The role of long non-coding RNAs in therapy resistance of cervical cancer and therapeutic potential [0.03%]
Zhenglin He,Hanming Hao,Xuechao Li et al.
Zhenglin He et al.
Despite significant advances in preventive and early-detection strategies, cervical cancer (CC) continues to pose a substantial clinical burden, especially when confronting the challenge of therapy-resistant or recurrent disease. Long non-c...
Th17/treg balance in Inflammatory Bowel Disease: the role of microbial, and genetic regulators in disease modulation [0.03%]
Anna Giudice,Carolina Brescia,Domenico Morano et al.
Anna Giudice et al.
Inflammatory Bowel Disease (IBD) is a chronic condition characterized by persistent mucosal inflammation driven by complex interactions among the gut microbiome, host immune genetics, and cellular metabolism. Emerging evidence highlights th...
A novel immune-related gene signature stratifies prognosis and characterizes the tumor immune microenvironment in head and neck squamous cell carcinoma [0.03%]
Pian Li,Keling Pang,Zhigang Zhou et al.
Pian Li et al.
Background: Head and neck squamous cell carcinoma (HNSCC) exhibits heterogeneous responses to immunotherapy, primarily determined by the tumor immune microenvironment (TME). Accordingly, there is an urgent need for reliab...
pH/ROS-responsive smart hydrogels for infection control and immune microenvironment modulation in chronic wound healing [0.03%]
Rui Zhang,Suk Fei Tan,Wenqin Zhang et al.
Rui Zhang et al.
Chronic wounds are characterized by persistent infection, excessive oxidative stress, and dysregulated inflammation, which together hinder tissue repair and promote non-healing states. In this context, pH/ROS-responsive hydrogels have emerg...
Ann Song,Prue Talbot
Ann Song
Introduction: The early stages of human embryonic development are challenging to study in pregnant women. Methods: A "disease-in-a-dish...
Edmund K Kwan,Justin Park
Edmund K Kwan
For more than 70 years, the somatic mutation theory (SMT) has dominated cancer biology, conceptualizing carcinogenesis as the cumulative consequence of genetic mutations, However, expanding molecular and microenvironmental evidence reveals ...
Jie Ren,Weimei Ou,Rui Gao
Jie Ren
E3 ubiquitin ligases play essential roles in catalyzing the ubiquitination process and are involved in almost all life activities of eukaryotes. RNF20 is a really interesting new gene (RING) finger E3 ubiquitin ligase and is well-known for ...
Integrating multi-omics, EWAS, and reverse network toxicology to explore environmental pollutant risks in erectile dysfunction [0.03%]
Qingtao Yang,Qi Yu,Wei Li et al.
Qingtao Yang et al.
Background: Erectile dysfunction (ED) is increasingly prevalent worldwide, arising from complex interactions between genetic susceptibility and environmental exposure. Real-world exposure involves complex chemical mixture...
Exploring the common ferroptosis-related genes and molecular mechanisms in periodontitis and systemic sclerosis via integrated bioinformatics and experimental analysis [0.03%]
Shengchao Zhang,Shengwei Yang,Cui Ge et al.
Shengchao Zhang et al.
Background: Accumulating evidence suggests reciprocal risk factors between periodontitis (PD) and systemic sclerosis (SSc). Ferroptosis, an iron-dependent and immune-related form of cell death, has been implicated in both...
Establishing a novel mouse model of tacrolimus-induced post-transplant hepatocellular carcinoma pulmonary recurrence for transplant oncology [0.03%]
建立他克莫司诱导的移植后肝细胞癌肺复发小鼠模型用于移植肿瘤学研究
Jinliang Duan,Tao Chen,Shaofeng Chen et al.
Jinliang Duan et al.
Background: Long-term immunosuppression following transplantation places recipients at a high risk of malignancy. Hepatocellular carcinoma (HCC) recurrence after transplantation poses significant challenges to long-term s...