A critical role of retinoic acid concentration for the induction of a fully human-like atrial action potential phenotype in hiPSC-CM [0.03%]
全人源化诱导多能干细胞心脏细胞模型中视黄酸浓度对心房动作电位形成的关键作用研究
Carl Schulz,Muhammed Sönmez,Julia Krause et al.
Carl Schulz et al.
Retinoic acid (RA) induces an atrial phenotype in human induced pluripotent stem cells (hiPSCs), but expression of atrium-selective currents such as the ultrarapid (IKur) and acetylcholine-stimulated K+ current is variable and less than in ...
Enrichment of FGF8-expressing cells from neurally induced human pluripotent stem cell cultures [0.03%]
从神经诱导的人类多能干细胞培养物中富集FGF8表达细胞
Nils Offen,Alina Filatova,Ulrike A Nuber
Nils Offen
In early vertebrate development, organizer regions-groups of cells that signal to and thereby influence neighboring cells by secreted morphogens-play pivotal roles in the establishment and maintenance of cell identities within defined tissu...
Nerea Cuesta-Gomez,Kevin Verhoeff,Nidheesh Dadheech et al.
Nerea Cuesta-Gomez et al.
Generation of pure pancreatic progenitor (PP) cells is critical for clinical translation of stem cell-derived islets. Herein, we performed PP differentiation with and without AKT/P70 inhibitor AT7867 and characterized the resulting cells at...
Is epigenome editing non-inheritable? Implications for ethics and the regulation of human applications [0.03%]
表观遗传编辑无法遗传吗？伦理及人类应用监管的启示
Mitsuru Sasaki-Honda,Kyoko Akatsuka,Tsutomu Sawai
Mitsuru Sasaki-Honda
Epigenome editing offers ethical advantages with non-inheritable gene expression control. However, concerns arise regarding potential transgenerational effects in humans. Ethical and regulatory evaluation is crucial, considering recent adva...
Mowat-Wilson syndrome factor ZEB2 controls early formation of human neural crest through BMP signaling modulation [0.03%]
ZEB2基因通过调节BMP信号调控人类神经嵴早期发育
Rebekah M Charney,Maneeshi S Prasad,Czarina Juan-Sing et al.
Rebekah M Charney et al.
Mowat-Wilson syndrome is caused by mutations in ZEB2, with patients exhibiting characteristics indicative of neural crest (NC) defects. We examined the contribution of ZEB2 to human NC formation using a model based on human embryonic stem c...
Businesses marketing purported stem cell treatments and exosome therapies for COVID-19: An analysis of direct-to-consumer online advertising claims [0.03%]
面向消费者的直接在线广告宣传销售用于治疗COVID-19的所谓干细胞和外泌体疗法及相关分析
Leigh Turner,Juan Ramon Martinez Jr,Shemms Najjar et al.
Leigh Turner et al.
We identified 38 businesses advertising purported stem cell interventions and exosome products for COVID-19. These companies operated or facilitated access to 60 clinics. More than 75% of these clinics were based in the United States and Me...
Reconstituted ovaries self-assemble without an ovarian surface epithelium [0.03%]
无卵巢表面上皮的卵泡自我组装重建卵巢组织
Enrique Sosa,Sinthia Kabir Mumu,Christian C Alvarado et al.
Enrique Sosa et al.
Three-dimensional (3D) stem cell models of the ovary have the potential to benefit women's reproductive health research. One such model, the reconstituted ovary (rOvary) self-assembles with pluripotent stem cell-derived germ cells creating ...
An expedition in the jungle of pluripotent stem cells of non-human primates [0.03%]
灵长类多能干细胞的 jungla 概念之旅
Preeyanan Anwised,Ratree Moorawong,Worawalan Samruan et al.
Preeyanan Anwised et al.
For nearly three decades, more than 80 embryonic stem cell lines and more than 100 induced pluripotent stem cell lines have been derived from New World monkeys, Old World monkeys, and great apes. In this comprehensive review, we examine the...
The multi-lineage transcription factor ISL1 controls cardiomyocyte cell fate through interaction with NKX2.5 [0.03%]
ISL1通过与NKX2.5的相互作用控制心肌细胞的命运走向
Bonnie E J Maven,Casey A Gifford,Melanie Weilert et al.
Bonnie E J Maven et al.
Congenital heart disease often arises from perturbations of transcription factors (TFs) that guide cardiac development. ISLET1 (ISL1) is a TF that influences early cardiac cell fate, as well as differentiation of other cell types including ...
A human in vitro neuronal model for studying homeostatic plasticity at the network level [0.03%]
一种用于在细胞水平上研究体内神经元稳态可塑性的方法
Xiuming Yuan,Sofía Puvogel,Jon-Ruben van Rhijn et al.
Xiuming Yuan et al.
Mechanisms that underlie homeostatic plasticity have been extensively investigated at single-cell levels in animal models, but are less well understood at the network level. Here, we used microelectrode arrays to characterize neuronal netwo...