Genetic Engineering of Human Embryonic Stem Cells for Precise Cell Fate Tracing during Human Lineage Development [0.03%]
基因工程化的人类胚胎干细胞在人类谱系发育过程中用于精确细胞命运追踪
Zhenyu Chen,Xudong Ren,Xiangjie Xu et al.
Zhenyu Chen et al.
Published Erratum
Stem cell reports. 2026 Jul 30:103054. DOI:10.1016/j.stemcr.2026.103054 2026
Targeted Differentiation of Regional Ventral Neuroprogenitors and Related Neuronal Subtypes from Human Pluripotent Stem Cells [0.03%]
人多能干细胞向区域 ventral 神经前体细胞及其神经亚型分化的定向分化
Liankai Chi,Beibei Fan,Kunshan Zhang et al.
Liankai Chi et al.
Published Erratum
Stem cell reports. 2026 Jul 30:103055. DOI:10.1016/j.stemcr.2026.103055 2026
Brain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replication [0.03%]
大脑皮层发生促进SARS-CoV-2通过脂依赖性病毒复制产生神经胶细胞亲嗜性
Byoung-San Moon,Dae-Gyun Ahn,Jieun Park et al.
Byoung-San Moon et al.
While extensive research has examined the neuroinvasiveness of SARS-CoV-2, its relationship with brain maturation remains unclear. Using a multi-omics approach, we established cerebral organoid (CBO) at day 60 (EB60) and day 120 (EB120) to ...
Allogeneic iPSC-derived γδT cells demonstrate antitumor efficacy against patient-derived tissues [0.03%]
同种异体诱导多能干细胞衍生的γδT细胞对患者来源组织具有抗肿瘤功效
Ryoko Futai,Michiyo Koyanagi-Aoi,Aito Nakahashi et al.
Ryoko Futai et al.
Various immunotherapies have been developed to treat malignant tumors, and autologous CAR-T cell therapy is clinically used for certain malignancies. However, their efficacy against solid tumors is limited. γδT cells are recognized for th...
High and intermittent hydrostatic pressure promotes maturation of engineered cardiac tissues derived from human pluripotent stem cells [0.03%]
高压间歇水静压促进人多能干细胞源性工程心脏组织成熟化
Wusiman Maihemuti,Kozue Murata,Takahiro Jimba et al.
Wusiman Maihemuti et al.
The immaturity of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) and engineered cardiac tissues (ECTs) limits their use in regenerative therapies. Ventricular loading pressure plays a vital role in cardiac repair, prompting t...
Unproven stem cell-based interventions marketed as treatments in Panama: An urgent call for enforcement actions [0.03%]
巴拿马市场上打着治疗旗号的干细胞干预措施亟待规范执法——基于事实的分析报告
Mairim Alexandra Solis,Magalys Quintana,Jesica E Candanedo P et al.
Mairim Alexandra Solis et al.
The marketing of unproven stem cell-based interventions raises public health, ethical, and regulatory challenges. This article examines online marketing in Panama, identifies new businesses, and argues that lack of enforcement has contribut...
The imprinted Peg3 gene is a potent regulator of the DNA methylome in trophoblast cells [0.03%]
Peg3基因通过表观遗传重编程在滋养细胞层中发挥重要作用
Caroline Kokorudz,Noura Ballasy,Bethany N Radford et al.
Caroline Kokorudz et al.
Paternally expressed gene 3 (Peg3) is an imprinted gene whose knockout (KO) causes placental and fetal growth deficits as well as maternal behavioral defects, but its molecular role remains poorly understood. Here, we report that Peg3-null ...
Single cell CRISPR screen identifies antagonism between Nsd1-H3K36me2 and Ezh2-H3K27me3 orchestrates pluripotency transition [0.03%]
单细胞CRISPR筛选鉴定出Nsd1-H3K36me2与Ezh2-H3K27me3的拮抗作用调控多能性转换
Yuqing Zhu,Qingying Wang,Yanzi Cao et al.
Yuqing Zhu et al.
The transcriptional and epigenetic landscape imposes constraints on the self-renewal capacity and lineage specification potential of both naive and primed mouse embryonic stem cells (mESCs). CRISPR/Cas9-based functional screening coupled wi...
CCL5 exposure promotes acute and transient megakaryopoiesis and hematopoietic progenitor expansion [0.03%]
暴露于CCL5促进急性而短暂的巨核系谱细胞生成和造血祖细胞增殖
Maria N Barrachina,Dong H Lee,Virginia Camacho et al.
Maria N Barrachina et al.
During inflammation, megakaryocytes (MKs) can expand from hematopoietic stem cells, yet the specific driving factors remain unclear. We investigated whether C-C Motif Chemokine Ligand 5 (CCL5) influences this process in murine and human iPS...
Brain injury reactivates a developmental program driving genesis and integration of transient LGE-class interneurons [0.03%]
脑损伤重新激活了一个发育程序，驱动LGE类中间神经元的生成和整合
G Nato,M Fogli,N Marichal et al.
G Nato et al.
Brain lesions can unlock latent neurogenic potential in parenchymal astrocytes, but the identity of their neuronal progeny has remained unclear. Here, we show that neurons generated by striatal astrocytes after excitotoxic lesions are trans...