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Generation of caudal-type serotonin neurons and hindbrain-fate organoids from hPSCs

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Serotonin (5-HT) neurons, the major components of the raphe nuclei, arise from ventral hindbrain progenitors. Based on anatomical location and axonal projection, 5-HT neurons are coarsely divided into rostral and caudal groups. Here, we propose a novel strateg... ...