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Improved efficacy of quizartinib in combination therapy with PI3K inhibition in primary FLT3-ITD AML cells

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Acute myeloid leukemia is a heterogeneous hematopoietic malignancy, characterized by uncontrolled clonal proliferation of abnormal myeloid progenitor cells, with poor outcomes. The internal tandem duplication (ITD) mutation of the Fms-like receptor tyrosine ki... ...