Selinexor enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by regulating the BAX/Bcl-2/PUMA apoptotic pathway and the XPO1/p27 cell cycle pathway [0.03%]
Shenghong Du,Ling Wang,Chen Chen et al.
Shenghong Du et al.
Introduction: Sorafenib remains the first-line targeted therapy for advanced hepatocellular carcinoma (HCC), but its clinical efficacy is severely limited by intrinsic and acquired drug resistance. Dysregulation of the BA...
Transvaginal ultrasound-detected endometrial echogenicity heterogeneity in diagnosing endometrial carcinoma: risk factors and nomogram-based prediction model [0.03%]
Ling Yan,Jianxia Sun,Shengping Yang et al.
Ling Yan et al.
Objective: This study aimed to develop a nomogram prediction model based on risk factors associated with endometrial cancer (EC) diagnosed via transvaginal ultrasound (TVS)-detected non-uniform echogenicity. ...
Madelung's disease involving the scrotum: a case report and diagnostic pitfalls with liposarcoma [0.03%]
Shu-Hui Wang,Weiwei Yu
Shu-Hui Wang
Background: Madelung's disease is a rare metabolic disorder characterized by diffuse, symmetrical adipose tissue proliferation, strongly associated with chronic alcohol consumption. Scrotal involvement is exceedingly rare...
Case Report: TPR-ALK fusion-positive inflammatory myofibroblastic tumour treated with sequential ALK inhibitors [0.03%]
Fabiano Flauto,Filippo Vitale,Caterina De Luca et al.
Fabiano Flauto et al.
Background: Inflammatory myofibroblastic tumour (IMT) is a rare mesenchymal neoplasm, frequently driven by oncogenic kinase fusions, most commonly involving anaplastic lymphoma kinase (ALK). Standard cytotoxic therapies h...
Core needle biopsy as a first-line diagnostic tool for selected thyroid nodules: a real-world evaluation of diagnostic performance and safety [0.03%]
Xing Li,Yi Pan,Yanmei Ou et al.
Xing Li et al.
Purpose: This study aimed to evaluate the diagnostic performance and safety of core needle biopsy (CNB) as a first-line diagnostic tool for selected thyroid nodules with suspicious imaging features or other high-risk char...
Predictive value of the systemic immune-inflammation index combined with the prognostic nutritional index for postoperative recurrence in early-stage cervical cancer: evidence from a multicenter cohort study [0.03%]
Anihenimu Abudoukade,Shihao Hong,Min Jiang et al.
Anihenimu Abudoukade et al.
Background: Growing evidence suggests that immune-inflammatory status and nutritional condition influence cancer prognosis. In this study, a composite score combining the systemic immune ~ inflammation index (SII) and the...
Perspective recommendations on geriatric support for older adults with multiple myeloma based on challenges faced by a multidisciplinary team [0.03%]
Julie Côté,Ploa Desforges,Christine Dionne et al.
Julie Côté et al.
Background: Multiple Myeloma (MM) predominantly affects older adults, with a median diagnosis age of 70 years, posing challenges in management due to frailty, comorbidities, and age-related physiological changes. As the a...
Case Report: Successful natural conception and delivery in a primary cancer survivor involving the reproductive, respiratory, and endocrine systems auth [0.03%]
Limei Tao,Shaojia Wang,Li Zhuan et al.
Limei Tao et al.
Background: Natural conception in patients with multiple primary neoplasms (MPNs) is exceedingly rare, particularly those involving metachronous triple cancers of the reproductive, respiratory, and endocrine systems. This...
Association between baseline hemoglobin levels and pathological complete response in 404 female breast cancer patients undergoing neoadjuvant therapy in Western Guangdong region: a retrospective cohort study [0.03%]
Lixia Li,Jiacheng Yang,Huijie Deng et al.
Lixia Li et al.
Background: Breast cancer is the most common female malignancy globally and a leading cause of cancer-related death. In China, an estimated 350,000 new cases were reported in 2022, with more than 65% of patients aged ≤35...
Development of a post-treatment prognostic model for hepatocellular carcinoma based on nutritional, immune, and inflammatory scoring systems and REDCap-enabled follow-up [0.03%]
Xuemei Liu,Chunxiao Wei,Maoyu Jiang et al.
Xuemei Liu et al.
Background: This study examined the association between pre-treatment inflammation, immune cell- and nutrition/metabolism-related scores, and prognosis of patients with hepatocellular carcinoma (HCC) post-treatment. ...