菌属外膜囊泡在生物被膜形成和致病性中的作用
Kumari Shambhavi,Durg Vijai Singh
Kumari Shambhavi
Outer membrane vesicles (OMVs) have been increasingly recognized as common mediators of bacterial physiology in Gram-negative bacteria, including Vibrio species. The degree and function of OMV production can differ among strains and even wi...
Sugar-induced cell death (SICD) in Saccharomyces cerevisiae: insights into nitrogen-mediated rescue and apoptotic cell death pathways [0.03%]
酵母菌中的糖诱导性细胞死亡（SICD）：探讨氮介导的拯救及凋亡型细胞死亡路径的新见解
Raveena Parbhudayal,Hai-Ping Cheng
Raveena Parbhudayal
Sugar-induced cell death (SICD) is a phenomenon observed in Saccharomyces cerevisiae whereby cells rapidly lose viability in glucose-only solutions. One theory suggests that SICD occurs due to an imbalance in nitrogen and carbon, however, l...