Development and validation of a pathomics-driven machine learning model for individualized prediction of neoadjuvant chemotherapy response and early recurrence in HR-positive, HER2-negative breast cancer [0.03%]
基于病理组学的机器学习模型在HR阳性、HER2阴性乳腺癌新辅助化疗疗效及早期复发中的个体化预测价值
Jiaxian Yue,Jiaxiang Liu,Xiyu Kang et al.
Jiaxian Yue et al.
Background: Hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer is the most prevalent subtype among women but has a modest response to neoadjuvant chemotherapy (NAC). Acc...
Case Report: An exceptional response to a novel immunotherapy-based combination treatment for resected pancreatic ductal adenocarcinoma with recurrence to the abdominal wall [0.03%]
病例报告：新型免疫治疗联合方案成功治疗胰腺导管腺癌伴腹壁转移的病例报道
Thomas Enzler,Sara Tweedy,Isabella Holmes et al.
Thomas Enzler et al.
Pancreatic ductal adenocarcinoma (PDAC) is a difficult-to-treat cancer with a 5-year survival rate of only 13%. Intense chemotherapies are needed to control the disease. Surgical resection, if possible, is the only curative approach. Howeve...
Clinical outcomes and survival in patients with NSCLC and EGFR exon 20 mutations: evidence from real-world clinical practice in a retrospective study in Galicia [0.03%]
EGFR 20外显子突变NSCLC患者的临床转归及生存分析：一项回顾性真实世界研究的证据（加利西亚报告）
Begoña Campos Balea,Martín Emilio Lázaro Quintela,Ma Carmen Areses Manrique et al.
Begoña Campos Balea et al.
Background: Non-small cell lung cancer (NSCLC) with mutations in epidermal growth factor receptor exon 20 (EGFR Ex20Ins) is rare and resistant to conventional tyrosine kinase inhibitors (TKIs), limiting treatment options....
Association of regional specificity of blood-brain barrier permeability with pathological subtypes in cerebral white matter of patients with non-brain metastatic lung cancer [0.03%]
非脑转移肺癌患者不同病理亚型大脑白质区血脑屏障通透性的区域特异性研究
Haotian Wang,Jian Zeng,Zhengzhen Li et al.
Haotian Wang et al.
Objective: To investigate blood-brain barrier (BBB) permeability abnormalities in cerebral white matter regions of non-brain metastatic lung cancer (LC) patients and their association with histopathological subtypes. ...
Case Report: Safety analysis of blinatumomab consolidation therapy in two cases of acute B-cell lymphoblastic leukemia in complete remission complicated with immune effector cell-associated neurotoxicity syndrome [0.03%]
病例报告：免疫效应细胞相关神经毒性综合征完全缓解后的急性B淋巴细胞白血病患者使用Blinatumomab巩固治疗的安全性分析
Yixuan Ma,Luyang Chang,Ruihua Mi et al.
Yixuan Ma et al.
Background: Blinatumomab, a bispecific T-cell engager (BiTE), has significantly improved the efficacy of B-ALL treatment. However, its association with immune effector cell-associated neurotoxicity syndrome (ICANS) has ga...
Adherence to adjuvant endocrine therapy in breast cancer: a single regional Australian centre experience [0.03%]
乳腺癌辅助内分泌治疗的依从性：澳大利亚一家地区中心的经验
Dianheng Bu,Arvind Sahu,Javier Torres
Dianheng Bu
Introduction: Adjuvant endocrine therapy reduces cancer recurrence and improves overall survival in hormone receptor-positive breast cancer. Maintaining long-term adherence to endocrine therapy can be challenging, and non...
One size does not fit all: rethinking IO-TKI use in favorable-risk metastatic ccRCC [0.03%]
一刀切行不通：重新思考一线TKI在有利风险转移性透明细胞肾癌中的使用
Alejandro Valdés,Enrique Grande,Mauricio Burotto
Alejandro Valdés
Ensemble transformer-based multiple instance learning for predicting neoadjuvant chemotherapy response from breast cancer biopsy whole-slide images [0.03%]
基于Transformer的乳腺癌活检全切片图像新辅助化疗反应预测集成模型
Zhenshui Wu,Kaining Ye,Jianming Weng et al.
Zhenshui Wu et al.
Introduction: Neoadjuvant chemotherapy (NAC) is a cornerstone of breast cancer management, and accurate prediction of therapeutic efficacy is essential for optimizing treatment strategies and improving patient outcomes. ...
Arkaitz Castañeda-Babarro,Aitor Martinez Aguirre-Betolaza
Arkaitz Castañeda-Babarro
Factors associated with clinical outcomes of breast cancer based on glucose metabolic activity of subcutaneous adipose tissue [0.03%]
基于皮下脂肪组织葡萄糖代谢活性的乳腺癌临床结局影响因素分析
Jinci Mai,Huanhua Wu,Wanwan Wu et al.
Jinci Mai et al.
Background: Obesity increases the risk of breast cancer, with dysfunctional metabolic activity in subcutaneous adipose tissue (SAT) implicated as a key underlying mechanism. This study sought to explore the correlation be...