Biological function, topology, and quantification of plasma membrane Ceramide [0.03%]
生物膜甘油二酯的生物学功能，拓扑和定量分析
Daniel Canals,Yusuf A Hannun
Daniel Canals
Over the past 30 years, a growing body of evidence has revealed the regulatory role of the lipid ceramide in various cellular functions. The structural diversity of ceramide, resulting in numerous species, and its distinct distribution with...
Y Wang,M J O Wakelam,V A Bankaitis et al.
Y Wang et al.
Phospholipase D (PLD) hydrolyses phosphatidylcholine (PtdCho) to produce free choline and the critically important lipid signaling molecule phosphatidic acid (PtdOH). Since the initial discovery of PLD activities in plants and bacteria, PLD...
IP8: A quantitatively minor inositol pyrophosphate signaling molecule that punches above its weight [0.03%]
IP8：一种数量上相对较少的肌醇焦磷酸信号分子，作用却不可忽视
Chunfang Gu,Xingyao Li,Guangning Zong et al.
Chunfang Gu et al.
The inositol pyrophosphates (PP-IPs) are specialized members of the wider inositol phosphate signaling family that possess functionally significant diphosphate groups. The PP-IPs exhibit remarkable functionally versatility throughout the eu...
Sonia Raveena Lourdes,Rajendra Gurung,Saveen Giri et al.
Sonia Raveena Lourdes et al.
Phosphoinositides are a minor group of membrane-associated phospholipids that are transiently generated on the cytoplasmic leaflet of many organelle membranes and the plasma membrane. There are seven functionally distinct phosphoinositides,...
Millie Xin Barbernitz,Daniel M Raben
Millie Xin Barbernitz
Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the ATP-dependent conversion of diacylglycerol (DAG) to phosphatidic acid (PtdOH). A common approach to examine the activity of these enzymes relys on a radiometric assay (...
Structural basis for the conserved roles of PI4KA and its regulatory partners and their misregulation in disease [0.03%]
PI4KA及其调控伙伴在保守功能及其疾病中的失调的结构基础
Sushant Suresh,John E Burke
Sushant Suresh
The type III Phosphatidylinositol 4-kinase alpha (PI4KA) is an essential lipid kinase that is a master regulator of phosphoinositide signalling at the plasma membrane (PM). It produces the predominant pool of phosphatidylinositol 4-phosphat...
Miguel Martin-Salgado,Ane Ochoa-Echeverría,Isabel Mérida
Miguel Martin-Salgado
Cancer still represents the second leading cause of death right after cardiovascular diseases. According to the World Health Organization (WHO), cancer provoked around 10 million deaths in 2020, with lung and colon tumors accounting for the...
Ablation of diacylglycerol kinase ε promotes whitening of brown adipose tissue under high fat diet feeding [0.03%]
DGKE敲除通过促进高脂饮食诱导的棕色脂肪白色化改善代谢健康
Tomoyuki Nakano,Ayako Suzuki,Kaoru Goto
Tomoyuki Nakano
Adipose tissue (AT) comprises distinct fat depots such as white AT and brown AT. White and brown adipocytes exhibit different morphological and physiological properties. White adipocytes containing large single lipid droplet (LD) provide en...
Seon Hyang Park,Ji Hyeon Kang,Yoe-Sik Bae
Seon Hyang Park
Phospholipase D (PLD) is an enzyme that catalyzes the hydrolysis of phosphatidylcholine into phosphatidic acid and free choline. In mammals, PLD exists in two well-characterized isoforms, PLD1 and PLD2, and it plays pivotal roles as signali...
Proteomic and yeast 2-hybrid screens to identify PTEN binding partners [0.03%]
PTEN结合蛋白的蛋白质组及酵母双杂交筛选
Priyanka Tibarewal,Laura Spinelli,Helene Maccario et al.
Priyanka Tibarewal et al.
PTEN is a phosphoinositide lipid phosphatase and an important tumour suppressor protein. PTEN function is reduced or lost in around a third of all human cancers through diverse mechanisms, from gene deletion to changes in the function of pr...