The 2025 paradigm shift in urothelial carcinoma pharmacotherapy: from chemotherapy to ADCs and ICIs [0.03%]
2025年尿路上皮癌药物治疗的范式转变：从化疗到抗体偶联药物和免疫检查点抑制剂
Yong Liang,Duoji Zhaxi,Meng Fu et al.
Yong Liang et al.
The pharmacotherapy of urothelial carcinoma (UC) has undergone a paradigm shift from conventional chemotherapy and BCG to novel agent-based strategies, including immune checkpoint inhibitors (ICIs) and antibody-drug conjugates (ADCs), movin...
Andrew Mugler,Bumsoo Han
Andrew Mugler
Directed migration of cancer cells is crucial to tumor progression, including tumorigenesis and metastasis. During migration, cancer cells encounter complex environmental cues and must process these signals to determine their migration dire...
Tumor suppressor BAP1 emerges as a key regulator of metabolism and cell death in tumors [0.03%]
肿瘤抑制因子BAP1作为肿瘤代谢和细胞死亡的关键调节因子浮现出来
Kexin Fan,Jun Yao,Shaobo Wu et al.
Kexin Fan et al.
BRCA1-associated protein 1 (BAP1) is a deubiquitinase (DUB) localized in both the nucleus and cytoplasm and is widely recognized as a tumor suppressor. Germline and somatic alterations in BAP1 have been strongly associated with increased su...
RNA modifications in radiotherapy resistance and radiosensitization: epitranscriptomic regulation of tumor response to radiation [0.03%]
放射抵抗和放敏中的RNA修饰：辐射下肿瘤的表转录组学调控
Hongran Qin,Shuqiang Yang,Jiawei He et al.
Hongran Qin et al.
Radiotherapy (RT) remains a major treatment for solid tumors, but durable tumor control is frequently limited by adaptive DNA repair, altered cell-death thresholds, cancer stemness, metabolic plasticity, and immune escape. RNA modifications...
RSK signaling in myeloid malignancies: biology, disease dependency, and therapeutic targeting [0.03%]
髓系恶性肿瘤中的RSK信号通路：生物学特性、疾病依赖性和治疗靶向性
Gavin M Traber,Sandra E Dunn,Kathleen M Sakamoto
Gavin M Traber
Acute myeloid leukemia (AML) and related myeloid malignancies remain clinically challenging despite recent advances in molecular profiling and targeted therapy. Although recurrent oncogenic drivers have improved disease classification and i...
Gut microbiota-derived metabolites and EVs-mediated signaling in type 2 diabetes mellitus [0.03%]
肠道微生物代谢产物及外泌体介导的信号转导在2型糖尿病中的作用
Xi-Peng Chen,Jia-Qi Xu,Nan-Nan Zhang et al.
Xi-Peng Chen et al.
Type 2 diabetes mellitus is characterized by systemic insulin resistance, chronic low-grade inflammation, and progressive metabolic dysfunction. Increasing evidence identifies the gut microbiota as a central regulator of host immunometaboli...
Chinese herbal medicine-derived exosome-like nanovesicles for orthopaedic diseases: evidence, methods, and translation [0.03%]
中药衍生的类外泌体纳米囊泡在骨科疾病中的应用：证据、方法及转化研究
Yi Hang Zhu,Jia Hao Wang,Xiao Jun Zhang et al.
Yi Hang Zhu et al.
Chinese herbal medicine/medicinal plant-derived exosome-like nanovesicles (CHM/medicinal plant-derived ELNVs) are emerging as promising nanoplatforms for orthopaedic diseases because of their favorable biocompatibility, complex bioactive ca...
Young cardiac telocyte-derived exosomes rejuvenate aging hearts in rats [0.03%]
青年心脏心tel细胞源性外泌体可使年老衰竭心脏年轻化
Luocheng Lv,Yu Zhu,Yanjun Chen et al.
Luocheng Lv et al.
Background and objective: Effective clinical strategies for rejuvenating aging hearts are needed to reverse and cure aging-related pathological cardiac degeneration. The present study was designed to investigate the poten...
Regenerative strategies for surfactant deficiency in neonatal and pediatric lung disease: the role of mesenchymal stem cells and their extracellular vesicles [0.03%]
新生儿和儿童肺部疾病表面活性剂缺乏的再生策略：间充质干细胞及其细胞外囊泡的作用
Gloria Pelizzo,Valeria Calcaterra,Maria Antonietta Avanzini et al.
Gloria Pelizzo et al.
Introduction: Surfactant deficiency underlies several neonatal and pediatric lung diseases, including respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), and genetic surfactant disorders. Although advan...
Evaluation of the cellular impact of missense variants in low-density lipoprotein receptor-related protein 6 (LRP6) associated with cardiovascular diseases in HeLa and HEK293T cell lines [0.03%]
低密度脂蛋白受体相关蛋白6(LRP6)错义变异对心血管疾病影响的细胞水平评估：HeLa和HEK293T系的研究
Anjana Raj,Huda I Samha,Sally Badawi et al.
Anjana Raj et al.
Low-density lipoprotein (LDL) receptor-related protein 6 (LRP6) is crucial for the canonical wingless signaling pathway and the clearance of LDL from the bloodstream. Genetic variants in the LRP6 gene have been conclusively associated with ...