Venetoclax combined with azacitidine in the treatment of secondary myelodysplastic syndrome following multiple myeloma: a case report and literature review [0.03%]
维奈托克联合地西他滨治疗继发于多发性骨髓瘤的继发性骨髓增生异常综合征病例报道及文献回顾
Lijun Shi,Zhongrui Ma,Xia Yu et al.
Lijun Shi et al.
We conducted a retrospective analysis of the clinical data of a patient with myelodysplastic syndrome (MDS) secondary to stable multiple myeloma (MM), who was treated with a combination of venetoclax and azacitidine at the Fifth People's Ho...
Transcriptomic differences in chromatin and cell cycle regulation in A549 cells after irradiation with carbon ions and X-rays [0.03%]
碳离子和X射线照射人肺癌A549细胞后染色质和细胞周期调控的转录组差异分析
Hasan Nisar,Özdemirhan Serçin,Christine E Hellweg
Hasan Nisar
Introduction: High-linear energy transfer (LET) radiation such as carbon ions exhibits greater biological effectiveness than conventional low-LET X-rays, but the transcriptional mechanisms underlying this advantage remain...
Ferroptosis contributes to quercetin-induced anti-cancer activity through blockade of LGR4/NF-κB/GPX4 axis in oral squamous cell carcinoma [0.03%]
山柰酚通过抑制LGR4/NF-κB/GPX4轴诱导口腔鳞状细胞癌铁死亡从而发挥抗肿瘤作用
Xiao-Jiao Wang,Peng Zhang,Yue Gao et al.
Xiao-Jiao Wang et al.
Objective: Oral squamous cell carcinoma (OSCC) is a malignancy that faces challenges such as chemotherapy resistance and side effects. There is an urgent need for effective, low-toxicity compounds to treat OSCC. Here, we ...
Case Report: A unique case of Philadelphia chromosome-positive mixed-phenotype acute leukemia with active Epstein-Barr virus infection in a kidney transplantation recipient [0.03%]
病例报告：肾移植受者中Ph染色体阳性混合表型急性白血病合并EB病毒活性感染一例
Mengping Chen,Xuelian Hu,Weiying Feng et al.
Mengping Chen et al.
Philadelphia chromosome-positive (Ph+) mixed-phenotype acute leukemia (MPAL) is a rare entity of acute leukemia. The co-occurrence of Ph+ MPAL and active Epstein-Barr virus (EBV) viremia in a renal transplantation recipient represents an ex...
Artificial intelligence in the radiologic assessment of ductal carcinoma in situ: a systematic review [0.03%]
人工智能在导管原位癌放射学评估中的应用：系统性回顾
Colin Wu,Alison Bartak,Ramaswamy Sharma
Colin Wu
Ductal carcinoma in situ (DCIS) accounts for approximately 25% of new breast cancer diagnoses and carries a 20% to 50% risk of post-surgical upstaging to invasive cancer, complicating risk stratification and raising concerns about overtreat...
Papulopustular eruptions associated with EGFR-pathway-related targeted therapies: clinical spectrum, evidence boundaries, folliculocentric inflammation, and management considerations [0.03%]
与EGFR途径相关的靶向治疗相关的丘疹脓疱疹：临床表现，证据范围，毛囊为中心的炎症和管理考虑因素
Wei Li,Hui Xu
Wei Li
Papulopustular eruption is a characteristic dermatologic toxicity of classical epidermal growth factor receptor (EGFR) inhibitors and may impair quality of life, supportive-care needs, and treatment continuity. Although frequently termed ac...
Postoperative radiotherapy for resected esophageal squamous cell carcinoma: a systematic review and meta-analysis [0.03%]
手术切除食管鳞癌的术后放射治疗：系统评价和Meta分析
Ning Zhou,Peipei Zhao,Miaomiao Zhao et al.
Ning Zhou et al.
Background: The role of postoperative radiotherapy (PORT) in patients with radically resected esophageal squamous cell carcinoma (ESCC) remains controversial. This meta-analysis aimed to evaluate the efficacy of PORT comp...
Cancer outcomes and biological mechanisms among patients with type 2 diabetes mellitus using glucagon-like peptide-1 receptor agonists: a systematic review and meta-analysis [0.03%]
用于治疗2型糖尿病患者的胰高血糖素样肽-1受体激动剂对癌症预后和生物学机制的影响：系统评价和Meta分析
Ejike Daniel Eze,Leopold Ntakirutimana,Swase Dominic Terkimbi et al.
Ejike Daniel Eze et al.
Introduction: While glucagon-like peptide-1 receptor agonists (GLP-1RAs) provide metabolic and cardiovascular benefits in type 2 diabetes mellitus (T2DM) patients, uncertainty remains regarding their association with canc...
Metabolic cell competition in the glioblastoma tumour microenvironment: glucose, glutamine, and lactate as determinants of immune exclusion and targets for pharmacological reprogramming [0.03%]
胶质母细胞瘤肿瘤微环境中的代谢细胞竞争：葡萄糖、谷氨酰胺和乳酸作为免疫排除的决定因素及药理学重编目标
Egiroh Omene
Egiroh Omene
Glioblastoma (GBM) remains the most lethal primary brain tumour, with median overall survival of 14 to 16 months despite maximal safe surgical resection, concurrent chemoradiotherapy, and adjuvant temozolomide. Treatment failure is driven i...
Development and validation of a multimodality radiomics-based nomogram for predicting HER2 expression status in invasive breast cancer [0.03%]
一种用于预测侵袭性乳腺癌HER2表达状态的多模态影像组学列线图的开发与验证
Xianwei Yang,Xiaoling Liu,Shenghong Wan et al.
Xianwei Yang et al.
Background: This study aimed to develop and validate a nomogram integrating multimodal imaging and clinical features for the preoperative prediction of human epidermal growth factor receptor 2 (HER2) expression status in ...