PPP2CA knockdown upregulates the expression levels of ferroptosis-related genes TFRC and ACSL4 in colorectal cancer cells by promoting mTOR phosphorylation [0.03%]
PP2Ca下调通过促进mTOR磷酸化上调结直肠癌细胞中与铁死亡相关基因TFRC和ACSL4的表达水平
Jing Cheng,Zhihan Liu,Haibo Liu et al.
Jing Cheng et al.
Colorectal cancer (CRC) is one of the most prevalent malignant tumors worldwide, with its pathogenesis tightly linked to the regulation of cell death. Ferroptosis plays a pivotal role in the initiation, progression, and treatment of CRC. In...
Pathological diagnosis experience and literature review of four cases suspected Lynch-like syndrome [0.03%]
4例疑似Lynch样综合征病例的病理诊断经验及文献复习
Bo Cheng,Shan Liu,Shanshan Ding et al.
Bo Cheng et al.
Background: Among CRC patients with mismatch repair protein deficiency or microsatellite instability (MSI), up to 50% of cases lack germline mutations in MMR genes, BRAF mutations, or MLH1 promoter methylation. Such cases...
Fengting Yan,Min Sun,Henry Kaplan
Fengting Yan
Integrated CIRCLE-seq with RNA-seq to decipher the quantity, localization, and functional features of eccDNA in AML [0.03%]
整合CIRCLE-seq和RNA-seq技术解码AML中eedna的数量、定位及功能特征
Lijuan Gao,Qiongyu Lu,Hao Li et al.
Lijuan Gao et al.
Background: Extrachromosomal circular DNA (eccDNA) plays critical roles in cancer, yet its landscape in acute myeloid leukemia (AML) remains unexplored. M...
Unveiling the traits of HER2-low breast cancer: a comparative analysis of IHC1+ vs IHC2+/ISH-negative subgroups - insights from a 3-year cohort study [0.03%]
揭开HER2低表达乳腺癌的特征：一项为期三年的队列研究中IHC1+与IHC2+/ISH阴性亚组的比较分析见解
Jorge Correia,Catarina Pulido,Joana Albuquerque et al.
Jorge Correia et al.
Background: Half of all breast cancer (BC) cases fall into the HER2-low category, defined as immunohistochemistry (IHC) 1+ or IHC 2+ in situ hybridization negative (ISH-). Two-thirds of these cases are IHC1+, while one-th...
Cutaneous adverse events associated with the efficacy and benefit of immune checkpoint inhibitors: a systematic review and meta-analysis [0.03%]
与免疫检查点抑制剂疗效和获益相关的皮肤不良事件：系统评价和-meta-分析
Li Zhang,Yunge Gao
Li Zhang
Objective: Cutaneous immune-related adverse events (cirAEs) are associated with improved survival in tumor patients undergoing immune checkpoint inhibitors (ICIs) therapy, while inconsistent evidence has been reported acr...
Downregulation of HDGF inhibits tumorigenic phenotypes of hypopharyngeal squamous cell carcinoma by suppressing the AKT/mTOR/VEGF pathway [0.03%]
HDGF通过抑制AKT/mTOR/VEGF信号通路下调来抑制下咽鳞癌的恶性表型
Feilong Yang,Qiang Zhang,Jiahao Shan et al.
Feilong Yang et al.
Background: Hypopharyngeal squamous cell carcinoma (HSCC), an aggressive HNSCC subtype characterized by high metastatic potential and poor prognosis, frequently overexpresses hepatoma-derived growth factor (HDGF), a facto...
Case Report: Pitfalls in anatomic pathology and clinical oncology: a case of misdiagnosed pulmonary Ewing sarcoma as SCLC [0.03%]
个例报告：解剖病理学和临床肿瘤学中的陷阱——一例误诊为小细胞肺癌的肺尤因肉瘤病例
Nagham S El Waary,Angelo A Chami,Jawad K Zrein et al.
Nagham S El Waary et al.
In oncology, an accurate pathological diagnosis can often mean the difference between cure and failure, potentially determining a patient's survival. We present the case of a 28-year-old, never-smoking man whose initial diagnosis of small c...
Papillary thyroid carcinoma measuring 1.0 cm or less: an epidemiological and clinicopathological study [0.03%]
直径1.0厘米或小于1.0厘米的乳头状甲状腺癌的流行病学及临床病理特征研究
Imad A El Hag,Raghad Tallab
Imad A El Hag
Background: The incidence of papillary thyroid microcarcinoma (PTMC) measuring 1 cm or less has noticeably increased over the past 30 years, particularly among clinically significant subgroups that are diagnosed chiefly p...
Correction: Co-occurrence patterns of esophageal and stomach cancer across 204 countries and territories: a spatial correspondence and systematic analysis [0.03%]
纠正：跨越204个国家和地区食管癌和胃癌共现模式的空间对应关系及系统分析
Jiayao Xu,Jiabei Gong,Huiqiong Han et al.
Jiayao Xu et al.
[This corrects the article DOI: 10.3389/fonc.2025.1613839.]. Keywords: BAPC model; age-period-cohort model; ...
Published Erratum
Frontiers in oncology. 2025 Nov 7:15:1728915. DOI:10.3389/fonc.2025.1728915 2025