mRNA-based generation of marmoset PGCLCs capable of differentiation into gonocyte-like cells [0.03%]
基于mRNA的生成能够分化为类似生殖细胞的食指猴PGCLC
Musashi Kubiura-Ichimaru,Christopher Penfold,Kazuaki Kojima et al.
Musashi Kubiura-Ichimaru et al.
Primate germ cell development remains largely unexplored due to limitations in sample collection and the long duration of development. In mice, primordial germ cell-like cells (PGCLCs) derived from pluripotent stem cells (PSCs) can develop ...
A feedforward loop between JAK/STAT downstream target p115 and STAT in germline stem cells [0.03%]
JAK/STAT下游目标p115与生殖干细胞中STAT之间的正反馈回路
Ruiyan Kong,Juan Li,Fuli Liu et al.
Ruiyan Kong et al.
The maintenance of germline stem cells (GSCs) is essential for tissue homeostasis. JAK/STAT signaling maintains GSC fate in Drosophila testis. However, how JAK/STAT signaling maintains male GSC fate through its downstream targets remains po...
Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model [0.03%]
人多能干细胞模型中APOE4基因型介导的星形胶质细胞对突触结构的负面影响
Hirotaka Watanabe,Rei Murakami,Kazuya Tsumagari et al.
Hirotaka Watanabe et al.
The APOE4 genotype is the strongest risk factor for the pathogenesis of sporadic Alzheimer's disease (AD), but the detailed molecular mechanism of APOE4-mediated synaptic impairment remains to be determined. In this study, we generated a hu...
Protein-encapsulated doxorubicin reduces cardiotoxicity in hiPSC-cardiomyocytes and cardiac spheroids while maintaining anticancer efficacy [0.03%]
蛋白质包封多柔比星可降低在hiPSC心肌细胞和心脏类器官中的心脏毒性并保持其抗癌功效
Madelyn Arzt,Bowen Gao,Maedeh Mozneb et al.
Madelyn Arzt et al.
The chemotherapeutic doxorubicin (DOX) detrimentally impacts the heart during cancer treatment. This necessitates development of non-cardiotoxic delivery systems that retain DOX anticancer efficacy. We used human induced pluripotent stem ce...
Integrated single cell analysis shows chronic alcohol drinking disrupts monocyte differentiation in the bone marrow [0.03%]
集成单细胞分析显示慢性酒精摄入会破坏骨髓中的单核细胞分化
Sloan A Lewis,Brianna M Doratt,Qi Qiao et al.
Sloan A Lewis et al.
Chronic heavy alcohol drinking (CHD) rewires monocytes and macrophages toward heightened inflammatory states with compromised antimicrobial defenses that persist after 1-month abstinence. To determine whether these changes are mediated thro...
Dual CRISPR-Cas3 system for inducing multi-exon skipping in DMD patient-derived iPSCs [0.03%]
用于诱导DMD患者诱导多外显子跳跃的双CRISPR-Cas3系统
Yuto Kita,Yuya Okuzaki,Youichi Naoe et al.
Yuto Kita et al.
To restore dystrophin protein in various mutation patterns of Duchenne muscular dystrophy (DMD), the multi-exon skipping (MES) approach has been investigated. However, only limited techniques are available to induce a large deletion to cove...
Spatiotemporal cell junction assembly in human iPSC-CM models of arrhythmogenic cardiomyopathy [0.03%]
人多潜能干细胞心肌细胞模型中遗传性心律失常性心肌病的时空细胞连接组装现象
Sean L Kim,Michael A Trembley,Keel Yong Lee et al.
Sean L Kim et al.
Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder that causes life-threatening arrhythmias and myocardial dysfunction. Pathogenic variants in Plakophilin-2 (PKP2), a desmosome component within specialized cardiac cell jun...
DOT1L regulates lung developmental epithelial cell fate and adult alveolar stem cell differentiation after acute injury [0.03%]
DOT1L调节肺发育上皮细胞命运和急性损伤后成人肺泡干细胞分化
Shanru Li,Derek Liberti,Su Zhou et al.
Shanru Li et al.
AT2 cells harbor alveolar stem cell activity in the lung and can self-renew and differentiate into AT1 cells during homeostasis and after injury. To identify epigenetic pathways that control the AT2-AT1 regenerative response in the lung, we...
A novel protocol to derive cervical motor neurons from induced pluripotent stem cells for amyotrophic lateral sclerosis [0.03%]
一种新的诱导多能干细胞分化颈脊髓运动神经元的方法用于研究肌萎缩侧索硬化症
Meimei Yang,Min Liu,Yajaira Feller Sánchez et al.
Meimei Yang et al.
Sporadic amyotrophic lateral sclerosis (sALS) is the majority of ALS, and the lack of appropriate disease models has hindered its research. Induced pluripotent stem cell (iPSC) technology now permits derivation of iPSCs from somatic cells o...
Country-specific regulation and international standardization of cell-based therapeutic products derived from pluripotent stem cells [0.03%]
基于多能干细胞的细胞治疗产品的国家标准和国际标准化及各国规定
Takamasa Hirai,Satoshi Yasuda,Akihiro Umezawa et al.
Takamasa Hirai et al.
Currently, many types of cell-based therapeutic products (CTPs) derived from pluripotent stem cells (PSCs) are being developed in a lot of countries, some of which are in clinical trial stages. CTPs are classified differently in different c...