Afatinib alters DNA methylation and Paneth-like differentiation markers in Caco-2 cells [0.03%]
阿法替尼可改变Caco-2细胞的DNA甲基化和类似潘氏细胞分化标记物的情况
Ippei Uemura,Natsuko Takahashi-Suzuki,Takashi Satoh
Ippei Uemura
Afatinib is an irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) used to treat EGFR-mutant non-small cell lung cancer. It frequently causes gastrointestinal toxicity that perturbs intestinal homeostasis, a...
An integrative multi-cohort transcriptomic study reveals cell cycle- and adhesion-related hub genes as diagnostic biomarkers for pulmonary arterial hypertension [0.03%]
整合多队列转录组研究揭示细胞周期和粘附相关关键基因可作为肺动脉高压诊断标志物
Jiajia Zou,Guojiao Rao,Xiaomin Hou et al.
Jiajia Zou et al.
Pulmonary arterial hypertension (PAH) is a progressive and fatal vascular disorder for which reliable and non-invasive diagnostic biomarkers remain limited. This study aims to screen and verify the hub genes related to PAH by integrating bi...
Lucio Cocco
Lucio Cocco
Complex role of mTOR signaling pathway in glioblastoma and its stem cells [0.03%]
mTOR信号通路在胶质母细胞瘤及其干细胞中发挥的作用
Austin B Carpenter,Ariel Sacknovitz,Simon Hanft et al.
Austin B Carpenter et al.
Mechanistic target of rapamycin (mTOR: aka mammalian target of rapamycin), a serine threonine kinase, functions by forming two multiprotein complexes designated mTORC1 and mTORC2. This signaling cascade of PI3K/AKT/mTOR is often upregulated...
Inositide-dependent signal transduction in the nucleus: a virtuous path from the laboratory to the clinic [0.03%]
肌醇苷依赖性信号转导在细胞核中的研究：从实验室到临床的探索之路
Alessia De Stefano,James A McCubrey,Pann-Ghill Suh et al.
Alessia De Stefano et al.
The presence of inositol lipids in the nucleus has been shown in the late 1980s and since then a considerable amount of interest has been raised about the role of these molecules in an autonomous nuclear signalling system different from tha...
Harnessing lipid metabolism through diacylglycerol kinases: implications for immune modulation and cancer therapy [0.03%]
二酰甘油激酶调控脂质代谢的机制及其在免疫和肿瘤治疗中的应用前景
Juan José Sánchez-Cabezón,Antonia Ávila-Flores,Isabel Mérida
Juan José Sánchez-Cabezón
Diacylglycerol kinases (DGKs) are key enzymes that integrate lipid metabolism with multiple signaling pathways. DGKs regulate the conversion of diacylglycerol (DAG) into phosphatidic acid (PA), two essential bioactive lipids that promote th...
Plant-derived immunomodulators in cancer: Balancing immune activation and suppression within the tumor microenvironment [0.03%]
植物来源的免疫调节剂在癌症中的作用：肿瘤微环境中平衡免疫激活和抑制
Verena Beier,Michael Wink,Yvonne Samstag
Verena Beier
The immune system is central to the prevention and control of cancer, yet tumors evolve multiple strategies to subvert immune surveillance. Checkpoint inhibitors targeting CTLA-4, PD-1, and PD-L1 have revolutionized oncology by demonstratin...
From stress to homeostasis: Mass spectrometry-based insights into the unfolded protein response (UPR) and proteostasis [0.03%]
从压力到稳态：基于质谱技术的未折叠蛋白反应（UPR）和蛋白质稳态研究新进展
Lea A Barny,Lars Plate
Lea A Barny
The unfolded protein response (UPR) is a central regulator of proteostasis, coordinating cellular adaptation to endoplasmic reticulum (ER) stress. It is comprised of three signaling branches: ATF6 (activating transcription factor 6), IRE1 (...
Potential endogenous lipid ligands for the nuclear receptor transcription factor Steroidogenic Factor-1 [0.03%]
类固醇生成因子-1核受体转录因子的潜在内源性配体lipid ligand
Alexis N Campbell,Raymond D Blind
Alexis N Campbell
Nuclear receptors are lipid-regulated transcription factors that respond to the changing metabolic and signaling requirements of animal cells and tissues. Steroidogenic Factor 1 (SF-1, NR5A1) is a nuclear receptor and master regulator of st...
Activity and dynamics of p110α are not differentially modulated by regulatory subunit isoforms [0.03%]
调节亚基不同型不会特异性调节p110α的功能和动态特性
Isobel Barlow-Busch,Emma E Walsh,Hunter G Nyvall et al.
Isobel Barlow-Busch et al.
Class IA phosophoinositide kinases (PI3Ks) are master regulators of growth, metabolism, and immunity. The class IA PI3Ks are a heterodimer composed of a p110 catalytic subunit and one of five possible regulatory subunits (p85α, p85β, p55...