Coordinated inositide lipid-phosphatase activities of synaptojanin modulates actin cytoskeleton organization [0.03%]
双信使脂质磷酸酶活性调控肌动蛋白细胞骨架的组织结构
Tong Zhang,Andrew T Hale,Shuling Guo et al.
Tong Zhang et al.
Synaptojanin proteins are evolutionarily conserved regulators of vesicle transport and membrane homeostasis. Disruption of synaptojanin function has been implicated in a wide range of neurological disorders. Synaptojanins act as dual-functi...
Mechanistic insight on the role of iRhom2-TNF-α-BAFF signaling pathway in various autoimmune disorders [0.03%]
iRhom2-TNF-α-BAFF信号通路在各种自身免疫性疾病中的作用机制研究
Shradha Devi Dwivedi,Rashi Shukla,Krishna Yadav et al.
Shradha Devi Dwivedi et al.
iRhom2 is a crucial cofactor involved in upregulation of TNF receptors (TNFRs) and the pro-inflammatory cytokine tumor necrosis factor (TNF-) from the cell surface by ADAM17. Tumor necrosis factor- α converting enzyme (TACE) is another nam...
Three kingdoms and one ceramide to rule them all. A comparison of the structural basis of ceramide-dependent regulation of sphingolipid biosynthesis in animals, plants, and fungi [0.03%]
三个王国和一个神经酰胺统治它们。动物、植物和真菌中依赖神经酰胺调节鞘脂生物合成的结构基础的比较研究
Mohammed H Al Mughram,Glen E Kellogg,Binks W Wattenberg
Mohammed H Al Mughram
Sphingolipids are a diverse class of lipids with essential functions as determinants of membrane physical properties and as intra- and intercellular signaling agents. Disruption of the normal biochemical processes that establish the levels ...
Biological function, topology, and quantification of plasma membrane Ceramide [0.03%]
生物膜甘油二酯的生物学功能，拓扑和定量分析
Daniel Canals,Yusuf A Hannun
Daniel Canals
Over the past 30 years, a growing body of evidence has revealed the regulatory role of the lipid ceramide in various cellular functions. The structural diversity of ceramide, resulting in numerous species, and its distinct distribution with...
Y Wang,M J O Wakelam,V A Bankaitis et al.
Y Wang et al.
Phospholipase D (PLD) hydrolyses phosphatidylcholine (PtdCho) to produce free choline and the critically important lipid signaling molecule phosphatidic acid (PtdOH). Since the initial discovery of PLD activities in plants and bacteria, PLD...
IP8: A quantitatively minor inositol pyrophosphate signaling molecule that punches above its weight [0.03%]
IP8：一种数量上相对较少的肌醇焦磷酸信号分子，作用却不可忽视
Chunfang Gu,Xingyao Li,Guangning Zong et al.
Chunfang Gu et al.
The inositol pyrophosphates (PP-IPs) are specialized members of the wider inositol phosphate signaling family that possess functionally significant diphosphate groups. The PP-IPs exhibit remarkable functionally versatility throughout the eu...
Sonia Raveena Lourdes,Rajendra Gurung,Saveen Giri et al.
Sonia Raveena Lourdes et al.
Phosphoinositides are a minor group of membrane-associated phospholipids that are transiently generated on the cytoplasmic leaflet of many organelle membranes and the plasma membrane. There are seven functionally distinct phosphoinositides,...
Millie Xin Barbernitz,Daniel M Raben
Millie Xin Barbernitz
Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the ATP-dependent conversion of diacylglycerol (DAG) to phosphatidic acid (PtdOH). A common approach to examine the activity of these enzymes relys on a radiometric assay (...
Structural basis for the conserved roles of PI4KA and its regulatory partners and their misregulation in disease [0.03%]
PI4KA及其调控伙伴在保守功能及其疾病中的失调的结构基础
Sushant Suresh,John E Burke
Sushant Suresh
The type III Phosphatidylinositol 4-kinase alpha (PI4KA) is an essential lipid kinase that is a master regulator of phosphoinositide signalling at the plasma membrane (PM). It produces the predominant pool of phosphatidylinositol 4-phosphat...
Miguel Martin-Salgado,Ane Ochoa-Echeverría,Isabel Mérida
Miguel Martin-Salgado
Cancer still represents the second leading cause of death right after cardiovascular diseases. According to the World Health Organization (WHO), cancer provoked around 10 million deaths in 2020, with lung and colon tumors accounting for the...