Effect of Notch1 signaling on muscle engraftment and maturation from pluripotent stem cells [0.03%]
Notch1信号对多能干细胞肌肉植入和成熟的影响
Aline M S Yamashita,Bayardo I Garay,Hyunkee Kim et al.
Aline M S Yamashita et al.
Pax3-induced pluripotent stem cell-derived myogenic progenitors display an embryonic molecular signature but become postnatal upon transplantation. Because this correlates with upregulation of Notch signaling, here we probed whether NOTCH1 ...
Microvessel co-transplantation improves poor remuscularization by hiPSC-cardiomyocytes in a complex disease model of myocardial infarction and type 2 diabetes [0.03%]
微血管共移植可改善心肌梗死和2型糖尿病复杂疾病模型的hiPSC心肌细胞移植后肌浆网形成不良的现象
Xuetao Sun,Jun Wu,Omar Mourad et al.
Xuetao Sun et al.
People with type 2 diabetes (T2D) are at a higher risk for myocardial infarction (MI) than age-matched healthy individuals. Here, we studied cell-based cardiac regeneration post MI in T2D rats modeling the co-morbid conditions in patients w...
A novel rapalog shows improved safety vs. efficacy in a human organoid model of polycystic kidney disease [0.03%]
一种新型雷帕霉素类似物在多囊肾病的人类器官模型中表现出更好的安全性和有效性
Ramila E Gulieva,Parvaneh Ahmadvand,Benjamin S Freedman
Ramila E Gulieva
The mammalian target of rapamycin (mTOR) pathway is a therapeutic target in polycystic kidney disease (PKD), but mTOR inhibitors such as everolimus have failed to show efficacy at tolerated doses in clinical trials. Here, we introduce AV457...
Transplantation of genome-edited retinal organoids restores some fundamental physiological functions coordinated with severely degenerated host retinas [0.03%]
基因编辑视网膜类器官移植可恢复与重度退行性视网膜协调的一些基本生理功能
Mikiya Watanabe,Takayuki Yamada,Chieko Koike et al.
Mikiya Watanabe et al.
We have previously shown that the transplantation of stem cell-derived retinal organoid (RO) sheets into animal models of end-stage retinal degeneration can lead to host-graft synaptic connectivity and restoration of vision, which was furth...
Efficient differentiation of human iPSCs into Leydig-like cells capable of long-term stable secretion of testosterone [0.03%]
一种可长期稳定分泌睾丸素的类Leydig细胞的人多能干细胞高效分化方法
Katsuya Sato,Michiyo Koyanagi-Aoi,Keiichiro Uehara et al.
Katsuya Sato et al.
Late-onset hypogonadism (LOH) syndrome is characterized by age-related testosterone deficiency and negatively affects the quality of life of older men. A promising therapeutic approach for LOH syndrome is transplantation of testosterone-pro...
Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation [0.03%]
选择性激活FZD2和FZD7在中胚层分化过程中的非冗余功能研究
Rony Chidiac,Andy Yang,Elli Kubarakos et al.
Rony Chidiac et al.
During gastrulation, Wnt-β-catenin signaling dictates lineage bifurcation generating different mesoderm cell types. However, the specific role of Wnt receptors in mesoderm specification remains elusive. Using selective Frizzled (FZD) and L...
Janet Rossant
Janet Rossant
Jing Guo,Runxia Lin,Jinpeng Liu et al.
Jing Guo et al.
Guinea pigs are valuable models for human disease research, yet the lack of established pluripotent stem cell lines has limited their utility. In this study, we isolate and characterize guinea pig epiblast stem cells (gpEpiSCs) from post-im...
Dual inhibition of MAPK/ERK and BMP signaling induces entorhinal-like identity in mouse ESC-derived pallial progenitors [0.03%]
MAPK/ERK和BMP信号的双重抑制可诱导小鼠ES细胞来源皮层祖细胞向内嗅皮质谱系分化
Fabrizio Tonelli,Ludovico Iannello,Stefano Gustincich et al.
Fabrizio Tonelli et al.
The mechanisms that determine distinct embryonic pallial identities remain elusive. The central role of Wnt signaling in directing dorsal telencephalic progenitors to the isocortex or hippocampus has been elucidated. Here, we show that time...
From responsibility to responsibilization in stem cell research: An ethical framework [0.03%]
从责任到责任化：干细胞研究的伦理框架
Lars S Assen,Annelien L Bredenoord,Rosario Isasi et al.
Lars S Assen et al.
Adopting a responsibilization approach can further improve the ethical conduct of stem cell (SC) research and applications. This approach helps align new and existing solutions for ethical implications by focusing on equipping SC researcher...