Roles of RNA-binding proteins in macrophage function regulation and immunotherapy [0.03%]
RNA结合蛋白在巨噬细胞功能调控及免疫治疗中的作用
Jia Chen,Xiulin Jiang,Yixiao Yuan et al.
Jia Chen et al.
Macrophages are essential components of the innate immune system and exhibit remarkable functional plasticity, playing pivotal roles in inflammatory responses, maintenance of tissue homeostasis, and the initiation and progression of tumors ...
Integrative epigenetic and transcriptomic profiling of whole blood and fibroblasts in Hao-Fountain syndrome [0.03%]
郝-方特综合症的血液和成纤维细胞表观遗传和转录谱集成分析
Liselot van der Laan,Rob Zwart,Andrea Venema et al.
Liselot van der Laan et al.
Background: Hao-Fountain syndrome (HAFOUS) is a rare autosomal dominant neurodevelopmental disorder caused by pathogenic USP7 variants. A diagnostic blood DNA methylation episignature has been established, yet the broader...
From synapse to system: mechanistic pathways of neural signaling dysfunction in psychiatric disorders [0.03%]
从突触到系统：精神病发病的神经信号机制路径异常
Rohan Gupta,Niraj Kumar Jha,Naveen Kumar et al.
Rohan Gupta et al.
Psychiatric disorders are increasingly viewed as network-level brain diseases resulting from disruptions in neural signaling across various hierarchies, including molecular, synaptic, circuit, and systems levels. Evidence indicates that rec...
Divergent roles of circMPP6 and its parental gene MPP6 in non-small cell lung cancer [0.03%]
环状RNA circMPP6及其母源基因MPP6在非小细胞肺癌中的不同作用
Weijuan Gao,Feng Pan,Kangping Qiu et al.
Weijuan Gao et al.
Background: Circular RNAs (circRNAs) regulate cancer biology, but their relationships with parental genes remain unclear. We characterized circMPP6, derived from MPP6, and its interplay with MPP6 in non-small cell lung ca...
Restoring Ag1, an ancient regeneration gene lost in amniotes, accelerates skin healing in mice [0.03%]
恢复陆生脊椎动物丢失的古老再生基因Ag1，可加速小鼠皮肤愈合
Anastasiya V Kosykh,Elena B Zhigmitova,Nadezhda A Evtushenko et al.
Anastasiya V Kosykh et al.
Tissue and organ regeneration is a remarkable ability observed in many animal species, which has been significantly reduced or lost in several vertebrate lineages, partly due to the evolutionary loss of regeneration-associated genes. For ex...
Phosphatases in tumor cell immune escape: a perspective based on the camouflage, coercion, cytoprotection [0.03%]
肿瘤细胞免疫逃逸的磷酸酶：基于伪装、强迫和细胞保护的观点
Chencheng Zhang,Xinyue Qiu,Weidong Shi et al.
Chencheng Zhang et al.
Tumor immune evasion represents a core challenge restricting the efficacy of cancer treatment, and a deep understanding of its underlying mechanisms is crucial for developing novel immunotherapeutic approaches. This article focuses on the m...
Transcriptional coordination in multicellular lineage differentiation during lung organogenesis: deciphering the role of epithelial cells as a microenvironmental regulatory hub [0.03%]
肺器官发生过程中多细胞谱系分化中的转录协调：解码上皮细胞作为微环境调控中心的作用
Chunyan Zhang,Jin Liu,Yanxia Li et al.
Chunyan Zhang et al.
Lung development is a complex and precisely regulated process of continuously branching morphogenesis, the core of which lies in the directed differentiation of diverse cell types and the dynamic intercellular interaction network. This revi...
Mechanistic insights into cadmium-induced hepatotoxicity mediated by dysregulation of microRNA expression [0.03%]
镉通过干扰微小核糖核酸表达诱导肝毒性的机制研究
Runcen Xu,Yiming Liu,Rui Gao et al.
Runcen Xu et al.
Cadmium (Cd), a toxic heavy metal pollutant, poses a serious threat to environmental and health and exhibits pronounced hepatotoxicity. However, the underlying mechanisms-particularly those involving microRNA (miRNA) regulation-remain incom...
Insulin-like growth factor 1 receptor (IGF1R)-dependent signaling regulates blastocyst formation during early embryonic development [0.03%]
胰岛素样生长因子1受体（IGF1R）依赖性信号调节早期胚胎发育过程中囊胚的形成
Chi-Hun Park,Young-Hee Jeoung,JiTao Wang et al.
Chi-Hun Park et al.
Insulin-like growth factor 1 (IGF1) signaling is a conserved regulator of embryonic growth and survival. However, the specific role of IGF1 signaling mediated by its cognate receptor IGF1R during mammalian preimplantation development remain...
The interplay between exosomal miRNAs and cytokine networks in metabolic diseases [0.03%]
代谢性疾病中细胞外囊泡介导的miRNA和细胞因子网络的相互作用机制研究进展
Radhika Joshi,Kanika Verma,Devesh U Kapoor et al.
Radhika Joshi et al.
Exosomal microRNAs (miRNAs) are increasingly recognized as central regulators of metabolic pathways, influencing glucose homeostasis, lipid metabolism, and inflammatory responses. Their ability to mediate inter-organ communication positions...