Circulating ACE2 level and zinc/albumin ratio as potential biomarkers for a precision medicine approach to COVID-19 [0.03%]
循环ACE2水平和锌/白蛋白比率作为针对COVID-19的精准医学方法的潜在生物标志物
Serena Benedetti,Davide Sisti,Daniela Vandini et al.
Serena Benedetti et al.
Highly mutable influenza is successfully countered based on individual susceptibility and similar precision-like medicine approach should be effective against SARS-COV-2. Among predictive markers to bring precision medicine to COVID-19, cir...
Improved efficacy of quizartinib in combination therapy with PI3K inhibition in primary FLT3-ITD AML cells [0.03%]
用于FLT3-ITD阳性急性髓系白血病原代细胞的Quizartinib与PI3K抑制剂联合治疗的增效作用
Salihanur Darici,Heather G Jørgensen,Xu Huang et al.
Salihanur Darici et al.
Acute myeloid leukemia is a heterogeneous hematopoietic malignancy, characterized by uncontrolled clonal proliferation of abnormal myeloid progenitor cells, with poor outcomes. The internal tandem duplication (ITD) mutation of the Fms-like ...
Targeted pharmacologic inhibition of S-phase kinase-associated protein 2 (SKP2) mediated cell cycle regulation in lung and other RB-Related cancers: A brief review of current status and future prospects [0.03%]
针对S期激酶相关蛋白2（SKP2）介导的细胞周期调控的靶向药理抑制在肺癌和其它RB相关肿瘤中的作用：现状及未来前景简述
Abul H Elahi,Cordelia S Morales,Xiaoliang L Xu et al.
Abul H Elahi et al.
Small cell lung cancer (SCLC) often exhibits Rb deficiency, TRβ and p130 deletion, and SKP2 amplification, suggesting TRβ inactivation and SKP2 activation. It is reported that SKP2 targeted therapy is effective in some cancers in vitro an...
A potential requirement for Smad3 phosphorylation in Notch-mediated EMT in colon cancer [0.03%]
结肠癌中Notch诱导的上皮间质转化可能需要Smad3磷酸化
Alexander G Clark,Fred E Bertrand,George Sigounas
Alexander G Clark
Colorectal cancer (CRC) remains a challenging disease to treat due to several factors including stemness and epithelial to mesenchymal transition (EMT). Dysfunctional signaling pathways such as Notch and TGF-β contribute to these phenomena...
Preclinical models of non-alcoholic steatohepatitis leading to hepatocellular carcinoma [0.03%]
非酒精性脂肪肝病肝细胞癌小鼠模型
Christopher D Green,Sarah Spiegel
Christopher D Green
Hepatocellular carcinoma (HCC) is the third leading cause of cancer related deaths worldwide and its incidence is increasing due to endemic obesity and the growing burden of non-alcoholic steatohepatitis (NASH) associated liver cancer. Alth...
Alessia De Stefano,Maria Vittoria Marvi,Antonietta Fazio et al.
Alessia De Stefano et al.
Aberrant signaling pathways regulating proliferation and differentiation of hematopoietic stem cells (HSCs) can contribute to disease pathogenesis and neoplastic growth. Phosphoinositides (PIs) are inositol phospholipids that are implicated...
Defining the role of mTOR pathway in the regulation of stem cells of glioblastoma [0.03%]
mTOR通路在胶质母细胞瘤干细胞调控中的作用定义
Meena Jhanwar-Uniyal,Olivia Gellerson,Julie Bree et al.
Meena Jhanwar-Uniyal et al.
The mechanistic target of rapamycin (mTOR), a serine/threonine kinase, functions by forming two multiprotein complexes termed mTORC1 and mTORC2. Glioblastoma (GBM) is a uniformly fatal brain tumor that remains incurable partly due to the ex...
AP-4 loss in CRISPR-edited zebrafish affects early embryo development [0.03%]
CRISPR编辑的斑马鱼中AP-4损失影响早期胚胎发育
Olivia G Pembridge,Natalie S Wallace,Thomas P Clements et al.
Olivia G Pembridge et al.
Mutations in the heterotetrametric adaptor protein 4 (AP-4; ε/β4/μ4/σ4 subunits) membrane trafficking coat complex lead to complex neurological disorders characterized by spastic paraplegia, microcephaly, and intellectual disabilities. ...
Signaling pathways and regulation of gene expression in hematopoietic cells [0.03%]
造血细胞中的信号转导通路及基因表达调控
Daniel Bogush,Joseph Schramm,Yali Ding et al.
Daniel Bogush et al.
Cellular functions are regulated by signal transduction pathway networks consisting of protein-modifying enzymes that control the activity of many downstream proteins. Protein kinases and phosphatases regulate gene expression by reversible ...
Lucio Cocco
Lucio Cocco