Advances in modeling gastric intestinal metaplasia: a comprehensive review of experimental models and mechanistic insights [0.03%]
胃肠道黏膜异位的实验模型及发病机制研究进展：全面综述
Xinyuan Liu,Kaiqi Yang,Nan Zhang et al.
Xinyuan Liu et al.
Epithelial cells within the gastric corpus mucosa exhibit a dynamic response to injury, characterized by alterations in gene transcription, cellular phenotype, and tissue organization, collectively termed metaplasia. Among these changes, ga...
Proposed observational study protocol for early differentiation of cytokine release syndrome and sepsis in CAR-T recipients with haematological malignancies using the IL-6/PCT ratio: the DRACARYS study [0.03%]
CAR-T细胞治疗血液系统恶性肿瘤后早期鉴别细胞因子释放综合征和脓毒症的观察性研究方案：基于IL-6/PCT比值的DRACARYS研究
Anas Ibraheem,Melanie Dalby
Anas Ibraheem
Chimeric Antigen Receptor T-cell (CAR-T) therapy has revolutionised treatment for haematological malignancies, demonstrating remarkable efficacy in B-cell leukaemias, lymphomas, and multiple myeloma. However, severe toxicities-particularly ...
Dosimetric parameter determination of a carbon-nanotube based miniature x-ray tube for HDR brachytherapy [0.03%]
基于碳纳米管的小型X射线管的HDR腔内治疗剂量学参数确定方法研究
Sang-Won Kang,Jin-Beom Chung,Keun-Yong Eom et al.
Sang-Won Kang et al.
Purpose: This study aims to determine key dosimetric parameters of a vacuum-sealed miniature X-ray tube (mXT) equipped with a carbon nanotube field emitter for application in HDR brachytherapy. ...
Prognostic factors for overall survival in patients with metastatic castration-resistant prostate cancer treated with radium-223: a meta-analysis of real-world evidence [0.03%]
用于接受镭-223治疗的转移性去势抵抗性前列腺癌患者的总生存期预后因素：真实世界证据的meta分析
Baolin Song,Huan Shao,Yanmei He et al.
Baolin Song et al.
Background: Metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease with limited treatment options. Radium-223 (Ra-223) improves survival in bone-predominant mCRPC, but real-world outcomes vary wi...
Rohith Battina,Raneen Rahhal,Anton Wellstein et al.
Rohith Battina et al.
The Hippo pathway is dysregulated in many cancers, leading to pro-oncogenic effects. The transcription factor TEAD plays a critical role in early development, tissue homeostasis, and cell proliferation, and it binds to the downstream Hippo ...
CMSP suppresses oral squamous cell carcinoma progression by targeting the JAK2/STAT3/c-Myc axis [0.03%]
CMSP通过靶向JAK2/STAT3/c-MYC轴抑制口腔鳞状细胞癌进展
Yueting Lu,Manman Yao,Dixian Wang et al.
Yueting Lu et al.
Background: Oral squamous cell carcinoma (OSCC) is a highly invasive head and neck malignancy with poor prognosis and limited treatment efficacy. This study aimed to investigate the anti-tumor potential of p-hydroxycinnam...
CldU sensitizes BRCA2 reverse-mutated cells to PARP inhibitors [0.03%]
细胞周期依赖性尿嘧啶掺入标记物CldU使BRCA2回突变细胞对PARP抑制剂敏感
Nawel Zouggari,Camilla Trugenberger,Valentine Du Bois et al.
Nawel Zouggari et al.
PARP inhibitors are widely used class of drugs for the treatment of homologous recombination deficient cancers, including BRCA mutated ones. These drugs led to substantial improvement in survival, particularly for patients with BRCA mutated...
Prognostic significance of the lymphocyte-to-high-density lipoprotein ratio in long-term efficacy of combined immunotherapy for advanced non-small cell lung cancer [0.03%]
淋巴细胞与高密度脂蛋白比率对晚期非小细胞肺癌联合免疫治疗长期疗效的预后价值分析
Gaolei Ma,Lijie Ma,Yuan Zhang et al.
Gaolei Ma et al.
Background: Lung cancer remains the leading cause of cancer incidence and mortality worldwide. Non-small cell lung cancer (NSCLC) accounts for approximately 80%-85% of cases, and the majority of patients are diagnosed at ...
Case Report: Should IGF-1R targeted therapy be revisited in Ewing sarcoma? a report of long-term complete response and review of the literature [0.03%]
个例报告：伊莫替尼联合放疗治疗尤因肉瘤获长期完全缓解——1例报告及文献复习
Georgios M Stergiopoulos,Brittany L Siontis,Safia K Ahmed et al.
Georgios M Stergiopoulos et al.
Introduction: Ewing sarcoma (ES) is a malignancy that mostly affects adolescents and young adults, with relapse or refractory cases posing major therapeutic challenges. Its unique transcriptional profile offers multiple t...
First-line immunochemotherapy for advanced NSCLC in Asian patients: a meta-analysis of phase 3 RCTs [0.03%]
亚洲晚期非小细胞肺癌一线免疫化疗的meta分析
Zhifang Mao,Zhiyong Zhang,Meijiao Song et al.
Zhifang Mao et al.
Background: PD-1/PD-L1 inhibitors plus chemotherapy (PC) are now broadly acknowledged as effective for treating stage IIIb-IV non-small cell lung cancer (NSCLC). However, data specific to Asian populations remain limited,...