Induction of lysophosphatidic acid (LPA) receptor-mediated signaling regulates cell motility and survival to anticancer drugs in cancer cells treated with hydrogen peroxide [0.03%]
过氧化氢处理的癌细胞中lysophosphatidic acid (LPA)受体介导信号的诱导调节细胞迁移和抗癌药物存活率
Miwa Takai,Miyu Takamoto,Yuka Amano et al.
Miwa Takai et al.
Hydrogen peroxide (H2O2) is one of reactive oxygen species (ROS) and promotes malignant properties of cancer cells. Lysophosphatidic acid (LPA) signaling via LPA receptor (LPA1 to LPA6) regulates a variety of cellular functions, such as cel...
A possible role for G-quadruplexes formation and DNA methylation at IMOOD gene promoter in Obsessive Compulsive Disorder [0.03%]
IMOOD基因启动子区G-四链体形成和DNA甲基化在强迫症中的作用研究
Annalaura Sabatucci,Antonio Girella,Martina Di Bartolomeo et al.
Annalaura Sabatucci et al.
Obsessive Compulsive Disorder (OCD) is a mental health condition still classified and diagnosed with subjective interview-based assessments and which molecular clues have not completely been elucidated. We have recently identified a new reg...
A motif in the 5'untranslated region of messenger RNAs regulates protein synthesis in a S6 kinase-dependent manner [0.03%]
一种位于信使RNA的5'非翻译区内的基序以S6激酶依赖的方式调节蛋白质合成
Hyun-Chul Shin,Yury A Bochkov,Kangsan Kim et al.
Hyun-Chul Shin et al.
The 5' untranslated regions (UTRs) in messenger RNAs (mRNAs) play an important role in the regulation of protein synthesis. We had previously identified a group of mRNAs that includes human semaphorin 7A (SEMA7A) whose translation is upregu...
Circulating ACE2 level and zinc/albumin ratio as potential biomarkers for a precision medicine approach to COVID-19 [0.03%]
循环ACE2水平和锌/白蛋白比率作为针对COVID-19的精准医学方法的潜在生物标志物
Serena Benedetti,Davide Sisti,Daniela Vandini et al.
Serena Benedetti et al.
Highly mutable influenza is successfully countered based on individual susceptibility and similar precision-like medicine approach should be effective against SARS-COV-2. Among predictive markers to bring precision medicine to COVID-19, cir...
Improved efficacy of quizartinib in combination therapy with PI3K inhibition in primary FLT3-ITD AML cells [0.03%]
用于FLT3-ITD阳性急性髓系白血病原代细胞的Quizartinib与PI3K抑制剂联合治疗的增效作用
Salihanur Darici,Heather G Jørgensen,Xu Huang et al.
Salihanur Darici et al.
Acute myeloid leukemia is a heterogeneous hematopoietic malignancy, characterized by uncontrolled clonal proliferation of abnormal myeloid progenitor cells, with poor outcomes. The internal tandem duplication (ITD) mutation of the Fms-like ...
Targeted pharmacologic inhibition of S-phase kinase-associated protein 2 (SKP2) mediated cell cycle regulation in lung and other RB-Related cancers: A brief review of current status and future prospects [0.03%]
针对S期激酶相关蛋白2（SKP2）介导的细胞周期调控的靶向药理抑制在肺癌和其它RB相关肿瘤中的作用：现状及未来前景简述
Abul H Elahi,Cordelia S Morales,Xiaoliang L Xu et al.
Abul H Elahi et al.
Small cell lung cancer (SCLC) often exhibits Rb deficiency, TRβ and p130 deletion, and SKP2 amplification, suggesting TRβ inactivation and SKP2 activation. It is reported that SKP2 targeted therapy is effective in some cancers in vitro an...
A potential requirement for Smad3 phosphorylation in Notch-mediated EMT in colon cancer [0.03%]
结肠癌中Notch诱导的上皮间质转化可能需要Smad3磷酸化
Alexander G Clark,Fred E Bertrand,George Sigounas
Alexander G Clark
Colorectal cancer (CRC) remains a challenging disease to treat due to several factors including stemness and epithelial to mesenchymal transition (EMT). Dysfunctional signaling pathways such as Notch and TGF-β contribute to these phenomena...
Preclinical models of non-alcoholic steatohepatitis leading to hepatocellular carcinoma [0.03%]
非酒精性脂肪肝病肝细胞癌小鼠模型
Christopher D Green,Sarah Spiegel
Christopher D Green
Hepatocellular carcinoma (HCC) is the third leading cause of cancer related deaths worldwide and its incidence is increasing due to endemic obesity and the growing burden of non-alcoholic steatohepatitis (NASH) associated liver cancer. Alth...
Alessia De Stefano,Maria Vittoria Marvi,Antonietta Fazio et al.
Alessia De Stefano et al.
Aberrant signaling pathways regulating proliferation and differentiation of hematopoietic stem cells (HSCs) can contribute to disease pathogenesis and neoplastic growth. Phosphoinositides (PIs) are inositol phospholipids that are implicated...
Defining the role of mTOR pathway in the regulation of stem cells of glioblastoma [0.03%]
mTOR通路在胶质母细胞瘤干细胞调控中的作用定义
Meena Jhanwar-Uniyal,Olivia Gellerson,Julie Bree et al.
Meena Jhanwar-Uniyal et al.
The mechanistic target of rapamycin (mTOR), a serine/threonine kinase, functions by forming two multiprotein complexes termed mTORC1 and mTORC2. Glioblastoma (GBM) is a uniformly fatal brain tumor that remains incurable partly due to the ex...