O-GlcNAcase regulates pluripotency states of human embryonic stem cells [0.03%]
O-GlcNAc酶通过调节多能性网络来调控人胚胎干细胞的多能状态
Qianyu Liu,Cheng Chen,Zhiya Fan et al.
Qianyu Liu et al.
Understanding the regulation of human embryonic stem cells (hESCs) pluripotency is critical to advance the field of developmental biology and regenerative medicine. Despite the recent progress, molecular events regulating hESC pluripotency,...
Self-assembling 3D vessel-on-chip model with hiPSC-derived astrocytes [0.03%]
一种用hiPSC来源的星形胶质细胞自组装构建的三维血管芯片模型
Dennis M Nahon,Marc Vila Cuenca,Francijna E van den Hil et al.
Dennis M Nahon et al.
Functionality of the blood-brain barrier (BBB) relies on the interaction between endothelial cells (ECs), pericytes, and astrocytes to regulate molecule transport within the central nervous system. Most experimental models for the BBB rely ...
A dual-color PAX7 and MYF5 in vivo reporter to investigate muscle stem cell heterogeneity in regeneration and aging [0.03%]
一种用于探究再生和衰老过程中肌肉干细胞异质性的PAX7和MYF5体内报告系统
Sara Ancel,Joris Michaud,Federico Sizzano et al.
Sara Ancel et al.
Increasing evidence suggests that the muscle stem cell (MuSC) pool is heterogeneous. In particular, a rare subset of PAX7-positive MuSCs that has never expressed the myogenic regulatory factor MYF5 displays unique self-renewal and engraftme...
Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons [0.03%]
C9ORF72 HRE 诱导的多能干细胞来源运动和感觉神经元内的细胞及轴突转运异常表型研究
Jakub Scaber,Iona Thomas-Wright,Alex J Clark et al.
Jakub Scaber et al.
Induced pluripotent stem cell (iPSC)-derived motor neurons (MNs) from patients with amyotrophic lateral sclerosis (ALS) and the C9ORF72 hexanucleotide repeat expansion (HRE) have multiple cellular phenotypes, but which of these accurately r...
In and out: Benchmarking in vitro, in vivo, ex vivo, and xenografting approaches for an integrative brain disease modeling pipeline [0.03%]
脑疾病整合建模流程的体外、体内、离体和异种移植方法基准测试
Marlene F Pereira,Reinald Shyti,Giuseppe Testa
Marlene F Pereira
Human cellular models and their neuronal derivatives have afforded unprecedented advances in elucidating pathogenic mechanisms of neuropsychiatric diseases. Notwithstanding their indispensable contribution, animal models remain the benchmar...
Anticipating in vitro gametogenesis: Hopes and concerns for IVG among diverse stakeholders [0.03%]
体外生殖细胞的发生：不同利益相关者对IVG的期望与顾虑
Anne Le Goff,Robbin Jeffries Hein,Ariel N Hart et al.
Anne Le Goff et al.
In vitro gametogenesis (IVG), the reconstitution of germ cell development in vitro, is an emerging stem cell-based technology with profound implications for reproductive science. Despite researchers' long-term goals for future clinical appl...
Disruption of common ocular developmental pathways in patient-derived optic vesicle models of microphthalmia [0.03%]
基于小眼症患者视泡衍生模型的常见眼部发育途径中断研究
Jonathan Eintracht,Nicholas Owen,Philippa Harding et al.
Jonathan Eintracht et al.
Genetic perturbations influencing early eye development can result in microphthalmia, anophthalmia, and coloboma (MAC). Over 100 genes are associated with MAC, but little is known about common disease mechanisms. In this study, we generated...
Human pluripotent stem cell-derived kidney organoids reveal tubular epithelial pathobiology of heterozygous HNF1B-associated dysplastic kidney malformations [0.03%]
人多能干细胞来源的肾脏类器官揭示了异源性HNF1B相关肾畸形的管状上皮病理生物学
Ioannis Bantounas,Kirsty M Rooney,Filipa M Lopes et al.
Ioannis Bantounas et al.
Hepatocyte nuclear factor 1B (HNF1B) encodes a transcription factor expressed in developing human kidney epithelia. Heterozygous HNF1B mutations are the commonest monogenic cause of dysplastic kidney malformations (DKMs). To understand thei...
Stemformatics data portal enables transcriptional benchmarking of lab-derived myeloid cells [0.03%]
Stemformatics数据门户可对实验室衍生的髓样细胞进行转录基准测试
Jarny Choi,Suzanne K Butcher,Paul W Angel et al.
Jarny Choi et al.
Stemformatics.org has been serving the stem cell research community for over a decade, by making it easy for users to find and view transcriptional profiles of pluripotent and adult stem cells and their progeny, comparing data derived from ...
Forced LMX1A expression induces dorsal neural fates and disrupts patterning of human embryonic stem cells into ventral midbrain dopaminergic neurons [0.03%]
LMX1A强制表达诱导人胚胎干细胞向背侧神经命运分化并破坏腹中脑多巴胺能神经元分化的模式化过程
Pedro Rifes,Janko Kajtez,Josefine Rågård Christiansen et al.
Pedro Rifes et al.
The differentiation of human pluripotent stem cells into ventral mesencephalic dopaminergic (DA) fate is relevant for the treatment of Parkinson's disease. Shortcuts to obtaining DA cells through direct reprogramming often include forced ex...