The C-terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice [0.03%]
KIF26B羧端对于小鼠后肾胚基细胞凝聚及肾脏形成不可或缺
Yuta Yamamura,Kengo Furuichi,Hiromitsu Akamatsu et al.
Yuta Yamamura et al.
Loss of Kif26b function causes renal agenesis or hypoplasia in mice, and a KIF26B mutation resulting in deletion of the C-terminal region has been identified in a human patient with a congenital kidney disorder. However, the role of this re...
Aquaporin-3 and aquaporin-5 impact the development of pancreatic ductal adenocarcinoma spheroids [0.03%]
Aquaporin-3和Aquaporin-5影响胰腺导管腺癌类器官的发育
Catarina Pimpão,Diogo M Engrácia,Graça Soveral et al.
Catarina Pimpão et al.
Pancreatic ductal adenocarcinoma (PDAC) is the seventh leading cause of cancer-related mortality, with poor survival due to late diagnosis and ineffective therapies. Aquaporin-3 (AQP3) and AQP5 are transmembrane proteins overexpressed in PD...
Acute caffeine treatment protects the developing retina from ischemia-induced cell death [0.03%]
急性咖啡因治疗可保护缺血引起的视网膜细胞死亡
Amanda Alves Nascimento,Danniel Pereira-Figueiredo,Gabriella Grossi de Lima Dias et al.
Amanda Alves Nascimento et al.
Ischemic damage to the retina during development can lead to irreversible neuronal loss, driven in part by excitotoxic mechanisms and energy deprivation. While two-day caffeine exposure has previously been shown to confer neuroprotection in...
Maria Tomkova,Andrej Mirossay,Erik Sedlak
Maria Tomkova
Directed evolution has become a central methodology for engineering proteins with improved or entirely new functions, enabling applications across biotechnology, medicine, and synthetic chemistry. By iteratively coupling genetic diversifica...
Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection [0.03%]
新的细胞因子CC亚家族和CXC亚家族趋化因子及其受体在结核杆菌感染中的作用机制及研究进展
Xuying Yin,Dangsheng Xiao,Jiezuan Yang
Xuying Yin
Chemokines and their cognate receptors are central orchestrators of the immune response to Mycobacterium tuberculosis (Mtb) infection. While their overall significance in tuberculosis (TB) is well-established, this review synthesizes recent...
The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long-standing annotation error [0.03%]
解螺旋体尼科酸酶结构解析纠正了一个长期存在的错误注释问题
Kalvis Brangulis
Kalvis Brangulis
Nicotinamidases (PncA) catalyze the hydrolysis of nicotinamide to nicotinic acid, a key step in NAD+ salvage pathways. In the Lyme disease spirochete Borrelia burgdorferi, the plasmid-encoded gene bbe22 encodes a PncA enzyme that is essenti...
Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long-chain fatty acid accumulation after myocardial ischemia-reperfusion in mice [0.03%]
环状azapetide CD36配体通过减轻心肌缺血再灌注后的心脏损伤和长链脂肪酸蓄积发挥保护作用
Jade Gauvin,Naghme Radmannia,David N Huynh et al.
Jade Gauvin et al.
Ischemic heart disease remains a leading global cause of death. We investigated the cardioprotective effects of the selective cluster of differentiation-36 receptor (CD36) modulator azapeptide MPE-298 in a mouse model of myocardial ischemia...
Dimitris Kletsas
Dimitris Kletsas
Cellular senescence, a state of stable cell-cycle arrest accompanied by profound metabolic and secretory changes, has emerged as a central hallmark of aging and a key contributor to age-associated diseases. Despite the great progress in und...
UiO-66 metal-organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy [0.03%]
用于生物医学的UiO-66金属有机框架：从结构可调性到生物成像，光诊断和光动力癌症治疗
Veronika Huntošová,Grigorii Rakhalskii,Miroslav Almáši
Veronika Huntošová
UiO-66-type zirconium metal-organic frameworks (MOFs) have emerged as robust and highly tunable nanoplatforms for biomedical applications owing to their permanent porosity, exceptional chemical stability, and versatile functionalization pat...
Optimizing photoactivation of PA-mCherry for optical pooled CRISPR screens [0.03%]
优化光学组合CRISPR筛选中的PA-mCherry光活化性能
Sravasti Mukherjee,Giulia Zanetti,Bram van den Broek et al.
Sravasti Mukherjee et al.
Optical pooled CRISPR screens have become an attractive tool for the rapid identification of genes involved in biological processes. In such screens, mixed populations of cells, each with a single gene knocked out, are screened by microscop...