Design, evaluation and in vitro - in vivo correlation of glibenclamide buccoadhesive films [0.03%]
设计、评价及评估グリベンクラミド颊黏附膜的体外-体内相关性
R Indira Prasanna,K Uma Sankari
R Indira Prasanna
Background: Glibenclamide (G) is a popular anti-diabetic drug, belonging to the class of sulfonylurea. The drug is widely used for treating type II diabetes but it undergoes first-pass effect. A novel aspiration in treatm...
The effect of water on the solid state characteristics of pharmaceutical excipients: Molecular mechanisms, measurement techniques, and quality aspects of final dosage form [0.03%]
水对药用辅料固态特性影响的分子机制、测量技术和制剂终产品质量属性方面的影响
Gergely Szakonyi,Romána Zelkó
Gergely Szakonyi
In this paper we give an overview about the interaction of water molecules with pharmaceutical excipients. Most of these excipients are amorphous or partially amorphous polymers and their characteristics are very sensitive to the water cont...
Improvement in solubility of poor water-soluble drugs by solid dispersion [0.03%]
固体分散体改善难溶性药物溶解度研究进展
Swati Sareen,George Mathew,Lincy Joseph
Swati Sareen
This article is intended to combine recent literature on solid dispersion technology for solubility enhancement with special emphasis on mechanism responsible for the same by solid dispersion, various preparation methods, and evaluation par...
Gaurav Tiwari,Ruchi Tiwari,Birendra Sriwastawa et al.
Gaurav Tiwari et al.
Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing ...
Barkat Ali Khan
Barkat Ali Khan
Formulation and evaluation of mixed matrix gastro-retentive drug delivery for famotidine [0.03%]
雷尼替丁混杂基质胃滞留释药系统的设计与评价
Dasharath M Patel,Mehul J Patel,Ankit N Patel et al.
Dasharath M Patel et al.
Introduction: Present investigation describes an influence of ratio of Gelucire 43/01(hydrophobic) to hydroxypropyl methylcellulose K4M (HPMC K4M) (hydrophilic) and different fillers on release of famotidine from gastro-r...
Formulation development and investigation of domperidone transdermal patches [0.03%]
多潘立酮透皮贴剂的制剂开发及研究
Prabhakar Prabhu,Samip Shah,Shankar Gundad
Prabhakar Prabhu
Aim and background: Domperidone is a dopamine antagonist with antiemetic properties having a plasma half life of 7-9 h with 15% oral bioavailability. In the present work transdermal patches of domperidone were prepared wi...
Biophysical assessment of DC iontophoresis and current density on transdermal permeation of methotrexate [0.03%]
直流电离子导入及电流密度对甲氨蝶呤经皮渗透的生物物理评估
Rachna Prasad,Sneh Anand,Veena Koul
Rachna Prasad
Introduction: The effect of DC iontophoresis using low (0.2 mA/cm(2)) and high current density (0.5 mA/cm(2)) on transdermal permeation of methotrexate loaded into polyacrylamide hydrogel patch was investigated. ...
Development and characterization of chronomodulated drug delivery system of captopril [0.03%]
卡托普利释药系统的开发及表征研究
Archana S Patil,Panchaxari M Dandagi,Vinayak S Masthiholimath et al.
Archana S Patil et al.
Background: Hypertension shows circadian rhythm that there is a rise in pressure from the time of waking or before (about 4 to 8 a.m.), in most people. Conventional drug delivery system of captopril is inappropriate for t...
Santosh S Bhujbal,Sunita S Hadawale,Parag A Kulkarni et al.
Santosh S Bhujbal et al.
Background and aim: Momordica charantia Linn. is traditionally used as a medicine for diabetes. The present investigation was aimed to formulate and evaluate transdermal patchesof Momordica charantia Linn. ...