In-depth review of breast cancer and inflammation pre-and post-treatment strategies with conventional and novel Steroid agents [0.03%]
传统和新型甾体药物治疗乳腺癌及其炎性反应的术前术后策略深度评述
Panneerselvam Theivendren,Punitha Narayanasamy,Kumarappan Chidamabaram et al.
Panneerselvam Theivendren et al.
Breast cancer leads to many women's cancer deaths worldwide and inflammation is essential for tumors to develop, advance and spread within the body. High levels of ongoing inflammation within the tumor help cancer cells multiply, encourage ...
Norepinephrine mediates adrenergic receptor transcription and oncogenic gene expression in pancreatic ductal adenocarcinoma [0.03%]
去甲肾上腺素介导胰腺导管腺癌中的肾上腺素受体转录和致癌基因表达
Henry H Brak,Noelle R J Thielman
Henry H Brak
Adrenergic stimulation of β2 receptors has shown to increase pancreatic ductal adenocarcinoma (PDAC) proliferation and migration in an in vitro setting; however, the role of α1 receptors in these adrenergic signaling pathways is unclear. ...
Lysophosphatidic acid (LPA) receptor signaling modulates cellular functions of colon cancer cells under cobalt chloride-induced hypoxic conditions [0.03%]
缺氧条件下胶质瘤细胞溶血磷脂酸受体信号通路对胶质瘤细胞功能的调节作用研究
Mao Yamamoto,Miwa Takai,Narumi Yashiro et al.
Mao Yamamoto et al.
In the tumor microenvironment (TME), hypoxia is critical in promoting tumor invasiveness and progression. Cobalt chloride (CoCl2) mimics hypoxia by inducing comparable cellular responses. Lysophosphatidic acid (LPA) receptors (LPA1 to LPA6)...
Solid pancancer analysis reveals immune and hematopoietic stem cell and DNA damage repair signatures to distinguish different cancer subtypes [0.03%]
全面的肿瘤分析揭示了免疫和造血干细胞以及DNA损伤修复特征可区分不同癌症亚型
Nayila Abulimiti,Rongzhuo Long,Yin He et al.
Nayila Abulimiti et al.
Purpose: Immunity, stemness, and DNA damage repair (DDR) are crucial for cancer development and therapy resistance. With advancements in multiomics technology, the exploration of cancers related to immunity, stemness, and...
Lipin phosphatidic acid phosphatases: Structure, function, regulation, and disease association [0.03%]
脂磷脂酶：结构、功能、调控及与疾病的关系
Franceine S Welcome,Taisha C M Elizaire,Michael V Airola
Franceine S Welcome
Lipids play essential roles as structural barriers in cell membranes, long-term energy storage, and as signaling molecules. One class of enzymes involved in lipid synthesis are lipins. Lipins are magnesium-dependent phosphatidic acid phosph...
TP53 gene status can promote sensitivity and resistance to chemotherapeutic drugs and small molecule signal transduction inhibitors [0.03%]
TP53基因状态可以促进化疗药物和小分子信号转导抑制剂的敏感性和耐药性
James A McCubrey,Matilde Y Follo,Stefano Ratti et al.
James A McCubrey et al.
TP53 is normally a tumor suppressor. However, it is mutated in at least 50% of human cancers. Usually, we assume that mutation of the TP53 is associated with loss of sensitivity to various drugs as in most cases wild type (WT) TP53 activity...
Insights into phosphatidic acid phosphatase and its potential role as a therapeutic target [0.03%]
磷脂酸磷酸酶研究进展及其作为药物靶点的潜力分析
George M Carman,Geordan J Stukey,Ruta Jog et al.
George M Carman et al.
Phosphatidic acid phosphatase, a conserved eukaryotic enzyme that catalyzes the Mg2+-dependent dephosphorylation of phosphatidic acid to produce diacylglycerol, has emerged as a vital regulator of lipid homeostasis. By controlling the balan...
Molecular basis of JAK kinase regulation guiding therapeutic approaches: Evaluating the JAK3 pseudokinase domain as a drug target [0.03%]
janus激酶的调节机制指导治疗方法：评估jak3假酶结构域作为药物靶点的可能性
Anniina Virtanen,Vivian Kettunen,Kirsikka Musta et al.
Anniina Virtanen et al.
Janus kinases (JAK1-3, TYK2) are critical mediators of cytokine signaling and their role in hematological and inflammatory and autoimmune diseases has sparked widespread interest in their therapeutic targeting. JAKs have unique tandem kinas...
Danielle M Smith,Joseph Choi,Michael J Wolfgang
Danielle M Smith
Mitochondrial long chain fatty acid β-oxidation is a critical central carbon catabolic process. The importance of fatty acid oxidation is made evident by the life-threatening disease associated with diverse inborn errors in the pathway. Wh...
Signaling pathways and bone marrow microenvironment in myelodysplastic neoplasms [0.03%]
骨髓增生异常肿瘤的信号转导通路和骨髓微环境
Eleonora Ceneri,Alessia De Stefano,Irene Casalin et al.
Eleonora Ceneri et al.
Key signaling pathways within the Bone Marrow Microenvironment (BMM), such as Notch, Phosphoinositide-Specific Phospholipase C (PI-PLCs), Transforming Growth Factor β (TGF-β), and Nuclear Factor Kappa B (NF-κB), play a vital role in the ...