S100A9 modulates USP7-mediated stabilization of NCOA4 to promote ferroptosis in sepsis-associated acute lung injury [0.03%]
S100A9通过调节USP7介导的NCOA4稳定促进脓毒症相关急性肺损伤中铁死亡发生
Yi Wei,Angran Gu,Bailun Wang et al.
Yi Wei et al.
Sepsis-associated acute lung injury (SALI) is driven by dysregulated macrophage activation; however, mechanisms linking innate immune signaling to cell death remain elusive. Emerging evidence implicates ferroptosis, fueled by NCOA4-mediated...
XRCC1 deficiency drives telomeric chromatin leakage, inflammatory signalling and senescence [0.03%]
DNA修复蛋白XRCC1缺陷导致端粒染色质泄漏、炎性信号传导和衰老现象
Anna Piscone,Francesca Gorini,Susanna Ambrosio et al.
Anna Piscone et al.
Genome integrity is constantly challenged by oxidative DNA damage, which, if left unrepaired, can result in replication stress, chromosomal instability, and tumorigenesis. The base excision repair (BER) pathway is essential for resolving ox...
An integrative analysis of elementomics and oxidation-reduction potentials identifies redox-related metals associated with coronary artery disease and post-PCI outcomes in type 2 diabetic patients [0.03%]
元素组学与氧化还原电位的综合分析鉴定出与2型糖尿病患者冠状动脉疾病和经皮冠状动脉介入术后转归相关的红ox金属元素
Zi-Qi Fang,Bing Wang,Ning-Hua Cui et al.
Zi-Qi Fang et al.
Exposure to metals has been associated with elevated oxidative stress, which may contribute to diabetic macrovascular complications. However, current methods for evaluating oxidative stress, which mainly rely on quantifying individual bypro...
Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stress [0.03%]
氧化还原失衡决定了视杆细胞在衰老和压力期间依赖GOT1还是GOT2维持健康
Meini Chen,Eric Weh,Moloy T Goswami et al.
Meini Chen et al.
Photoreceptor (PR) loss causes vision loss in many blinding diseases and effective therapies to prevent this cell loss are lacking. Aspartate aminotransferases (GOTs), located in the cytosol (GOT1) and mitochondria (GOT2), are key component...
BCKDK protects against obesity-induced cardiac remodelling and dysfunction by alleviating mitochondrial oxidative stress and ROS-driven MAPK signalling [0.03%]
BCKDK通过减轻线粒体氧化应激和ROS驱动的MAPK信号传导来保护肥胖引起的心脏重塑和功能障碍
Yu Liu,Ming Ma,Yan Guo et al.
Yu Liu et al.
Aims: Impaired branched-chain amino acid (BCAA) catabolism has been implicated in obesity cardiomyopathy (OCM), and systemic inhibition of branched-chain ketoacid dehydrogenase kinase (BCKDK), a key negative regulator of ...
PARP1 rewires neuroinflammatory and redox metabolism associated with reactive neuroglia in neuropathic pain [0.03%]
PARP1重塑神经炎症和与神经病理性疼痛活化神经胶质相关的氧化代谢
Simona Denaro,Simona D&#x;Aprile,Anna Gervasi et al.
Simona Denaro et al.
Neuroinflammation, oxidative stress and metabolic dysfunction are co-dependent drivers of neuropathic pain, jointly sustaining reactive gliosis and spinal sensitization. The interplay among neuroinflammation, redox imbalance, and metabolic ...
TRPV4 drives macrophage pyroptosis via mitochondrial dysfunction and mtROS-dependent NLRP3 inflammasome activation in acute lung injury [0.03%]
TRPV4通过线粒体功能障碍和线粒体ros依赖的Nlrp3炎性小体活化驱动急性肺损伤中的巨噬细胞pyroptosis
Lan Luo,Xiaofang Yang,Shuyuan Yi et al.
Lan Luo et al.
Biomarkers and potential subtypes of acute mountain sickness: A state-of-the-science review [0.03%]
急性高原病生物标志物和潜在亚型的现况分析——系统综述
Johannes Burtscher,Roxana Ehlers,Nicolas Bourdillon et al.
Johannes Burtscher et al.
Exposure to high altitude can cause acute mountain sickness (AMS) characterized by headache, gastrointestinal symptoms, dizziness and fatigue, which may progress to life-threatening conditions like high-altitude cerebral edema (HACE). Altho...
Reciprocal regulation between JOSD2 and CREB1 drives aerobic glycolysis and progression of renal cell carcinoma [0.03%]
JOSD2与CREB1的互调调节驱动肾细胞癌的糖酵解和进展
Qian Zhang,Hao Yuan,Haiyun Xiong et al.
Qian Zhang et al.
Dysregulated aerobic glycolysis represents a defining metabolic feature of renal cell carcinoma (RCC), yet the regulatory networks driving this metabolic shift remain incompletely elucidated. In the present study, we found that the deubiqui...
Compensation for impaired sensing of selenoprotein deficiency by alternative cysteine residues in KEAP1 [0.03%]
KEAP1中替代半胱氨酸残基对硒蛋白缺乏感应受损的补偿作用
Miu Sato,Takuya Iijima,Takafumi Suzuki et al.
Miu Sato et al.
The KEAP1-NRF2 system is a master regulator of cellular defense against oxidative and electrophilic stresses. Cysteine residues within KEAP1 function as critical stress sensors. While KEAP1-Cys151 is a well-established sensor for electrophi...