The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long-standing annotation error
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Nicotinamidases (PncA) catalyze the hydrolysis of nicotinamide to nicotinic acid, a key step in NAD+ salvage pathways. In the Lyme disease spirochete Borrelia burgdorferi, the plasmid-encoded gene bbe22 encodes a PncA enzyme that is essential for survival in b... ...
