Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model
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The APOE4 genotype is the strongest risk factor for the pathogenesis of sporadic Alzheimer's disease (AD), but the detailed molecular mechanism of APOE4-mediated synaptic impairment remains to be determined. In this study, we generated a human astrocyte model ... ...
