Reprogramming the spleen-brain axis: Splenic monocyte/macrophage-mediated nanotherapy for ischemic stroke [0.03%]
脾-脑轴的重编程：缺血性卒中的脾脏单核细胞/巨噬细胞介导的纳米治疗
Xiaodi Shi,Rabeya Jafrin Mow,Chunhua Yang
Xiaodi Shi
Attenuating AAV-triggered innate immunity in the adult mouse nervous system via cGAS-STING pathway inhibition [0.03%]
通过抑制cGAS-STING途径减轻AAV触发的成人鼠神经系统的先天免疫反应
Yaowei Guo,Jiehao Huang,Yuqi Zhang et al.
Yaowei Guo et al.
While adeno-associated virus (AAV)-mediated gene delivery has emerged as a promising therapeutic modality for neurological disorders, dose-dependent immune responses remain a critical barrier to clinical translation. Here we reveal the cycl...
Target degradation of CASPASE-1 for alleviation of inflammation in sepsis via optogenetically engineered extracellular vesicles [0.03%]
通过光遗传工程外泌体靶向降解CASPASE-1缓解脓毒症炎症
Yuting Du,Dan Xiao,Heng Li et al.
Yuting Du et al.
Sepsis is a comprehensive ailment of systemic inflammatory response syndrome arising from infection. Activation of CASPASE-1 plays a central role in initiating the inflammatory cascade during sepsis. Herein, we construct optogenetically eng...
Accurate and task-agnostic modeling of enzymatic reactions through multimodal relational learning [0.03%]
通过多模态关系学习精确而任务不可知地建立酶促反应模型
Yuansheng Huang,Lanqing Li,Wenjia Qian et al.
Yuansheng Huang et al.
Enzymatic reactions play an emerging role in a broad spectrum of scientific and industrial applications. The inherent complexity of enzymes, such as their substrate specificity, conformational flexibility, and the vast diversity of reaction...
Computation-driven discovery of novel chromone derivatives for the treatment of triple-negative breast cancer via mTOR-targeted inhibition and triggering antitumor immunity [0.03%]
基于计算的mTOR靶向抑制和触发抗肿瘤免疫治疗三阴性乳腺癌的新香豆素衍生物的研究与发现
Ji-Quan Zhang,Nana Zhang,Yunsheng Ran et al.
Ji-Quan Zhang et al.
Triple-negative breast cancer (TNBC) is a highly aggressive and heterogeneous subtype of breast cancer characterized by early metastasis, poor prognosis, and high recurrence rates. Targeting dysregulated PI3K/Akt/mTOR signaling and triggeri...
Revolutionizing drug discovery from natural products: The roles of artificial intelligence and multi-omics in accelerating innovation [0.03%]
人工智能和多组学在加速创新中的作用：革命性地发现天然药物
Boyang Wang,Qingyuan Liu,Weibo Zhao et al.
Boyang Wang et al.
Natural products and their derivatives have long been crucial in drug therapy, especially in traditional medicine. However, challenges in screening, isolation, characterization, and optimization have slowed their development in the pharmace...
Cryptic pockets in proteins: Harnessing conformational dynamics for rational drug design [0.03%]
蛋白质中的隐秘口袋：利用构象动力学进行理性药物设计
Feiyue Ma,Shuo Wang,Chunkyu Ko et al.
Feiyue Ma et al.
PYGL-driven glycogenolysis impairs microglial autophagic flux via SNAP29 O-GlcNAcylation in Alzheimer's disease [0.03%]
由PYGL驱动的糖原分解通过SNAP29 O-GlcNAc酰化损害阿尔茨海默病的小胶质细胞自噬体流动
Yi Ding,Shi-Yao Li,Wen-Feng Zhang et al.
Yi Ding et al.
Aberrant metabolic alterations underlie microglial dysfunction, which plays an important role during neurodegenerative progression. However, the role of aberrant glycogen metabolism remains elusive. Here, we identified glycogen accumulation...
Enhanced tumor immunotherapy by nanovesicles derived from engineered DC-like M1 macrophage [0.03%]
由工程_DC样M1巨噬细胞衍生的纳米囊泡增强肿瘤免疫治疗
Linxia Jiang,Yi Yan,Hongqian Xie et al.
Linxia Jiang et al.
To explore a therapeutic approach with dual functions of activating cytotoxic CD8+ T cells and remodeling immunosuppressive tumor-associated macrophages (TAMs), the engineered macrophage-derived nanovesicles (MAC-PNV) were developed in this...
Engineering selective PI3K γ inhibitors with antitumor and immunomodulatory potentials [0.03%]
选择性PI3Kγ抑制剂的工程设计及其抗肿瘤和免疫调节作用
Yi Zuo,Yiru Pu,Jianan Liu et al.
Yi Zuo et al.
PI3Kγ represents a promising therapeutic target for its pivotal role in macrophage recruitment and polarization and its significant association with tumor invasion and metastasis. In this study, a series of novel indole-based PI3Kγ select...