Metal-organic frameworks-mediated reactive oxygen species modulation in the tumor microenvironment of digestive system malignancies: latest advances [0.03%]
Wei Liu,Chengxin Liu,Meng Wu et al.
Wei Liu et al.
Digestive system malignancies, such as gastric cancer (GC), colorectal cancer (CRC), and hepatocellular carcinoma (HCC), have become a major global challenge in cancer therapy. These tumors are characterized by high morbidity, strong metast...
From waste to resource: circular valorization of spent mushroom substrate into biochar and advanced materials [0.03%]
Anagha Sunil,Julia L Shamshina
Anagha Sunil
Spent mushroom substrate (SMS), also known as spent mushroom compost, is the material that is left over after a mushroom crop has been harvested. They typically contain materials like straw, sawdust, or manure, and are rich in mycelium and ...
Anthraquinone-based turn-on fluorescence probe for selective and sensitive detection of Cu2+ ions [0.03%]
Jiang-Song Jia,Hong-Lei Li,Yi-Fan Xu et al.
Jiang-Song Jia et al.
Introduction: A novel anthraquinone-hydrazone fluorescent probe (AFSA) was designed and synthesized for the selective and sensitive detection of Cu2+ ions, which is of great significance for environmental heavy metal moni...
Phytochemical profiling and multi-target pharmacological evaluation of Symphyotrichum squamatum unveils its potential as a source of antidiabetic and anti-inflammatory agents [0.03%]
Mohammed Hassan,Islam Mostafa,Ahmed M Saad et al.
Mohammed Hassan et al.
Introduction: This study aimed to thoroughly profile the phytochemicals and pharmacological properties of Symphyotrichum squamatum's aerial parts to assess its potential as a valuable source of natural therapeutic agents....
Transfer of structural units through imine exchanges, in solution or without solvent: successive transiminations, stimuli (pH)-modulated covalent switches, and mathematical models [0.03%]
Juan Ramirez,Adrian-Mihail Stadler
Juan Ramirez
Transfer of structural units through covalent constitutional (non mechanical) switches based on (bis-)imine/amine exchanges (transiminations), can reversibly be modulated by external stimuli, namely by pH changes through alternate additions...
Synthesis of mono- and di-(C-glycopyranosyl-isoxazol(in)yl) derivatives on aromatic scaffolds and their evaluation as anti-adherence agents of Candida albicans [0.03%]
基于芳香环骨架的单、双-(C-吡喃葡萄糖基-异噁唑啉基)衍生物合成及抗白色念珠菌黏附活性研究
Tímea Kaszás,Bence Szakács,Tekla Blága et al.
Tímea Kaszás et al.
The yeast Candida albicans is one of the most prevalent fungal pathogens. It induces superficial and systemic infections in immunocompromised patients. The high pathogenicity of Candida species may be related to their adherence to the host ...
SARS-CoV-2 Mpro inhibitors from Siphonostegia chinensis: an integrated biophysical and computational study [0.03%]
基于石松chinensis的SARS-CoV-2 Mpro抑制剂：生物物理和计算综合研究
Yingjie Ren,Wei Wang,Dai Zhang et al.
Yingjie Ren et al.
Background: The COVID-19 pandemic caused by SARS-CoV-2 underscores the urgent need for novel antiviral agents. Preliminary screening indicated that the traditional Chinese medicine Siphonostegia chinensis Benth. (Bei Liu ...
Predictive modeling and ranking of physicochemicals in Aegle marmelos using topological indices and multi-criteria decision-making techniques [0.03%]
基于拓扑指数和多准则决策技术的Aegle marmelos理化特性预测及排名模型研究
Aditya Narayan Bhandari,Jaganathan B
Aditya Narayan Bhandari
Aegle marmelos (Bael Patra) contains diverse bioactive phytochemicals with significant therapeutic potential. However, it is observed that systematic computational methods for their evaluation remain limited. In this study, an integrated fr...
QM/MM hybrid simulation of enzyme-Mn synergistic catalysis for quinazolinones: computational determination of activation energy and transition state [0.03%]
喹唑啉酮酶-Mn协同催化的QM/MM杂化模拟：活化能及过渡态的理论计算研究
Haotian Cao
Haotian Cao
Quinazolinone derivatives are important nitrogen-containing heterocycles widely used in antitumor agents and functional materials, but their conventional synthesis often relies on noble-metal catalysts and inefficient multistep processes wi...
Disrupting the KRAS-SOS1 protein-protein interaction: mechanistic rationale for pan-KRAS pathway suppression and combination therapy [0.03%]
靶向KRAS-SOS1蛋白-蛋白相互作用：泛KRAS通路抑制及联合用药的机制依据
Emadeldin M Kamel,Sally Mostafa Khadrawy,Mohamed A M Ali et al.
Emadeldin M Kamel et al.
Oncogenic KRAS signaling is among the most prevalent drivers in human cancer, yet durable pathway suppression has historically been limited by incomplete target coverage, toxicity constraints for downstream kinase inhibitors, and rapid adap...