Mechanistic insight on the role of iRhom2-TNF-α-BAFF signaling pathway in various autoimmune disorders
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iRhom2 is a crucial cofactor involved in upregulation of TNF receptors (TNFRs) and the pro-inflammatory cytokine tumor necrosis factor (TNF-) from the cell surface by ADAM17. Tumor necrosis factor- α converting enzyme (TACE) is another name given to ADAM17. M... ...
