Terezia Vcelkova,Paulina A Latos
Terezia Vcelkova
The placenta is vital for supporting embryonic development and ensuring a successful pregnancy. Its diverse functions are carried out by specialized trophoblast cell types, including the progenitor cytotrophoblast, the multinucleated syncyt...
Astrocytic gatekeeping of neural circuitry and synaptic balance in an autism mouse model: mechanistic insights beyond Gryllus bimaculatus extract-derived therapy [0.03%]
自闭症小鼠模型中星形胶质细胞对神经环路和突触平衡的控制：Gryllus bimaculatus提取物衍生疗法之外的机制见解
Haesung Lee,Ngoc Buu Tran,Sook-Jeong Lee
Haesung Lee
Background: Autism spectrum disorder (ASD) is characterized by impaired synaptic development and disrupted excitation/inhibition (E/I) balance. While neuronal mechanisms have been extensively studied, accumulating evidenc...
Mitochondrial AAA+ protease activity uncovers differential sensitivity of Drosophila blood cell lineages to systemic cues [0.03%]
线粒体AAA+蛋白酶活性揭示了果蝇血细胞系对系统信号的差异敏感性
Rajarshi Batabyal,Aman Sharma,Maneesha S Inamdar
Rajarshi Batabyal
Hematopoiesis involves balanced blood progenitor proliferation, differentiation, and death, in response to dynamic physiological cues. Previous studies have shown that Drosophila lymph gland blood progenitors reside in functionally distinct...
Role of mitochondria-associated membranes (MAMs) in inflammatory signaling: implications for acute lung injury pathogenesis [0.03%]
线粒体相关膜(MAMs)在炎症信号转导中的作用及其对急性肺损伤发病机制的影响
Huifeng Qian,Guanguan Qiu,Jianguo Xu et al.
Huifeng Qian et al.
Mitochondria-associated membranes (MAMs), the specialized contact regions linking the endoplasmic reticulum (ER) and mitochondria, have emerged as dynamic communication hubs critical for preserving cellular homeostasis. These structures are...
Correction: Tumor organoids may be more suitable for clinical personalized chemotherapeutic drug screening in lung adenocarcinoma [0.03%]
订正：肿瘤类器官可能更适合作为临床肺腺癌化疗药物筛选的模型
Wuyang Yun,Yuyu Li,Yanlei Ge et al.
Wuyang Yun et al.
[This corrects the article DOI: 10.3389/fcell.2025.1639922.]. Keywords: Clinical Prediction; chemotherapy re...
CRISPR/Cas9-mediated CH2 deletion of Fel d1 triggers transcriptomic reprogramming and disease-associated pathways in feline cells [0.03%]
基于CRISPR-Cas9技术的猫Fel d 1蛋白CH2结构域基因编辑及对细胞转录组的影响研究
Lin-Yi Qu,Fu-Shi Quan,Shu-Ming Shi et al.
Lin-Yi Qu et al.
Fel d1, the major cat allergen responsible for over 90% of human IgE-mediated allergies, has an incompletely defined physiological role. To explore its function and assess the feasibility of producing hypoallergenic cats, we knocked out the...
Extracellular vesicles in reproductive medicine: from "animal-led" to "plant-enabled" [0.03%]
生殖医学中的细胞外囊泡：从“动物引领”到“植物赋能”
Keying Pan,Wenhan Ju,Yue Wang et al.
Keying Pan et al.
Extracellular vesicles (EVs) have emerged as pivotal mediators of intercellular communication in reproductive medicine, demonstrating considerable potential for both understanding and treating reproductive disorders. By precisely regulating...
Potential diagnostic markers and therapeutic targets for periodontitis with comorbid infective endocarditis based on bioinformatics and experimental analyses [0.03%]
基于生物信息学和实验分析的伴发感染性心内膜炎牙周病潜在诊断标志物及治疗靶点
Feng Mei,Wenjie Zhang,Xinlin Wang et al.
Feng Mei et al.
Background: Periodontitis (PD) and infective endocarditis (IE) significantly impair quality of life and contribute to considerable socioeconomic burdens. Accumulating evidence supports a bidirectional interaction between ...
Acetylcholine in the gingival epithelium drives the pathogenesis of periodontitis [0.03%]
乙酰胆碱在龈上皮中的作用驱动了牙周炎的发病机制
Shihan Xu,Jiaxin Guo,Shiwen Yang et al.
Shihan Xu et al.
Background: Periodontitis is a highly prevalent chronic inflammatory disease characterized by the progressive destruction of periodontal tissues, which can lead to tooth loss and affect systemic health. This pathological ...
Dendrite glia interactions: lessons from the C. elegans amphid sense organ [0.03%]
从线虫的感觉器官看树突与胶质细胞的相互作用
Katherine C Varandas
Katherine C Varandas
Glia are critical components of the nervous system, regulating the development and function of associated neurons. While much attention has focused on interactions between glia and axons, growing evidence highlights the importance of critic...