Trophoblast stem cell derivation from naive and primed hPSC enables ELF5 functional analysis [0.03%]
Naive和primed人多能干细胞向滋养细胞干细胞分化及ELF5的功能分析
Joonas Sokka,Ella Lapinsuo,Jouni Kvist et al.
Joonas Sokka et al.
Human pluripotent stem cells (hPSCs) are valuable tools for studying placental biology, yet their differentiation into bona fide trophoblast stem cells (TSCs) remains challenging. In this study, we established and thoroughly compared naive ...
Unraveling the matrisome signatures of quiescent and activated muscle stem cells [0.03%]
静止和活化的肌肉干细胞的基质组分谱型解析
Emilie Guillon,Hisoilat Bacar,Laurent Gilquin et al.
Emilie Guillon et al.
The extracellular matrix (ECM) forms a dynamic microenvironment, known as the "niche," that influences muscle stem cell (MuSC) behavior. Its composition and topology remain underexplored. Using bioinformatics analysis of publicly available ...
Ectopic recruitment of neuroblasts in striatal myelin bundles and nucleus accumbens following AraC chemical lesion [0.03%]
AraC化学损伤后壳神经髓鞘束和纹状体核中神经干细胞的异位招募
Irini Thanou,Paraskevi N Koutsoudaki,Maria Margariti et al.
Irini Thanou et al.
In the adult brain, neural stem cells (NSCs) constitutively generate new neurons in specific neurogenic domains. Recent research has unveiled reactive neurogenesis, whereby brain injury triggers NSC activation, enhancing their differentiati...
Engineering human neuronal diversity: Morphogens and stem cell technologies for neurodevelopmental biology [0.03%]
工程化人类神经元多样性：形态发生素和干细胞技术在神经系统发育生物学中的应用
Soraya Scuderi,Nagham Khouri-Farah,Riya Rauthan et al.
Soraya Scuderi et al.
A complex assortment of neuronal cells contributes to distinct functional circuits in the human brain. Such diversity is imposed upon pluripotent stem cells by a patterning process that begins much before the start of neurogenesis. Neural t...
Sara Mancinelli,Sebastiano Bariselli,Simona Lodato
Sara Mancinelli
Human brain organoids, generated from pluripotent stem cells, recapitulate fundamental features of human brain development, including neuronal diversity, regional architecture, and functional network activity. Integrated multimodal and tran...
Megumi Mizoguchi,Sebastian Jessberger,Yusaku Hontani
Megumi Mizoguchi
The lifelong addition of stem-cell-derived neurons into distinct areas of the mammalian brain, such as the olfactory bulb and hippocampal dentate gyrus, provides structural and functional plasticity to neural circuits. To understand the dyn...
Perturbing neural stem cell fate in glioblastoma heterogeneity and beyond [0.03%]
胶质母细胞瘤异质性及其他领域的神经干细胞命运扰动
Ethan W Hollingsworth,Jaime Imitola
Ethan W Hollingsworth
Intratumoral heterogeneity in glioblastoma is thought to underlie its remarkable ability to recur and resist therapies. Its origins, however, remain unknown. In this issue, Liu et al. model the contributions of cell-of-origin and genetic dr...
Distinct roles of TET-mediated cytosine oxidation in neural stem cell fate decisions [0.03%]
TET介导的胞嘧啶氧化在神经干细胞命运决定中的不同作用
Oren Ram
Oren Ram
Ten-eleven translocation (TET) enzymes regulate neural stem cell development via distinct cytosine oxidation steps. This study, by Ebert et al. reveals that hydroxymethylation is crucial for neurogenesis, while formylation and carboxylation...
Fiona Doetsch,Rebecca Matsas
Fiona Doetsch
The KAP1 chromatin regulator and Paupar long non-coding RNA control subventricular zone neural stem cell maintenance and neurogenesis [0.03%]
KAP1染色质调节因子和Paupar长非编码RNA控制侧脑室下区神经干细胞的维持及神经发生
Farah Alammari,Jemima Becker,Bin Sun et al.
Farah Alammari et al.
Neural stem cells (NSCs) in the subventricular zone (SVZ) produce neurons throughout life. However, the epigenetic mechanisms that maintain NSCs and control neurogenesis remain unclear. We previously showed the long non-coding RNA (lncRNA) ...