Yeast Gcn2 retains activity following humanization of its auto-phosphorylation region [0.03%]
人源化其自磷酸化区域后酵母Gcn2仍保持活性
Reuben A Anderson,Anja H Schiemann,Evelyn Sattlegger
Reuben A Anderson
The protein kinase Gcn2 is a conserved component of a eukaryotic signaling pathway best known for helping cells cope with amino acid shortage. Upon starvation, Gcn2 auto-phosphorylates and then phosphorylates eIF2α, triggering widespread c...
Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish [0.03%]
黏菌素在鱼类中进化上保守但在斑马鱼发育和抵抗肺炎链球菌感染中可有可无
Anni K Saralahti,Markus J T Ojanen,Mataleena Parikka et al.
Anni K Saralahti et al.
Biotin is a vital cofactor in cellular carboxylation reactions and avidins are biotin-binding proteins that are produced by bacteria and fungi but also by egg-laying vertebrates, including avian species and zebrafish (Danio rerio). Although...
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols [0.03%]
基于计算和体外实验探索酪氨酸酶生物催化生产儿茶酚类化合物的能力
James Britton,Fang Zhao,Reeta Davis et al.
James Britton et al.
Tyrosinases are binuclear copper enzymes widely used for the hydroxylation of phenolic compounds, yet most exhibit higher activity towards diphenols than monophenols, limiting their utility for catechol synthesis. However, a tyrosinase from...
Adenosine triphosphate as a modulator of protein interactions and stability [0.03%]
腺苷三磷酸作为蛋白质相互作用和稳定性的调节因子
Shuyuan Tan,Robin Curtis
Shuyuan Tan
Beyond its classical role as the cellular energy currency, adenosine triphosphate (ATP) can directly modulate protein stability, solubility and self-assembly through weak nonspecific interactions. Here, we summarise the current experimental...
Veronica Morea,Francesco Angelucci,Federica Arnesano et al.
Veronica Morea et al.
Heterotropic regulation of protein function is crucial for such diverse cellular events as transcription, signal transduction, enzymatic activity, transport and many others. It is achieved via ligand-induced changes in protein structure and...
Syamantak Ghosh,Kamalika Mukherjee,Suvendra N Bhattacharyya
Syamantak Ghosh
The import of miRNA across the endosomal membrane is an essential prerequisite for the loading of miRNAs into the endosomal lumen. These miRNAs are then incorporated into mature multivesicular bodies (MVBs), which then fuse with the plasma ...
Dual native G-quadruplex folding is associated with chromatin looping at the MYC locus [0.03%]
着丝粒G-四链体的双天然折叠与MYC位点染色质环形成有关
Dieila Giomo de Lima,Gustavo Narvaes Guimarães,Emilyane de Oliveira Santana Amaral et al.
Dieila Giomo de Lima et al.
DNA can adopt noncanonical four-stranded structures known as G-quadruplexes (G4s), which are enriched at regulatory regions and implicated in transcriptional control. However, the process by which native G4 folding contributes to enhancer-p...
Identification of (20R)-protopanaxadiol from Panax ginseng as a novel anti-SARS-CoV-2 compound [0.03%]
从人参中鉴定出（20R）-原人参二醇可作为新型抗SARS-CoV-2化合物
Midori Takeda,Natsue Maezono,Rina Uchikoshi et al.
Midori Takeda et al.
COVID-19 remains a global health concern, yet current antivirals are restricted to high-risk patients and face issues of resistance. To establish a safer evaluation system, we constructed a noninfectious SARS-CoV-2 replicon using a BAC vect...
De novo synthesis of short-chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys [0.03%]
褐缘拟斑潜叶虫分泌的短链脂肪醛和轻质碳氢化合物的从头合成
Haruna Fujimori,Koji Noge
Haruna Fujimori
Most heteropterans release pungent or characteristic secretions that help protect them against predators and pathogens. However, the biosynthesis of these secretions is poorly understood. The secretion of the brown marmorated stink bug Haly...