FGFR3 is expressed by human primordial germ cells and is repressed after meiotic initiation to form primordial oocytes [0.03%]
FGFR3由人类原始生殖细胞表达，在形成原始卵胞母细胞时减数分裂开始后受到抑制
Tsotne Chitiashvili,Fei-Man Hsu,Iris Dror et al.
Tsotne Chitiashvili et al.
Human germ cell development is a highly regulated process beginning soon after embryo implantation with the specification of primordial germ cells (PGCs) and ending in adulthood with the differentiation of gametes. Here, we show that fibrob...
Esrrb is a cell-cycle-dependent associated factor balancing pluripotency and XEN differentiation [0.03%]
ESRRB是与细胞周期相关的因子，可平衡多能性和XEN分化
Sapir Herchcovici Levy,Sharon Feldman Cohen,Lee Arnon et al.
Sapir Herchcovici Levy et al.
Cell cycle and differentiation decisions are linked; however, the underlying principles that drive these decisions are unclear. Here, we combined cell-cycle reporter system and single-cell RNA sequencing (scRNA-seq) profiling to study the t...
Derivation of functional trophoblast stem cells from primed human pluripotent stem cells [0.03%]
从培养的人多能干细胞中分离功能滋养层干细胞
Francesca Soncin,Robert Morey,Tony Bui et al.
Francesca Soncin et al.
Trophoblast stem cells (TSCs) have recently been derived from human embryos and early-first-trimester placenta; however, aside from ethical challenges, the unknown disease potential of these cells limits their scientific utility. We have pr...
Ripk3 signaling regulates HSCs during stress and represses radiation-induced leukemia in mice [0.03%]
Ripk3信号调节压力下的造血干细胞并抑制小鼠放射诱导的白血病
Lei Zhang,Huacheng Luo,Hong-Min Ni et al.
Lei Zhang et al.
Receptor-interacting protein kinase 3 (Ripk3) is one of the critical mediators of inflammatory cytokine-stimulated signaling. Here we show that Ripk3 signaling selectively regulates both the number and the function of hematopoietic stem cel...
Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids [0.03%]
人诱导多能干细胞来源皮肤类器官中表皮基底膜的形成与功能分析
Veronika Ramovs,Hans Janssen,Ignacia Fuentes et al.
Veronika Ramovs et al.
Human induced pluripotent stem cell (hiPSC)-derived hair-bearing skin organoids offer exciting new possibilities for modeling diseases like epidermolysis bullosa (EB). These inherited diseases affect 1 in 30,000 people worldwide and result ...
APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes [0.03%]
APOE2、E3和E4同种基因来源的iPSC源星形胶质细胞中对细胞稳态、胆固醇代谢及炎症反应的调节作用不同
Sherida M de Leeuw,Aron W T Kirschner,Karina Lindner et al.
Sherida M de Leeuw et al.
Published Erratum
Stem cell reports. 2022 May 10;17(5):1229-1231. DOI:10.1016/j.stemcr.2022.03.018 2022
Response to: SARS-CoV-2 and type I interferon signaling in brain endothelial cells: Blurring the lines between friend or foe [0.03%]
SARS-CoV-2与I型干扰素信号在脑内皮细胞中的作用：是敌是友？
Susanne Krasemann,Markus Glatzel,Ole Pless
Susanne Krasemann
SARS-CoV-2 and type I interferon signaling in brain endothelial cells: Blurring the lines between friend or foe [0.03%]
脑内皮细胞中的SARS-CoV-2和I型干扰素信号：区分有益还是有害
George D Vavougios,Sotirios G Zarogiannis,Georgios Hadjigeorgiou et al.
George D Vavougios et al.
PRC1 uncomplexed [0.03%]
未复合的PRC1
Sanne Schouten,Nick Bovee,Zicong Liu et al.
Sanne Schouten et al.
Epigenetic enzymes are critically involved in gene regulation during lineage commitment. In this issue of Stem Cell Reports, Zhu et al. (2022) unravel extensive redundancy between subunits of the epigenetic regulatory Polycomb Repressive Co...
Subventricular zone adult mouse neural stem cells require insulin receptor for self-renewal [0.03%]
成人哺乳动物亚 ventricle 区神经干细胞的自我更新依赖于胰岛素受体的功能
Shravanthi Chidambaram,Fernando J Velloso,Deborah E Rothbard et al.
Shravanthi Chidambaram et al.
The insulin receptor (INSR) is an evolutionarily conserved signaling protein that regulates development and cellular metabolism. INSR signaling promotes neurogenesis in Drosophila; however, a specific role for the INSR in maintaining adult ...