A humanized engineered heart tissue platform for cardiotoxicity assessment [0.03%]
一种用于检测心脏毒性的工程化人心肌组织平台
Yao-Hui Sun,Daphne A Diloretto,Hillary K J Kao et al.
Yao-Hui Sun et al.
Cardiovascular diseases (CVDs), many of which are influenced by exposure to environmental xenobiotics, lack physiologically relevant in vitro models for cardiotoxicity assessment. Although some pollutants have established associations with ...
Diversity of cortical progenitors directs neuronal layer formation and regional glial patterning [0.03%]
皮质前体的多样性指导神经节层形成和区域胶质模式化
Ana Cristina Ojalvo-Sanz,María Figueres-Oñate,Sonsoles Barriola et al.
Ana Cristina Ojalvo-Sanz et al.
How distinct cortical progenitor types and their temporal differences influence neuronal and glial development remains a key question in neurobiology. While radial glial cells (RGCs) are well-established as neural progenitors (NPCs), NG2+NP...
Exosome-Mediated Benefits of Cell Therapy in Mouse and Human Models of Duchenne Muscular Dystrophy [0.03%]
小鼠和杜氏肌营养不良症患者模型中细胞治疗的外泌体介导益处
Mark A Aminzadeh,Russell G Rogers,Mario Fournier et al.
Mark A Aminzadeh et al.
Published Erratum
Stem cell reports. 2026 Mar 13:102889. DOI:10.1016/j.stemcr.2026.102889 2026
Cellular immunotherapy for COVID-19-induced acute respiratory distress syndrome: Results of the CIRCA-19 phase 1 safety and phase 2 randomized controlled trials [0.03%]
针对COVID-19所致急性呼吸窘迫综合征的细胞免疫治疗:CIRCA-19一期安全性及二期随机对照试验结果
Shane W English,Dean A Fergusson,Manoj Mathew Lalu et al.
Shane W English et al.
The ability of immunomodulatory mesenchymal stromal cells (MSCs) to improve COVID-19-associated acute respiratory distress syndrome (ARDS) in clinical trials is uncertain. We assessed whether freshly cultured umbilical cord (UC)-derived MSC...
New legal category of 'advanced regenerative medicine treatment' in Korea's amended regenerative medicine law: comparative lessons from Japan [0.03%]
韩国《再生医药品法》修订后新增“先进再生医学治疗”新法域——日本法制的启示与借鉴
Jinah Yoon,Sukhyang Lee,Jung-Hyun Kim
Jinah Yoon
South Korea's Act on the Safety of and Support for Advanced Regenerative Medicine and Advanced Biological Products, enacted in 2019, was recently amended. This article examines the new advanced regenerative medicine treatment (ARMT) categor...
Nuclear Lipin1 recruits HDAC2 to epigenetically repress SREBP1-dependent lipid synthesis and myelination in hypoxic preterm white matter injury [0.03%]
核Lipin1通过募集HDAC2表观遗传抑制SREBP1依赖性脂质合成和早产白质缺氧损伤中的髓鞘形成
Xinyu Li,Xiaoyu Yao,Chunjie Guo et al.
Xinyu Li et al.
Preterm white matter injury (PWMI) causes lasting neurological deficits by blocking oligodendrocyte precursor cell (OPC) differentiation. Perinatal hypoxia suppresses mechanistic target of rapamycin complex 1 (mTORC1), essential for OPC mat...
Selective Cav1.3 inhibition promotes survival of transplanted dopaminergic neurons via the CaMKII-p65-p53 pathway [0.03%]
选择性抑制Cav1.3通道通过CaMKII-p65-p53信号通路促进移植黑质多巴胺能神经元的存活
Qingyuan Y Tang,Jing Sun,Jun Xue et al.
Qingyuan Y Tang et al.
Poor survival of transplanted midbrain dopaminergic neurons (mDANs) remains a key barrier for stem cell-based Parkinson's disease (PD) therapy. Cav1.3-containing L-type calcium channel blockers have been shown to prevent native mDAN loss in...
Genome-edited safe and immune-evasive human pluripotent cells: Potential solution for allogeneic therapies [0.03%]
用于同种异体治疗的基因组编辑安全和免疫逃避的人多能细胞：潜在解决方案
Vivian Tam,Nicole Ching Man Wong,Andrew Chung Hin Poon et al.
Vivian Tam et al.
We used an embryonic stem cell line (H1) engineered for immune-evading properties to avoid rejection ("AlloAccept") and equipped with a "SafeCell" (SC) kill-switch to eliminate aberrantly proliferating cells. Utilizing a humanized immune sy...
Delayed forebrain excitatory and inhibitory neurogenesis in STRADA-related megalencephaly via mTOR hyperactivity [0.03%]
STRADA相关巨脑症通过mTOR过度活化延迟大脑兴奋性和抑制性神经元生成
Tong Pan,Grace Lin,Xuan Li et al.
Tong Pan et al.
Biallelic pathogenic variants in STRADA (STE20-related adaptor alpha), an upstream regulator of the mechanistic target of rapamycin (mTOR) pathway, result in megalencephaly, drug-resistant epilepsy, and severe intellectual disability. This ...
Genomic characterization of sub-populations in human pluripotent stem cell-derived retinal progenitor cells driving retinal lamination [0.03%]
人多能干细胞来源视网膜祖细胞亚群的基因组特征刻画及其对视网膜板层结构形成的作用机制研究
Yasuaki Iwama,Tomohiro Masuda,Mika Yoshimura et al.
Yasuaki Iwama et al.
The mechanism underlying retinal spheroid layer formation was investigated using Rax::GFP-positive retinal progenitor cells from human embryonic stem cell-derived retinal organoids. Single-cell RNA sequencing suggested the earlier cell-cycl...