MicroRNA-mediated regulation of hair follicle regeneration: mechanisms, delivery strategies, and translational perspectives [0.03%]
微小核糖核酸介导的毛囊再生调控：机制、递送策略与转化前景
Yuyu Deng,Kechun Hong,Mengting Xiong et al.
Yuyu Deng et al.
Hair regeneration depends on a complex interplay between the activation of hair follicle stem cells (HFSCs), maintenance of inductive capacity in the dermal papilla (DP), and the re-establishment of immune microenvironmental homeostasis. Co...
Myeloid-derived suppressor cells in colorectal cancer: mechanisms of immunosuppression, therapy resistance and therapeutic targeting [0.03%]
髓源性抑制细胞在结直肠癌中的作用：免疫抑制、治疗抵抗及靶向治疗机制
Haoyi Zhang,Wenyue Liu,Yutong Zhang et al.
Haoyi Zhang et al.
The overall response of colorectal cancer (CRC) to immune checkpoint blockade remains limited, particularly in patients with microsatellite-stable disease. One important underlying mechanism is the involvement of myeloid-derived suppressor ...
Targeting the osteoimmune microenvironment to prevent regulated chondrocyte death in osteoarthritis: therapeutic potential of natural products [0.03%]
靶向骨免疫微环境防治骨关节炎软骨细胞程序性死亡的天然药物治疗潜力研究
Ruofan Liu,Xinyang Wang,Ziheng Zhu et al.
Ruofan Liu et al.
Osteoarthritis (OA) is increasingly recognized as a whole-joint disease driven by a dysregulated osteoimmune microenvironment, rather than mere mechanical wear. Despite the high prevalence of OA, current pharmacotherapies are largely pallia...
Integrative transcriptomic and proteomic profiling reveals altered thymocyte development and microenvironment remodeling during natural thymic atrophy [0.03%]
整合转录组学和蛋白质组学分析揭示了自然胸腺萎缩过程中胸腺细胞发育和胸腺微环境重塑发生改变
Wei Lin,Fuju Sun,Haitao Pan et al.
Wei Lin et al.
Background: Age-related thymic atrophy (ARTA) is a hallmark of immunosenescence, yet the earliest thymocyte developmental checkpoints affected by increasing age and the coordinated molecular programs that drive thymic deg...
Jhommara Bautista,Sofía Ojeda-Mosquera,Camila Beltrán-Flores et al.
Jhommara Bautista et al.
Metastasis is the leading cause of cancer-related death, yet it is still interpreted largely through genetic, spatial, and microenvironmental models that treat the host as temporally uniform. Emerging evidence challenges this view by showin...
An integrated roadmap of European sea bass (Dicentrarchus labrax) spermatogenesis across the annual reproductive cycle [0.03%]
欧洲海鲈(Dicentrarchus labrax)年度生殖周期的精子发生综合路线图
Nerea Sanchis,Noelia Díaz,Mercedes Blázquez
Nerea Sanchis
European sea bass (Dicentrarchus labrax) is a seasonal marine teleost of high aquaculture value, yet a comprehensive, stage-resolved molecular description of its spermatogenic cycle has been lacking. Here, we generated an integrated histolo...
Bone marrow plasma cytokine composition indicates acute myeloid leukemia progression and treatment response [0.03%]
骨髓浆细胞因子组成反映急性髓系白血病进展和治疗反应
Qiuyu Mo,Guoran Xie,Kangle Huang et al.
Qiuyu Mo et al.
Background: The progression of acute myeloid leukemia (AML) is characterized by intricate interactions between leukemia cells and the bone marrow (BM) microenvironment. ...
Piezo1-mediated mechanotransduction and metabolic regulation in bone health: molecular mechanisms and implications for bone disorders [0.03%]
骨骼健康中的Piezo1介导的机械转导和代谢调节：分子机制及骨疾病的意义
Jianbo Feng,Changyong Ye,Yun He et al.
Jianbo Feng et al.
Bone continuously adapts to mechanical forces to maintain structural integrity, yet the molecular sensors that initiate this process have long remained undefined. The identification of the mechanosensitive ion channel Piezo1 has provided a ...
Epithelial and microenvironmental mosaicism under stress: a two-compartment model for lung cancer development in never-smokers [0.03%]
压力下的上皮和微环境镶嵌现象：从未吸烟者中肺腺癌发生发展的两阶段模型
Risa Burr
Risa Burr
The somatic mutation theory frames cancer initiation as the consequence of accumulating driver mutations. However, the widespread presence of oncogenic mutations in normal tissues and the rarity with which these clones progress to malignanc...
Sesamin attenuates atherosclerosis by alleviating vascular endothelial ferroptosis-related injury via m6A-dependent regulation of SREBF1 expression [0.03%]
sesamin通过m6A依赖性调节SREBF1表达缓解血管内皮铁死亡相关损伤从而抑制动脉粥样硬化形成
Xiaoying Chen,Guanyi Zheng,Kailong Fu et al.
Xiaoying Chen et al.
Objective: This study was designed to elucidate the molecular pathways responsible for anti-atherosclerotic effects of the traditional Chinese medicine formula Yishen Huoxue Huatan, with a focus on its key active componen...