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Ripk3 signaling regulates HSCs during stress and represses radiation-induced leukemia in mice

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Receptor-interacting protein kinase 3 (Ripk3) is one of the critical mediators of inflammatory cytokine-stimulated signaling. Here we show that Ripk3 signaling selectively regulates both the number and the function of hematopoietic stem cells (HSCs) during str... ...