Xiaoming Ouyang,Yu Liu,Yang Zhou et al.
Xiaoming Ouyang et al.
Induced pluripotent stem cells (iPSCs) and cancer cells share cellular similarities and transcriptomic profiles. Here, we show that an iPSC-based cancer vaccine, comprised of autologous iPSCs and CpG, stimulated cytotoxic antitumor CD8+ T c...
Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the epidermal growth factor receptor [0.03%]
神经胶质细胞调节果蝇肠干细胞通过表皮生长因子受体的信号转导增强肠道干细胞增殖
Martin Resnik-Docampo,Kathleen M Cunningham,S Mateo Ruvalcaba et al.
Martin Resnik-Docampo et al.
The Drosophila intestine is an excellent system for elucidating mechanisms regulating stem cell behavior. Here we show that the septate junction (SJ) protein Neuroglian (Nrg) is expressed in intestinal stem cells (ISCs) and enteroblasts (EB...
A regulatory role for CHD4 in maintenance of the spermatogonial stem cell pool [0.03%]
CHD4在维持精原干细胞池中的调控作用
Shenae L Cafe,David A Skerrett-Byrne,Camila Salum De Oliveira et al.
Shenae L Cafe et al.
Maintenance and self-renewal of the spermatogonial stem cell (SSC) population is the cornerstone of male fertility. Here, we have identified a key role for the nucleosome remodeling protein CHD4 in regulating SSC function. Gene expression a...
The chromatin accessibility landscape reveals distinct transcriptional regulation in the induction of human primordial germ cell-like cells from pluripotent stem cells [0.03%]
染色质可及性景观揭示了从多能干细胞诱导人原始生殖细胞样细胞中的不同转录调控
Xiaoman Wang,Veeramohan Veerapandian,Xinyan Yang et al.
Xiaoman Wang et al.
In vitro induction of human primordial germ cell-like cells (hPGCLCs) provides an ideal platform to recapitulate hPGC development. However, the detailed molecular mechanisms regulating the induction of hPGCLCs remain largely uncharacterized...
Automatic identification of small molecules that promote cell conversion and reprogramming [0.03%]
自动识别促进细胞转化和重编程的小分子
Francesco Napolitano,Trisevgeni Rapakoulia,Patrizia Annunziata et al.
Francesco Napolitano et al.
Controlling cell fate has great potential for regenerative medicine, drug discovery, and basic research. Although transcription factors are able to promote cell reprogramming and transdifferentiation, methods based on their upregulation oft...
Gastruloids generated without exogenous Wnt activation develop anterior neural tissues [0.03%]
无外源Wnt激活的起始细胞可生成具有前脑神经组织的类胚胎体
Mehmet U Girgin,Nicolas Broguiere,Lorenzo Mattolini et al.
Mehmet U Girgin et al.
When stimulated with a pulse from an exogenous WNT pathway activator, small aggregates of mouse embryonic stem cells (ESCs) can undergo embryo-like axial morphogenesis and patterning along the three major body axes. However, these structure...
The role of SQSTM1 (p62) in mitochondrial function and clearance in human cortical neurons [0.03%]
SQSTM1(p62)在人类皮层神经元的线粒体功能和清除中的作用
Anna Poon,Harpreet Saini,Siddharth Sethi et al.
Anna Poon et al.
Sequestosome-1 (SQSTM1/p62) is involved in cellular processes such as autophagy and metabolic reprogramming. Mutations resulting in the loss of function of SQSTM1 lead to neurodegenerative diseases including frontotemporal dementia. The pat...
Gene expression dynamics underlying cell fate emergence in 2D micropatterned human embryonic stem cell gastruloids [0.03%]
基于二维微图案的人类胚胎干细胞原肠胚基因表达动力学及其细胞命运偏向性研究
Kyaw Thu Minn,Sabine Dietmann,Sarah E Waye et al.
Kyaw Thu Minn et al.
Human embryonic stem cells cultured in 2D micropatterns with BMP4 differentiate into a radial arrangement of germ layers and extraembryonic cells. Single-cell transcriptomes demonstrate generation of cell types transcriptionally similar to ...
Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition [0.03%]
FUS突变引起的运动神经元功能障碍及HDAC6抑制改善作用的微流控装置研究
Katarina Stoklund Dittlau,Emily N Krasnow,Laura Fumagalli et al.
Katarina Stoklund Dittlau et al.
Neuromuscular junctions (NMJs) ensure communication between motor neurons (MNs) and muscle; however, in MN disorders, such as amyotrophic lateral sclerosis (ALS), NMJs degenerate resulting in muscle atrophy. The aim of this study was to est...
Non-muscle myosin heavy chain 9 maintains intestinal homeostasis by preventing epithelium necroptosis and colitis adenoma formation [0.03%]
非肌球蛋白重链9通过防止上皮细胞坏死性凋亡和肠道腺瘤形成来维持肠稳态
Shan Wang,Siqi Li,Yehua Li et al.
Shan Wang et al.
Non-muscle myosin IIA plays an important role in cell adhesion, cell migration, and tissue architecture. We previously showed that low activity of the heavy chain of non-muscle myosin II Myh9 is beneficial to LGR5+ intestinal stem cell main...