Nuclear Lipin1 recruits HDAC2 to epigenetically repress SREBP1-dependent lipid synthesis and myelination in hypoxic preterm white matter injury
{{output}}
Preterm white matter injury (PWMI) causes lasting neurological deficits by blocking oligodendrocyte precursor cell (OPC) differentiation. Perinatal hypoxia suppresses mechanistic target of rapamycin complex 1 (mTORC1), essential for OPC maturation. We identify... ...
