Modulation of skin inflammation by a recombinant Brown spider venom phospholipase D: In silico and in vitro approaches [0.03%]
用于调节皮肤炎症的巴西棕蜘蛛毒液磷脂酶D的体外和计算机模拟研究
Pedro Henrique de Caires Schluga,Marianna Boia-Ferreira,João Lucas Theodoro et al.
Pedro Henrique de Caires Schluga et al.
Envenomation by Loxosceles spiders produces a condition termed loxoscelism, which may manifest in cutaneous and systemic forms. Cutaneous loxoscelism is characterized by intense inflammation and dermonecrosis, driven mainly by phospholipase...
Adrenergic receptor activation shapes circadian clock gene oscillations in HL-1 cardiomyocyte cell line [0.03%]
肾上腺素受体活化影响HL-1心肌细胞系中的昼夜节律基因振荡
Elena Crecca,Martina Pinna,Maria Rita Assenza et al.
Elena Crecca et al.
Circadian rhythms are physiological, biochemical and behavioural processes with a 24-h period molecularly regulated by clock genes. Cardiovascular physiology is subject to circadian variations in heart rate, blood pressure and contractility...
Ecnomotopic expression of olfactory receptors is affected by human apolipoproteins A-IMilano and A-II: evidence from liver microarray analyses [0.03%]
人载脂蛋白A-I米兰和A-II影响嗅觉受体的经动机表达：来自肝脏微阵列分析的证据
Amedeo Amedei,Cinzia Parolini
Amedeo Amedei
Olfactory receptors (ORs) are seven transmembrane domains G protein-coupled receptors (GPCRs) located in the olfactory sensory neurons (OSNs) of the nasal olfactory epithelium. Although OR expression was initially hypothesized to be restric...
Afatinib alters DNA methylation and Paneth-like differentiation markers in Caco-2 cells [0.03%]
阿法替尼可改变Caco-2细胞的DNA甲基化和类似潘氏细胞分化标记物的情况
Ippei Uemura,Natsuko Takahashi-Suzuki,Takashi Satoh
Ippei Uemura
Afatinib is an irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) used to treat EGFR-mutant non-small cell lung cancer. It frequently causes gastrointestinal toxicity that perturbs intestinal homeostasis, a...
An integrative multi-cohort transcriptomic study reveals cell cycle- and adhesion-related hub genes as diagnostic biomarkers for pulmonary arterial hypertension [0.03%]
整合多队列转录组研究揭示细胞周期和粘附相关关键基因可作为肺动脉高压诊断标志物
Jiajia Zou,Guojiao Rao,Xiaomin Hou et al.
Jiajia Zou et al.
Pulmonary arterial hypertension (PAH) is a progressive and fatal vascular disorder for which reliable and non-invasive diagnostic biomarkers remain limited. This study aims to screen and verify the hub genes related to PAH by integrating bi...
Lucio Cocco
Lucio Cocco
Complex role of mTOR signaling pathway in glioblastoma and its stem cells [0.03%]
mTOR信号通路在胶质母细胞瘤及其干细胞中发挥的作用
Austin B Carpenter,Ariel Sacknovitz,Simon Hanft et al.
Austin B Carpenter et al.
Mechanistic target of rapamycin (mTOR: aka mammalian target of rapamycin), a serine threonine kinase, functions by forming two multiprotein complexes designated mTORC1 and mTORC2. This signaling cascade of PI3K/AKT/mTOR is often upregulated...
Inositide-dependent signal transduction in the nucleus: a virtuous path from the laboratory to the clinic [0.03%]
肌醇苷依赖性信号转导在细胞核中的研究：从实验室到临床的探索之路
Alessia De Stefano,James A McCubrey,Pann-Ghill Suh et al.
Alessia De Stefano et al.
The presence of inositol lipids in the nucleus has been shown in the late 1980s and since then a considerable amount of interest has been raised about the role of these molecules in an autonomous nuclear signalling system different from tha...
Harnessing lipid metabolism through diacylglycerol kinases: implications for immune modulation and cancer therapy [0.03%]
二酰甘油激酶调控脂质代谢的机制及其在免疫和肿瘤治疗中的应用前景
Juan José Sánchez-Cabezón,Antonia Ávila-Flores,Isabel Mérida
Juan José Sánchez-Cabezón
Diacylglycerol kinases (DGKs) are key enzymes that integrate lipid metabolism with multiple signaling pathways. DGKs regulate the conversion of diacylglycerol (DAG) into phosphatidic acid (PA), two essential bioactive lipids that promote th...
Plant-derived immunomodulators in cancer: Balancing immune activation and suppression within the tumor microenvironment [0.03%]
植物来源的免疫调节剂在癌症中的作用：肿瘤微环境中平衡免疫激活和抑制
Verena Beier,Michael Wink,Yvonne Samstag
Verena Beier
The immune system is central to the prevention and control of cancer, yet tumors evolve multiple strategies to subvert immune surveillance. Checkpoint inhibitors targeting CTLA-4, PD-1, and PD-L1 have revolutionized oncology by demonstratin...