Aquatic-derived antimicrobial peptides and their strategically modified analogues as prospective anticancer therapeutics: a comprehensive systematic review of enhancement methodologies and mechanistic insights [0.03%]
来源于海洋的抗菌肽及其经策略性修饰的类似物作为有前景的抗肿瘤药物：增强方法和机制见解的全面系统综述
Jacob Wekalao,Tobias Topisia
Jacob Wekalao
Cancer remains one of the most formidable challenges in modern medicine, with conventional therapeutic modalities increasingly constrained by dose-limiting toxicities, systemic side effects, and the relentless emergence of multidrug resista...
Synthesis of new sulfoximines and sulfonimidamides derivatives as NKCC1 inhibitors [0.03%]
新型硫氧亚胺和磺亚胺衍生物作为NKCC1抑制剂的研究
Gerald Coste,Vincent Rodeschini,Pascal George et al.
Gerald Coste et al.
Introduction: The Na-K-2Cl cotransporter isoform 1 (NKCC1) regulates cell volume and ionic distribution, thereby also controlling the efficacy of neuronal GABAergic inhibition. enhanced activity of the NKCC1 chloride impo...
State-to-state approach in hypersonic thermochemical nonequilibrium flow simulations: a review [0.03%]
高超声速非平衡流数值模拟的相变方法研究综述
Xianying Chu,Wei Zhao,Hongjun Zhang et al.
Xianying Chu et al.
Thermochemical nonequilibrium flows play a critical role in shaping the aerothermal environment of hypersonic vehicles and therefore strongly influence the analysis and design of thermal protection systems (TPS). Traditional multi-temperatu...
Integrated docking-molecular dynamics, ADME-toxicity profiling, and transcriptomic validation identify oroxylin a as a TLR7-targeting flavonoid candidate in systemic lupus erythematosus [0.03%]
整合对接-分子动力学、ADME-毒性谱分析和转录组验证识别出黄芩素是系统性红斑狼疮的TLR7靶向黄酮类候选药物
Nourah Albarrak,Hanadi Albjeedi,Ebtihal Kamal et al.
Nourah Albarrak et al.
Background: Systemic lupus erythematosus (SLE) remains difficult to control despite current therapies, highlighting the need for more selective, mechanism-based treatments targeting key innate immune components such as To...
In silico drug discovery and molecular dynamics simulation for targeting neonatal pneumonia and bronchopulmonary dysplasia [0.03%]
计算药物发现和分子动力学模拟靶向新生儿肺炎和支气管肺发育不良
Xiaoqin Chen,Qian Liu,Bing Zhang
Xiaoqin Chen
Background: Neonatal pneumonia and bronchopulmonary dysplasia (BPD) are major causes of morbidity and mortality in preterm infants, driven by excessive inflammation involving the NOD-like receptor family pyrin domain-cont...
Brain-targeting lipid nanoparticles of nicotinamide mononucleotide: preparation, optimization, and characterization [0.03%]
脑靶向烟酰胺单核苷酸脂质纳米粒的制备、优化及表征研究
Yuxian Lin,Fengdong Zhao,Jinhui Wang et al.
Yuxian Lin et al.
Nicotinamide mononucleotide (NMN) has anti-inflammatory, antioxidant, and mitochondrial function-enhancing properties, which demonstrate its significant neuroprotective potential. However, its high water solubility presents challenges with ...
Study on the mechanism of TP53 degradation by SFN ubiquitination affecting locally advanced TC progression [0.03%]
硫辛酸通过诱导TP53降解影响局部进展期舌癌的机制研究
Ying Peng,Bin Liu,Ting-Ting Yang et al.
Ying Peng et al.
Aim: Revealing the molecular mechanism of metastasis of advanced thyroid cancer and transforming it into neoadjuvant targeted therapy, to get a great potential to reduce operative mortality and improve clinical prognosis ...
Position-dependent carboxyl functionalization in covalent organic frameworks for selective photocatalytic CO2 reduction [0.03%]
基于位置的羧基化共价有机框架用于选择性光催化二氧化碳还原
Jiaxin Wang,Chunqiu Han,Liqun Ye
Jiaxin Wang
Photocatalytic carbon dioxide (CO2) reduction offers a promising route for converting greenhouse gas into value-added solar fuels under mild conditions. However, the rational regulation of product selectivity, especially the directional con...
Computational QSAR and structure-based identification of plerixafor-derived PIM-1 kinase inhibitors in diffuse large B-Cell lymphoma [0.03%]
计算QSAR和基于结构的识别来寻找弥漫性大B细胞淋巴瘤中plerixafor衍生物PIM-1激酶抑制剂
Amritha Thaikkad,B Angitha,Radul R Dev et al.
Amritha Thaikkad et al.
Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common and aggressive subtype of non-Hodgkin lymphoma, with a substantial proportion of patients developing resistance to standard chemotherapy. Chromosomal ...
A highly aqueous HPLC-PDA method for the assay of gabapentin and pregabalin: applications in pharmaceutical analysis, dissolution testing, and forensic screening [0.03%]
一种用于检测加巴喷丁和普瑞巴林的高含水HPLC-PDA法：在药物分析、溶出试验及法医筛查中的应用
Fatimah M Alamri,Taher Sahlabji,Yahya M Alshehri et al.
Fatimah M Alamri et al.
Introduction: Gabapentinoids, particularly pregabalin (PGL) and gabapentin (GBP), are widely used for neurological and psychiatric conditions but are increasingly linked to misuse and forensic challenges. Their high polar...