Expression dynamics of HAND1/2 in in vitro human cardiomyocyte differentiation [0.03%]
HAND1/2在体外人诱导多能干细胞分化的心肌细胞中的表达动态研究
Chikako Okubo,Megumi Narita,Azusa Inagaki et al.
Chikako Okubo et al.
Hand1 and Hand2 are transcriptional factors, and knockout mice of these genes show left and right ventricular hypoplasia, respectively. However, their function and expression in human cardiogenesis are not well studied. To delineate their e...
Hypersensitivity response has negligible impact on Hematopoietic Stem Cells [0.03%]
超敏反应对造血干细胞影响可以忽略不计
Nir Bujanover,Roshina Thapa,Oron Goldstein et al.
Nir Bujanover et al.
Immune cells are generated from hematopoietic stem cells (HSCs) in the bone marrow (BM). Immune stimulation can rapidly activate HSCs out of their quiescent state to accelerate the generation of immune cells. HSCs' activation follows variou...
Fractalkine signaling regulates oligodendroglial cell genesis from SVZ precursor cells [0.03%]
趋化因子fractalkine调节SVZ前体细胞向少突胶质细胞分化生成的功能及机制研究
Adrianne E S Watson,Monique M A de Almeida,Nicole L Dittmann et al.
Adrianne E S Watson et al.
Neural and oligodendrocyte precursor cells (NPCs and OPCs) in the subventricular zone (SVZ) of the brain contribute to oligodendrogenesis throughout life, in part due to direct regulation by chemokines. The role of the chemokine fractalkine...
Extraordinary challenge, extraordinary achievement: 2020-2021 year in review [0.03%]
不凡之挑战，不凡之业绩——2020至2021年度总结报告
Christine Mummery
Christine Mummery
Published Erratum
Stem cell reports. 2021 Jul 13;16(7):1845. DOI:10.1016/j.stemcr.2021.06.012 2021
Dysregulated ECM remodeling proteins lead to aberrant osteogenesis of Costello syndrome iPSCs [0.03%]
调控异常的ECM重塑蛋白导致Costello综合征iPSCs成骨分化异常
Jong Bin Choi,Joonsun Lee,Minyong Kang et al.
Jong Bin Choi et al.
Costello syndrome (CS) is an autosomal dominant disorder caused by mutations in HRAS. Although CS patients have skeletal abnormalities, the role of mutated HRAS in bone development remains unclear. Here, we use CS induced pluripotent stem c...
The histone H3.3 chaperone HIRA restrains erythroid-biased differentiation of adult hematopoietic stem cells [0.03%]
组蛋白H3.3伴侣HIRA限制成年造血干细胞向红细胞偏倚分化
Rebecca L Murdaugh,Kevin A Hoegenauer,Ayumi Kitano et al.
Rebecca L Murdaugh et al.
Histone variants contribute to the complexity of the chromatin landscape and play an integral role in defining DNA domains and regulating gene expression. The histone H3 variant H3.3 is incorporated into genic elements independent of DNA re...
Improved hematopoietic stem cell transplantation upon inhibition of natural killer cell-derived interferon-gamma [0.03%]
干扰素-γ衍生NK细胞抑制改善造血干细胞移植
Lorena Lobo de Figueiredo-Pontes,Miroslava K Adamcova,Srdjan Grusanovic et al.
Lorena Lobo de Figueiredo-Pontes et al.
Hematopoietic stem cell transplantation (HSCT) is a frequent therapeutic approach to restore hematopoiesis in patients with hematologic diseases. Patients receive a hematopoietic stem cell (HSC)-enriched donor cell infusion also containing ...
Generation of caudal-type serotonin neurons and hindbrain-fate organoids from hPSCs [0.03%]
人多能干细胞生成尾侧5-羟色胺神经元和hindbrain命运类器官
Parvin Valiulahi,Vincencius Vidyawan,Lesly Puspita et al.
Parvin Valiulahi et al.
Serotonin (5-HT) neurons, the major components of the raphe nuclei, arise from ventral hindbrain progenitors. Based on anatomical location and axonal projection, 5-HT neurons are coarsely divided into rostral and caudal groups. Here, we pro...
Synaptic repair and vision restoration in advanced degenerating eyes by transplantation of retinal progenitor cells [0.03%]
视网膜神经节细胞移植修复晚期病变眼睛的视觉通路及恢复视力
Xiang-Yu He,Cong-Jian Zhao,Haiwei Xu et al.
Xiang-Yu He et al.
Stem cell transplantation shows enormous potential for treatment of incurable retinal degeneration (RD). To determine if and how grafts connect with the neural circuits of the advanced degenerative retina (ADR) and improve vision, we perfor...
Recognizing the ethical implications of stem cell research: A call for broadening the scope [0.03%]
论干细胞研究的伦理含义：扩大视野的呼吁
Lars S Assen,Karin R Jongsma,Rosario Isasi et al.
Lars S Assen et al.
The ethical implications of stem cell research are often described in terms of risks, side effects, safety, and therapeutic value, which are examples of so-called hard impacts. Hard impacts are typically measurable and quantifiable. To unde...