Cyclooxygenases in pancreatic ductal adenocarcinoma: are they inflammatory catalysts for tumor growth [0.03%]
环氧化酶在胰腺导管腺癌中的作用：是否是肿瘤生长的炎症催化剂
Adile Orhan,Tugba Orhan,Hans Raskov et al.
Adile Orhan et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers with a relative 5-year survival around 12%. One of the greatest challenges in PDAC is the frequent systemic dissemination at the time of diagnosis and the dense,...
PKC isoforms in hematopoietic lineages and myeloid/lymphoid leukemias: mechanistic insights and therapeutic prospects [0.03%]
造血谱系和髓样/淋巴样白血病中的PKC异构体：机制见解与治疗前景
Xu Wang,Chunming Wang,Suling Li et al.
Xu Wang et al.
Leukemia remains a major clinical challenge due to high rates of drug resistance and recurrence, necessitating the identification of novel therapeutic targets. Protein kinase C (PKC) family, a central signaling hub regulating cell prolifera...
Clinical characteristics and management of renal solitary fibrous tumors: a narrative review with literature-derived case evidence [0.03%]
肾脏孤立性纤维瘤的临床特征和管理：带有文献病例证据的叙述性回顾
Liang Zhao,Jiang-Wei Man,Si-Yu Chen et al.
Liang Zhao et al.
Purpose: Renal solitary fibrous tumor is a rare mesenchymal neoplasm with heterogeneous biological behavior. This review summarizes current evidence regarding its epidemiology, diagnosis, treatment, and clinical outcomes ...
Impact of severe immunoparesis degree and duration on progression-free survival in newly diagnosed multiple myeloma: a retrospective cohort study of 258 patients [0.03%]
重度和持续时间不同的严重免疫瘫痪对多发性骨髓瘤患者无进展生存期的影响：258例新诊断患者的回顾性队列研究
Linlin Tian,Yuan Zhang,Jiong Chen et al.
Linlin Tian et al.
Objective: To investigate the relationship between the degree and duration of immunoparesis at diagnosis and poor prognosis in patients with newly diagnosed multiple myeloma (NDMM). ...
Tae Wook Nam,You Min Kim,Hye Mi Park et al.
Tae Wook Nam et al.
Introduction: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype characterized by limited targeted therapeutic options and frequent activation of the PI3K/AKT signaling pathway. EI24, a p53-respon...
Breast implant-associated anaplastic large cell lymphoma: a case report and literature review [0.03%]
与乳房植入物相关性大细胞淋巴瘤一例及文献复习
Shuangyi Qi,Hu Liu,Qidi Huang et al.
Shuangyi Qi et al.
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare T-cell non-Hodgkin lymphoma primarily associated with textured breast implants. Its pathological hallmarks include CD30 positivity, ALK negativity, and clonal T-c...
Mingjie Ding,Hao Li,Wenzhi Guo
Mingjie Ding
Warning of the poor effect of chemotherapy: primary gastric malignant melanoma misdiagnosed as "gastric adenocarcinoma": a case report and literature review [0.03%]
化疗疗效不佳警示:原发性胃恶性黑色素瘤误诊为"胃腺癌"1例及文献复习
Yuting Zhang,Ruzhu Wang,Tianshu Yang et al.
Yuting Zhang et al.
Primary gastric melanoma is a rare clinical finding. Its diagnosis can be challenging due to the complex tissue structure of the stomach and the diverse morphology of melanoma cells, which contribute to the increased likelihood of misdiagno...
Neoadjuvant versus perioperative immunotherapy in resectable NSCLC: A PD-L1-stratified Bayesian network meta-analysis [0.03%]
新辅助与围手术期免疫治疗在可切除NSCLC中的疗效：PD-L1分层的贝叶斯网状meta分析
Yi Jian,Zhijie Wu,Feihong Lai et al.
Yi Jian et al.
Background: Neoadjuvant immunochemotherapy (NIC) and perioperative immunochemotherapy (PIC) improve outcomes in resectable non-small cell lung cancer (NSCLC), but their relative effects across programmed death-ligand 1 (P...
Multimodal deep learning for prediction of postoperative recurrence in clear cell renal cell carcinoma: a clinical-radiologic-pathologic approach [0.03%]
基于临床-影像-病理的多模态深度学习预测透明细胞肾癌术后复发
Youchang Yang,Jiaojiao Wu,Feng Shi et al.
Youchang Yang et al.
Purpose: This study intends to develop and validate a multiclass system that efficiently integrates complementary information from patients' multimodal data (clinical, imaging, and pathological) to identify individuals at...