Inositide-dependent signal transduction in the nucleus: a virtuous path from the laboratory to the clinic [0.03%]
肌醇苷依赖性信号转导在细胞核中的研究：从实验室到临床的探索之路
Alessia De Stefano,James A McCubrey,Pann-Ghill Suh et al.
Alessia De Stefano et al.
The presence of inositol lipids in the nucleus has been shown in the late 1980s and since then a considerable amount of interest has been raised about the role of these molecules in an autonomous nuclear signalling system different from tha...
Harnessing lipid metabolism through diacylglycerol kinases: implications for immune modulation and cancer therapy [0.03%]
二酰甘油激酶调控脂质代谢的机制及其在免疫和肿瘤治疗中的应用前景
Juan José Sánchez-Cabezón,Antonia Ávila-Flores,Isabel Mérida
Juan José Sánchez-Cabezón
Diacylglycerol kinases (DGKs) are key enzymes that integrate lipid metabolism with multiple signaling pathways. DGKs regulate the conversion of diacylglycerol (DAG) into phosphatidic acid (PA), two essential bioactive lipids that promote th...
Plant-derived immunomodulators in cancer: Balancing immune activation and suppression within the tumor microenvironment [0.03%]
植物来源的免疫调节剂在癌症中的作用：肿瘤微环境中平衡免疫激活和抑制
Verena Beier,Michael Wink,Yvonne Samstag
Verena Beier
The immune system is central to the prevention and control of cancer, yet tumors evolve multiple strategies to subvert immune surveillance. Checkpoint inhibitors targeting CTLA-4, PD-1, and PD-L1 have revolutionized oncology by demonstratin...
From stress to homeostasis: Mass spectrometry-based insights into the unfolded protein response (UPR) and proteostasis [0.03%]
从压力到稳态：基于质谱技术的未折叠蛋白反应（UPR）和蛋白质稳态研究新进展
Lea A Barny,Lars Plate
Lea A Barny
The unfolded protein response (UPR) is a central regulator of proteostasis, coordinating cellular adaptation to endoplasmic reticulum (ER) stress. It is comprised of three signaling branches: ATF6 (activating transcription factor 6), IRE1 (...
Potential endogenous lipid ligands for the nuclear receptor transcription factor Steroidogenic Factor-1 [0.03%]
类固醇生成因子-1核受体转录因子的潜在内源性配体lipid ligand
Alexis N Campbell,Raymond D Blind
Alexis N Campbell
Nuclear receptors are lipid-regulated transcription factors that respond to the changing metabolic and signaling requirements of animal cells and tissues. Steroidogenic Factor 1 (SF-1, NR5A1) is a nuclear receptor and master regulator of st...
Activity and dynamics of p110α are not differentially modulated by regulatory subunit isoforms [0.03%]
调节亚基不同型不会特异性调节p110α的功能和动态特性
Isobel Barlow-Busch,Emma E Walsh,Hunter G Nyvall et al.
Isobel Barlow-Busch et al.
Class IA phosophoinositide kinases (PI3Ks) are master regulators of growth, metabolism, and immunity. The class IA PI3Ks are a heterodimer composed of a p110 catalytic subunit and one of five possible regulatory subunits (p85α, p85β, p55...
Pharmacological SHIP2 blockade enhances sensitivity to standard and targeted cancer therapies [0.03%]
药理学SHIP2阻断可增强对标准及靶向癌症治疗的敏感性
Nadia Gillet,Cyril Bodart,Benjamin Beck
Nadia Gillet
Esophageal squamous cell carcinoma (eSCC) is an aggressive malignancy with poor prognosis and limited therapeutic options. The phosphoinositide 3-kinase (PI3K)/AKT pathway is frequently activated in eSCC, but clinical use of PI3K or AKT inh...
The AP-4 accessory protein tepsin exhibits multivalent binding to LC3B [0.03%]
AP-4 附属蛋白 tepsin 可与 LC3B 多价结合
Cameron I Cohen,Amy K Kendall,Natalie S Wallace et al.
Cameron I Cohen et al.
Tepsin is an accessory protein in Adaptor Protein 4 (AP-4) coated vesicles responsible for trafficking cargo from the trans-Golgi network (TGN). AP-4 vesicles recognize and sort multiple cargoes including ATG9A, a lipid scramblase essential...
PKCα as a signaling gatekeeper upstream of mTORC1 in mEGFR NSCLC [0.03%]
mEGFR NSCLC中PKCα作为mTORC1上游的信号守门员
Mojtaba Sadeghi,Sam B Chiappone,Mohamed F Salama et al.
Mojtaba Sadeghi et al.
Despite decades of research since phorbol esters first linked protein kinase C (PKC) to tumor promotion, the biological role of this family of kinases in cancer has remained ambiguous because of isozyme-specific functions and tissue-type-de...
Phosphatidic acid at the crossroads of membrane dynamics: from molecular specificity to synthetic innovation [0.03%]
磷脂酸在膜动态的十字路口：从中分子特异性到合成创新
Alexander Wolf,Emeline Tanguy,Stéphane Gasman et al.
Alexander Wolf et al.
Phosphatidic acid (PA) has emerged as a central regulator of membrane dynamics, vesicle trafficking, exocytosis, and intracellular signaling. Building on recent advances, including subspecies-specific functions of PA in neuroendocrine exocy...