Imaging poly(ADP-ribose) polymerase-1 (PARP1) in vivo with 18F-labeled brain penetrant positron emission tomography (PET) ligand [0.03%]
一种可穿透血脑屏障的放射性氟标记化合物用于正电子发射断层显像(PET)成像活体内多聚(ADP核糖)聚合酶-1(PARP1)
Xin Zhou,Jiahui Chen,Jimmy S Patel et al.
Xin Zhou et al.
Poly(ADP-ribose) polymerase 1 (PARP1) is a multifunctional protein involved in diverse cellular functions, notably DNA damage repair. Pharmacological inhibition of PARP1 has therapeutic benefits for various pathologies. Despite the increase...
PROTAC-loaded nanocapsules degrading BRD4 for radio-chemotherapy sensitization in glioblastoma [0.03%]
载有PROTAC的纳米囊泡通过降解BRD4增强胶质母细胞瘤放化疗敏感性
Yun Guo,Mingzhu Fang,Shilin Zhang et al.
Yun Guo et al.
Glioblastoma (GBM) is a highly aggressive primary brain tumor characterized by poor prognosis. Conventional chemo-radiotherapy demonstrates limited therapeutic efficacy and is often accompanied by significant side effects, largely due to fa...
Divergent activation patterns of BRS3 revealed by two Chinese herb-derived agonists [0.03%]
两种中药衍生物激动剂诱导BRS3的激活模式差异性分析
Jie Li,Changyao Li,Qingtong Zhou et al.
Jie Li et al.
Bombesin receptor subtype-3 (BRS3) is an orphan G protein-coupled receptor (GPCR) that plays critical roles in energy homeostasis, glucose metabolism, and insulin secretion. Recent structural studies have elucidated BRS3 signaling mechanism...
Sergio Barrios,Elisa Serafini,Ludovica La Posta et al.
Sergio Barrios et al.
Radium-223 (223Ra) is a bone-seeking, alpha-particle-emitting radionuclide that is approved for the treatment of patients with metastatic prostate cancer and is currently being tested in clinical trials for primary and metastatic cancers to...
VIRMA-mediated SHQ1 m6A modification enhances liver regeneration through an HNRNPA2B1-dependent mechanism [0.03%]
VIRMA介导的SHQ1m6A修饰通过HNRNPA2B1依赖机制促进肝再生
Hao Chen,Haichuan Wang,Jiwei Huang et al.
Hao Chen et al.
N6-Methyladenosine (m6A) modification is a crucial post-transcriptional regulatory mechanism and the most abundant and highly conserved RNA epigenetic modification in eukaryotes. Previous studies have indicated the involvement of m6A modifi...
Cerium single-atom catalysts-armed Lactobacillus reuteri for multipronged anti-inflammatory/anti-fibrotic therapy of inflammatory bowel disease [0.03%]
用于炎症性肠病的多功能抗炎/抗纤维化治疗的Ce单原子催化剂武装Lactobacillus reuteri
Yinying Pu,Shaorong Huang,Shuang Gao et al.
Yinying Pu et al.
Simultaneous management of intestinal mucosal barrier dysfunction and gut microbiota dysregulation represents a significant challenge in the treatment of inflammatory bowel disease (IBD). Herein, we report a novel system that integrates mul...
Discovery of orally active and serine-targeting covalent inhibitors against hCES2A for ameliorating irinotecan-triggered gut toxicity [0.03%]
用于改善依立替康引发的肠道毒性的口服活性和针对丝氨酸的共价抑制剂hCES2A的发现
Ya Zhang,Yufan Fan,Yunqing Song et al.
Ya Zhang et al.
Human carboxylesterase 2A (hCES2A) plays pivotal roles in prodrug activation and hydrolytic metabolism of ester-bearing chemicals. Targeted inhibition of intestinal hCES2A represents a feasible strategy to mitigate irinotecan-triggered gut ...
Anti-CD24 antibody-nitric oxide donor conjugates bearing a self-bioorthogonal cleavable linker [0.03%]
携带自生物正交可裂解连接物的抗CD24抗体-供氮氧化物衍生物缀合物
Jianbing Wu,Tianyue Cheng,Jiajun Xie et al.
Jianbing Wu et al.
Triple-negative breast cancer (TNBC) is a highly aggressive malignancy predominantly managed via chemotherapy. Our clinical sample analysis revealed a significant correlation between elevated CD24 expression in TNBC tumor cells and patient ...
Self-illuminating liposome-derived in situ triggerable photodynamic therapy combining radionuclide therapy for synergistic treatment of lung cancer [0.03%]
自发光脂质体结合放射核素协同治疗肺癌的在体触发光动力疗法
Chunsen Yuan,Taotao Jin,Hangke Lei et al.
Chunsen Yuan et al.
The persistent high prevalence and poor survival outcomes of lung cancer underscore the urgent need for innovative therapeutic modalities. Here, we present a novel multifunctional delivery platform for the synergistic treatment of lung mali...
Small-sized twin-nanoparticles normalize tumor vasculature to enhance tumor accumulation and penetration for potent eradication of cancer stem-like cells [0.03%]
小型双纳米粒子用于肿瘤血管正常化以增强肿瘤积聚和渗透从而有效根除癌干细胞样细胞
Changshun Zhao,Wei Wang,Zhengchun Huang et al.
Changshun Zhao et al.
Cancer stem cells (CSCs) are proposed to account for the progression, metastasis, and recurrence of diverse malignancies. However, the disorganized vasculars in tumors hinder the accumulation and penetration of nanomedicines, posing a chall...