Long-term muscarinic inhibition increases intrinsic excitability through the upregulation of A-type potassium currents in cortical neurons [0.03%]
长期毒蕈碱抑制通过上调皮层神经元A型钾电流增加固有兴奋性
Denise Riquelme,Patricia Romo-Toledo,Paula Leyton et al.
Denise Riquelme et al.
Neurons undergo a series of perturbations that alter their firing rate and synaptic transmission; however, they can adapt to keep a target level of electrical activity in the long term. Muscarinic receptor (mAChR) transmission modulates int...
Mesenchymal stem cell-derived exosome subpopulations remained consistent for 28 culture days, displaying therapeutic effects in a silicosis mouse model [0.03%]
间充质干细胞来源的外泌体亚群在28天培养过程中保持一致，并在硅肺小鼠模型中显示出治疗效果
Lina Zhang,Jing Jin,Liguang Sun et al.
Lina Zhang et al.
Introduction: The clinical translation of mesenchymal stem cell-derived exosome faces critical challenges in scalable production, subpopulation stability, and therapeutic route optimization. This study systematically addr...
Emerging roles for E3 ubiquitin ligases in neural development and disease [0.03%]
E3泛素连接酶在神经发育和疾病中的新兴作用
Maya Hale,Greg J Bashaw
Maya Hale
Neurodevelopment is an intricate process with highly regulated, overlapping stages including neuronal differentiation and axon guidance. Aberrations during these and other stages are tied to the etiology of neurodevelopmental disorders like...
Early detection of retinal and choroidal microvascular impairments in diabetic patients with myopia [0.03%]
糖尿病合并近视患者的视网膜和脉络膜微血管损害的早期检测
Yufei Wu,Jiahui Jiang,Xiaoyu Deng et al.
Yufei Wu et al.
Purpose: To evaluate and quantify diabetes-related retinal and choroid perfusion changes in individuals with and without high myopia and explore their associations with diabetes risk factors. ...
Morinda officinalis oligosaccharides attenuate mitochondria-associated ferroptosis via the NOX4/mitoGPX4 pathway in myocardial ischemia‒reperfusion injury [0.03%]
牛膝寡糖通过NOX4/线粒体GPX4途径减轻心肌缺血-再灌注损伤相关的线粒体依赖性铁死亡
Yuqiong Chen,Yuan Tian,Bo Guan et al.
Yuqiong Chen et al.
Aim: To explore the benefits of Morinda officinalis oligosaccharides (MOO) on ischemia-reperfusion (I/R) injury and the possible mechanisms involved. Meth...
Targeting fibroblasts in pathological bone formation: mechanisms and treatments [0.03%]
针对病理性骨形成中的成纤维细胞：机制和治疗
Qianyu Zhang,Qimin Song,Zeyin Li et al.
Qianyu Zhang et al.
Fibroblasts are integral to the pathological processes underlying abnormal bone formation, including heterotopic ossification (HO), ankylosing spondylitis (AS), and ossification of the posterior longitudinal ligament (OPLL). This review sum...
Biogenesis and homeostasis of mast cell lysosome related secretory granules [0.03%]
mast细胞溶酶体相关分泌泡的生物发生及稳态调节
Ronit Sagi-Eisenberg
Ronit Sagi-Eisenberg
Mast cells (MCs) are sentinel cells of the immune system that play important protective roles in innate host defenses but are also key effectors of allergic responses and chronic inflammatory diseases. Both physiological and pathophysiologi...
Integration of machine learning and bulk sequencing revealed exosome-related gene FOSB was involved in the progression of abdominal aortic aneurysm [0.03%]
机器学习和大规模测序的整合揭示参与腹主动脉瘤进展的与外泌体相关的FOSB基因
Xianlu Ma,Hongjie Zhou,Ren Wang
Xianlu Ma
Background: Abdominal aortic aneurysm (AAA), characterized by the pathological dilation of the abdominal aorta, was associated with immune response and inflammation. However, the key genes involved in the occurrence and p...
Atypical Hippo signaling network: uncovering novel insights into head and neck cancer biology and advancements in precision intervention [0.03%]
非典型Hippo信号通路：揭示头颈部癌症生物学的新见解及精准干预的进展
Pengfei Yang,Shujuan Li
Pengfei Yang
As a major global health challenge with rising incidence and poor prognosis, head and continues to impose a significant clinical burden due to its aggressive biological behavior and frequent therapeutic resistance. Within this context, the ...
Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors [0.03%]
基于细胞的高内涵SARS-CoV-2中和方法鉴定出独特的单克隆抗体和PI3K途径抑制剂
Carly R Cabel,Briana A Guzman,Elaheh Alizadeh et al.
Carly R Cabel et al.
The sudden rise of the SARS-CoV-2 virus and the delay in development of effective therapeutics for mitigation made evident a need for ways to screen compounds that can block infection and prevent further pathogenesis and spread. However, id...