CTPS1 modulates mitophagy to propel diffuse large B-cell lymphoma via reshaping CEPT1-mediated phospholipid metabolism [0.03%]
Chunyu Shang,Kaixin Du,Yixin Zou et al.
Chunyu Shang et al.
Despite effective first-line regimens, some patients with diffuse large B-cell lymphoma (DLBCL) still experience relapse or resistance, emphasizing the urgent need for innovative treatment approaches. Cytidine triphosphate synthase 1 (CTPS1...
ACOD-itaconate in macrophage attenuates oxidative stress and inflammation in benign airway stenosis by upregulating and transferring FTH1 [0.03%]
YiLin Chen,ChengFei Xu,Tao Luo et al.
YiLin Chen et al.
The oxidative stress of macrophage plays pivotal roles of acute and chronic inflammation and chronic fibrotic phases, in which the metabolic mechanism needs to be further explored. In our research, multi-omics analyses of human and murine d...
Qian Xue,Ziyuan Chen,Jiao Yang et al.
Qian Xue et al.
Copper is an essential trace element that governs diverse cellular functions and influences cell fate. However, how cells adapt to copper deprivation remains poorly understood. Here, we identify a copper-ferroptosis regulatory axis mediated...
Fengjing Yang,Song Tong,Junhao Wan et al.
Fengjing Yang et al.
Primary graft dysfunction (PGD) caused by ischemia-reperfusion injury (IRI) is a major complication after lung transplantation, yet its underlying mechanisms remain unclear. Triggering receptor expressed on myeloid cells 1 (Trem1) is an imp...
Pooja Pradhan,Roberta Foresti,Roberto Motterlini et al.
Pooja Pradhan et al.
Nitric oxide (NO) is a key signaling gas that is involved in a wide range of physiological and pathophysiological processes. NO signaling is closely linked to its interactions with heme, an abundant iron-containing tetrapyrrole in the organ...
Histone H3K9 lactylation activates the TXNIP/NLRP3 pathway to drive macrophage inflammation after spinal cord injury [0.03%]
Chaoran Shi,Feifei Yuan,Xingyi Chen et al.
Chaoran Shi et al.
Spinal cord injury (SCI) induces metabolic and immune disruptions that impede tissue repair. However, the underlying mechanisms are poorly understood. In this study, we identified lactate accumulation as a critical driver of macrophage-medi...
Breath-by-breath quantification of inhaled nitric oxide absorption and modeling of methemoglobin kinetics [0.03%]
Run Dong,Hatus V Wanderley,Elisa Mereto et al.
Run Dong et al.
Recent studies uncovered extrapulmonary effects of inhaled nitric oxide (NO) therapy. However, no method exists to quantify NO absorption. This study developed a breath-by-breath system for inhaled NO absorption measurement, which consists ...
USP20 governs tyrosine kinase inhibitors resistance through ferroptosis evasion by targeting GPX4 in cancers [0.03%]
Yuzhao Wang,Bo Liu,Yanxin Zhuang et al.
Yuzhao Wang et al.
Tyrosine kinase inhibitors (TKIs) including sunitinib and sorafenib remain first-line therapies for advanced renal cell carcinoma (RCC) and lung cancer (LC), but their efficacy is limited by acquired resistance. By characterizing metabolic ...
The regulation of mitochondrial ferritin on mitochondrial redox balance is essential to cell fate decision [0.03%]
Yuanyuan Liu,Yan-Zhong Chang
Yuanyuan Liu
Mitochondrial ferritin (FtMt), first identified by Levi et al., is an iron-storage protein with high homology with cytoplasmic ferritin. It is mainly expressed in metabolically active tissues and exhibits distinct physiological and biochemi...
Formation of a reducing microenvironment and regulation of protein supersulfidation by gut microbial supersulfides [0.03%]
Jun Uchiyama,Yoshimi Shimizu,Takamitsu Unoki et al.
Jun Uchiyama et al.
Supersulfides, sulfur species containing catenated sulfur atoms, are potent reducing agents produced by diverse organisms. Although their intracellular functions are increasingly recognized, the ecological and physiological importance of gu...