The gramine route to pyrido[4,3-b]indol-3-ones - identification of a new cytotoxic lead [0.03%]
新的细胞毒性先导化合物——吡啶并[4,3-b]吲哚-3-酮的合成路线
Uwe Wollein,Franz Bracher
Uwe Wollein
A novel approach to 3-oxo-γ-carbolines was worked out starting from methyl indol-2-ylacetate via a gramine derivative. After quaternization, ammonia and 4-methoxybenzylamine could be inserted giving appropriate 3-oxo-γ-carbolines. Condens...
Chemometric QSAR modeling and in silico design of antioxidant NO donor phenols [0.03%]
抗氧化NO供体酚的化学计量QSAR建模及计算机辅助设计研究
Indrani Mitra,Achintya Saha,Kunal Roy
Indrani Mitra
An acceleration of free radical formation within human system exacerbates the incidence of several life-threatening diseases. The systemic antioxidants often fall short for neutralizing the free radicals thereby demanding external antioxida...
New substituted isocoumarins and Dihydroisocoumarins and their cytotoxic activities [0.03%]
具有细胞毒活性的取代异香豆素和二氢异香豆素类化合物
Veronika Hampl,Isolde Wetzel,Franz Bracher et al.
Veronika Hampl et al.
New isocoumarins were prepared in an efficient way from 2-iodobenzoic acid derivatives and hept-1-yne in a Sonogashira reaction, followed by spontaneous cyclization. Catalytic hydrogenation gave the corresponding dihydroisocoumarins. A 4-ch...
Phytoestrogen biological actions on Mammalian reproductive system and cancer growth [0.03%]
植物雌激素对哺乳动物生殖系统和癌症生长的生物作用
E Zhao,Qing Mu
E Zhao
Phytoestrogens are a family of diverse polyphenolic compounds derived from nature plant that structurally or functionally mimic circulating estrogen in the mammalian reproductive system. They induce estrogenic and anti-estrogenic effects in...
Retraction [0.03%]
撤稿通知
Retraction of Publication
Scientia pharmaceutica. 2010 Jan-Mar;78(1):118. DOI:10.3797/scipharm.ed-10-02 2010
In vivo bioavailability and therapeutic assessment of host-guest inclusion phenomena for the hydrophobic molecule etodolac: pharmacodynamic and pharmacokinetic evaluation [0.03%]
药代动力学及药效学评估羟喜树碱主客体包合作用的体内生物利用度及疗效研究
Vivek Ranjan Sinha,Amita,Honey Goel
Vivek Ranjan Sinha
The aim of present investigation was 1) to evaluate the in vivo bioavailability of an Etodolac (ETD)-Î-cyclodextrin (Î-CD) inclusion complex system prepared by kneading and spray drying techniques in rats, 2) to study the pharmacodynamic ...
Antiproliferative activity of plant extracts used against cancer in traditional medicine [0.03%]
传统医药中用于癌症治疗的植物提取物的抗增殖活性
Wamidh H Talib,Adel M Mahasneh
Wamidh H Talib
Forty four extracts from sixteen plants used traditionally as anticancer agents were evaluated in vitro for their antiproliferative activity against Hep-2, MCF-7, and Vero cell lines. Plants were fractionated using ethanol, methanol, chloro...
Release kinetic studies of aspirin microcapsules from ethyl cellulose, cellulose acetate phthalate and their mixtures by emulsion solvent evaporation method [0.03%]
以乙基纤维素、邻苯二甲酸纤维素及它们的混合物为壁材制备阿司匹林微胶囊的体外释放规律研究
Vikas Dash,Sujeet K Mishra,Manoj Singh et al.
Vikas Dash et al.
The present study was oriented towards microencapsulation of aspirin and the study of its release kinetics. The desired encapsulation was achieved by emulsion solvent evaporation method using ethyl cellulose (EC), cellulose acetate phthalat...
Evaluation of ketorolac tromethamine microspheres by chitosan/gelatin B complex coacervation [0.03%]
壳聚糖/明胶B复合凝聚体系评价酮咯酸缓释微球
Sanat Kumar Basu,Kunchu Kavitha,Mani Rupeshkumar
Sanat Kumar Basu
Microspheres (MS) of Ketorolac Tromethamine (KT) for oral delivery were prepared by complex coacervation (method-1) and simple coacervation (method-2) methods without the use of chemical crossâlinking agent (glutaraldehyde) to avoid the to...
Chitosan-carboxymethyl tamarind kernel powder interpolymer complexation: investigations for colon drug delivery [0.03%]
壳聚糖-羧甲基塔纳/kernel粉末 interpolymers 复杂的调查：药物输送 colon drug delivery
Gurpreet Kaur,Subheet Jain,Ashok K Tiwary
Gurpreet Kaur
The present study was aimed at evaluating the possible use of inter polymer complexed (IPC) films of chitosan (CH) and carboxymethyl tamarind kernel powder (CMTKP) for colon release of budesonide. Viscosity analysis of the supernatant liqui...