Case Report: Epstein-Barr virus negative lymphoepithelioma-like cholangiocarcinoma: a rare tumor that deserves further exploration. Report of a case with distinct genomic and clinical features [0.03%]
案例报告：一种罕见的非EB病毒阳性淋巴上皮瘤样胆道癌病例报告——具有独特的临床和基因组特征
Salvatore Corallo,Chiara Milani,Alessandro Vanoli et al.
Salvatore Corallo et al.
Lymphoepithelioma-like cholangiocarcinoma (LEL-CC) is a rare variant of cholangiocarcinoma characterized by undifferentiated malignant epithelial cells and a significant lymphoid infiltrate. Due to its rarity, there is currently no establis...
Roselle B De Guzman
Roselle B De Guzman
Introduction: The incidence of early-onset lung cancer (EOLC), often defined as those that occur in adults under the age of 50, is increasing globally. Asia accounted for almost 76% of EOLC cases worldwide. This presents ...
Evolutionary dynamics of recurrent hepatocellular carcinoma under divergent immune selection pressures [0.03%]
免疫选择压力驱动的肝细胞癌复发过程中的进化动力学研究
Ankur Chakravarthy,Elisa Pasini,Xun Zhao et al.
Ankur Chakravarthy et al.
Hepatocellular carcinoma (HCC) is a highly lethal, aggressive malignancy. Little is known about the evolutionary trajectories of HCC and how clinical decision-making could be informed based on biopsies of the initial tumour. Here, we report...
Spindle cell epithelioma of the vagina with rare morphology: a case report and literature review [0.03%]
罕见形态的阴道棘细胞上皮瘤一例报告及文献复习
Xian-Bin Tang,Yuan-Gui Xu,Li Yao et al.
Xian-Bin Tang et al.
Spindle cell epithelioma of the vagina (SCEV) is a rare female genital tract neoplasm with a complex morphology and immunophenotype easily resulting in misdiagnosis. The tumor was primarily composed of spindle and epithelioid cells. In this...
Effects of immersive virtual therapy on psychological and physical wellbeing in women with breast cancer at different stages of disease and treatment conditions: an experimental comparative study [0.03%]
沉浸式虚拟疗法对乳腺癌患者心理和生理健康的功效：一项实验比较研究
Oliver Czech,Rafal Matkowski,Jakub Skórniak et al.
Oliver Czech et al.
Background: Breast cancer (BC) is the most common cancer worldwide, with rising incidence and complex treatment challanges. Patients often experience physical and psychological symptoms that negatively affect their qualit...
Integrating network pharmacology and transcriptomics to identify solasonine's anti-osteosarcoma targets and experimental validation [0.03%]
整合网络药理学和转录组学寻找索拉索尼抗成骨肉瘤靶点及实验验证
Daihao Wei,Minyu Li,Dawei Chu et al.
Daihao Wei et al.
Background: Osteosarcoma (OS) patients face the challenge of having few effective therapeutic drugs. Solasonine(SS)is an active component of TCM against OS cells. This study aims to identify the key targets of solasonine ...
A proof-of-concept study of personalized dosimetry for targeted radioligand therapy using pre-treatment diagnostic dynamic PET/CT and Monte Carlo simulation [0.03%]
基于治疗前诊断动态正电子发射断层显像/计算机断层成像和蒙特卡洛模拟的靶向放射配体治疗个性化剂量学概念验证研究
Thanh Tai Duong,Danny De Sarno,Hatim Fakir et al.
Thanh Tai Duong et al.
Purpose: Theranostics integrates diagnostic imaging (e.g., 18F-PSMA-1007 PET) with targeted radioligand therapy (TRT; e.g., 177Lu-PSMA-617), but personalized dosimetry remains challenging due to complex dose calculations....
Umbrella review of photodynamic therapy for cancer: efficacy, safety, and clinical applications [0.03%]
光动力疗法治疗癌症的系统评价：疗效、安全性及临床应用
Hanhan Chen,Honglin Li,Hui-Jie Li et al.
Hanhan Chen et al.
Background: Photodynamic therapy (PDT) can target cancers, while causing little damage to surrounding healthy tissues. Objective: To sy...
Individualization of clinical target volume delineation in eccentric nasopharyngeal carcinoma: a prospective comparative study [0.03%]
偏心型鼻咽癌临床靶区个体化勾画的前瞻性研究
Yunrui Song,Yuwei Wang,Mengqi Yang et al.
Yunrui Song et al.
Background: Clinical target volume (CTV) delineation is a major focus in radiotherapy for nasopharyngeal carcinoma (NPC) and currently lacks a universally accepted standard across treatment centers. We proposed an individ...
The curative effect analysis of simultaneous U-VATS for bilateral multiple primary early-stage lung cancers [0.03%]
同期双侧多原发早期肺癌U-VATS联合手术疗效分析
Miao Shi,Long-Fei Wang,Xue-Chi Zhang et al.
Miao Shi et al.
Background: The incidence of multiple primary lung cancers (MPLCs) has been on the rise over the past decade, yet optimal surgical strategies remain debated. This study compared perioperative outcomes and long-term qualit...