Compensation for impaired sensing of selenoprotein deficiency by alternative cysteine residues in KEAP1
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The KEAP1-NRF2 system is a master regulator of cellular defense against oxidative and electrophilic stresses. Cysteine residues within KEAP1 function as critical stress sensors. While KEAP1-Cys151 is a well-established sensor for electrophilic NRF2 activators,... ...
