Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes [0.03%]
人源心肌细胞移植引起的植入性心律失常的药理学治疗
Kenta Nakamura,Lauren E Neidig,Xiulan Yang et al.
Kenta Nakamura et al.
Heart failure remains a significant cause of morbidity and mortality following myocardial infarction. Cardiac remuscularization with transplantation of human pluripotent stem cell-derived cardiomyocytes is a promising preclinical therapy to...
Defining the nature of human pluripotent stem cell-derived interneurons via single-cell analysis [0.03%]
单细胞分析定义人多能干细胞来源的中间神经元的性质
Thomas Allison,Justin Langerman,Shan Sabri et al.
Thomas Allison et al.
The specification of inhibitory neurons has been described for the mouse and human brain, and many studies have shown that pluripotent stem cells (PSCs) can be used to create interneurons in vitro. It is unclear whether in vitro methods to ...
The aryl hydrocarbon receptor promotes differentiation during mouse preimplantational embryo development [0.03%]
aryl烃受体在小鼠着床前胚胎发育中促进分化作用
Ana Nacarino-Palma,Francisco J González-Rico,Claudia M Rejano-Gordillo et al.
Ana Nacarino-Palma et al.
Mammalian embryogenesis is a complex process controlled by transcription factors that regulate the balance between pluripotency and differentiation. Transcription factor aryl hydrocarbon receptor (AhR) regulates OCT4/POU5F1 and NANOG, both ...
Engineered 3D vessel-on-chip using hiPSC-derived endothelial- and vascular smooth muscle cells [0.03%]
基于hiPSC来源的血管内皮细胞及血管平滑肌细胞的三维微组织芯片技术
Marc Vila Cuenca,Amy Cochrane,Francijna E van den Hil et al.
Marc Vila Cuenca et al.
Crosstalk between endothelial cells (ECs) and pericytes or vascular smooth muscle cells (VSMCs) is essential for the proper functioning of blood vessels. This balance is disrupted in several vascular diseases but there are few experimental ...
NOTCH-mediated ex vivo expansion of human hematopoietic stem and progenitor cells by culture under hypoxia [0.03%]
缺氧培养介导的NOTCH信号使人类造血干细胞和祖细胞体外扩增
Daisuke Araki,Jian Fei Fu,Heather Huntsman et al.
Daisuke Araki et al.
Activation of NOTCH signaling in human hematopoietic stem/progenitor cells (HSPCs) by treatment with an engineered Delta-like ligand (DELTA1ext-IgG [DXI]) has enabled ex vivo expansion of short-term HSPCs, but the effect on long-term repopu...
POLYseq: A poly(β-amino ester)-based vector for multifunctional cellular barcoding [0.03%]
基于聚（β-氨基酯）的用于多功能细胞条形码技术的载体 POLYseq
Andrew Dunn,Yuqi Cai,Kentaro Iwasawa et al.
Andrew Dunn et al.
Despite evolving biological application of next-generation sequencing (NGS) at single-cell level, current techniques in NGS library preparation restrict multiplexing, necessitating the costly preparation of distinct libraries for each sampl...
The tumor suppressor WT1 drives progenitor cell progression and epithelialization to prevent Wilms tumorigenesis in human kidney organoids [0.03%]
肿瘤抑制因子WT1驱动谱系前体细胞进程和上皮化以防止维尔姆斯瘤在人类肾脏类器官中的发生
Verena Waehle,Rosemarie Ungricht,Philipp S Hoppe et al.
Verena Waehle et al.
Wilms tumor is the most widespread kidney cancer in children and frequently associated with homozygous loss of the tumor suppressor WT1. Pediatric tumorigenesis is largely inaccessible in humans. Here, we develop a human kidney organoid mod...
CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration [0.03%]
肌肉再生过程中CHD4确保干细胞系的特异性
Krishnamoorthy Sreenivasan,Alejandra Rodríguez-delaRosa,Johnny Kim et al.
Krishnamoorthy Sreenivasan et al.
Regeneration of skeletal muscle requires resident stem cells called satellite cells. Here, we report that the chromatin remodeler CHD4, a member of the nucleosome remodeling and deacetylase (NuRD) repressive complex, is essential for the ex...
Generation of pancreatic progenitors from human pluripotent stem cells by small molecules [0.03%]
小分子诱导人多能干细胞向胰腺谱系定向分化
Yuqian Jiang,Chuanxin Chen,Lauren N Randolph et al.
Yuqian Jiang et al.
Human pluripotent stem cell (hPSC)-derived pancreatic progenitors (PPs) provide promising cell therapies for type 1 diabetes. Current PP differentiation requires a high amount of Activin A during the definitive endoderm (DE) stage, making i...
Modeling HNF1B-associated monogenic diabetes using human iPSCs reveals an early stage impairment of the pancreatic developmental program [0.03%]
利用人类诱导多能干细胞模拟HNF1B单基因糖尿病揭示胰腺发育程序早期阶段的损伤
Ranna El-Khairi,Evelyn Olszanowski,Daniele Muraro et al.
Ranna El-Khairi et al.
Heterozygous mutations in HNF1B in humans result in a multisystem disorder, including pancreatic hypoplasia and diabetes mellitus. Here we used a well-controlled human induced pluripotent stem cell pancreatic differentiation model to elucid...