C L Brosnahan,D Warburton,N Cotter et al.
C L Brosnahan et al.
Gastrointestinal nematodes (GIN) remain a major health and productivity challenge for grazing livestock globally, including New Zealand where widespread anthelmintic resistance has been reported. This was a pilot study evaluating the effect...
Ribosomal protein L27 contributes to virulence and maduramicin resistance in Eimeria tenella [0.03%]
里氏杆菌蛋白L27有助于Eimeria tenella的毒力和马杜霉素抗性
Yu Yu,Guo Huilin,Liujia Li et al.
Yu Yu et al.
Coccidiosis, which is primarily caused by Eimeria spp., poses a persistent challenge to poultry health and production worldwide. The emergence and spread of drug-resistant strains have significantly compromised the efficacy of anticoccidial...
Dual-targeting proteasome inhibitor ONX-0914 demonstrates potent antiplasmodial activity for malaria treatment [0.03%]
双靶点蛋白酶体抑制剂ONX-0914可有效治疗疟疾
Nguyen Van Truong,Tuyet-Kha Nguyen,Nguyen Sy Thau et al.
Nguyen Van Truong et al.
There is an urgent need to discover novel antimalarial drugs that are safe and provide effective cures with broad therapeutic potential, novel mechanisms of action, and suitable pharmacokinetic profiles. We studied ONX-0914, which targets t...
Transcriptional responses to in vitro macrocyclic lactone exposure in Toxocara canis larvae using RNA-seq [0.03%]
RNA测序分析密螺旋体犬毒病毒幼虫的体内和体外麦拉酮类药物暴露转录反应
Theresa A Quintana,Matthew T Brewer,Jeba R J Jesudoss Chelladurai
Theresa A Quintana
Toxocara canis, the causative agent of zoonotic toxocariasis in humans, is a parasitic roundworm of canids with a complex life cycle. While macrocyclic lactones (MLs) are successful at treating adult T. canis infections when used at FDA-app...
In vitro antiplasmodial activities of extract and fractions from Lepidobotrys staudtii against sensitive and resistant blood-stage parasites of Plasmodium falciparum [0.03%]
体外抗疟活性研究：勒皮多博特里斯圣德草提取物及组份对抗恶性疟原虫红细胞期敏感和耐药株系的作用
Jeannette Nina Magoudjou Pekam,Noella Molisa Efange,Lakshminarayana Mishro et al.
Jeannette Nina Magoudjou Pekam et al.
Antimalarial resistance is a primary challenge in the treatment of malaria. The ongoing search for novel drug sources remains a critical strategy for addressing this issue. This study evaluated the blood stage antiplasmodial and cytotoxic a...
Faecal egg count reduction test, deep amplicon sequencing of isotype-1 β-tubulin gene and in ovo larval development assay reveal susceptibility to benzimidazoles of porcine nematodes Oesophagostomum spp. and Ascaris suum in outdoor-reared pigs in Germany [0.03%]
粪便虫卵减少试验，同相型-1β-微管基因深度扩增测序以及体内幼虫发育测定揭示德国户外饲养猪的食道口线虫和猪蛔虫对苯并咪唑类药物敏感性
Hannah Rm Fischer,Jürgen Krücken,Stefan Fiedler et al.
Hannah Rm Fischer et al.
Oesophagostomum spp. and Ascaris suum represent the most common porcine nematodes and anthelmintic resistance (AR) to various anthelmintics has been reported for Oesophagostomum. However, the current AR status for worm populations on German...
A novel intron variant is associated with emerging pfdhps mutant haplotypes in West and Central African Plasmodium falciparum [0.03%]
一个新的内含子变异与西非和中非恶性疟原虫新兴pfdhps突变基因型相关
Emma Filtenborg Hocke,Helle Hansson,Ana Chopo-Pizarro et al.
Emma Filtenborg Hocke et al.
Sulfadoxine-pyrimethamine plays a key role in Plasmodium falciparum chemoprevention across Africa, yet the protective efficacy of SP is undermined by mutations conferring resistance in the genes encoding dihydrofolate reductase (pfdhfr) and...
In vitro screening of the open-access Pandemic Response Box reveals ESI-09 as a compound with activity against Echinococcus multilocularis [0.03%]
体外筛选用于应对大流行的开放获取化合物库Pandemic Response Box并发现活性化合物ESI-09对多房棘球蚴具有活性
Pascal Zumstein,Anissa Bartetzko,Marc Kaethner et al.
Pascal Zumstein et al.
Alveolar echinococcosis (AE) is a life-threatening disease caused by the metacestode stage of the fox tapeworm Echinococcus multilocularis, primarily in the liver. Current drug treatments rely on benzimidazoles, which are not parasiticidal,...
Antiplasmodial activity of pentyloxyamide-based histone deacetylase inhibitors against Plasmodium falciparum parasites [0.03%]
基于戊氧胺的组蛋白去乙酰酶抑制剂对恶性疟原虫的抗疟活性
Wisam A Dawood,Gillian M Fisher,Josefa Kremeyer et al.
Wisam A Dawood et al.
Malaria is caused by Plasmodium parasites and remains a significant health concern for almost half the world's population. There are estimated to be > 240 million malaria cases and approximately 600,000 malaria-related deaths annually, main...
Screening and hit evaluation of a microbial metabolite library against the pathogenic Plasmodium falciparum and Toxoplasma gondii parasites [0.03%]
针对致病性恶性疟原虫和刚地弓形虫寄生虫的微生物代谢产物库的筛选与初筛中hit化合物的评估
Maria R Gancheva,Emma Y Mao,Ornella Romeo et al.
Maria R Gancheva et al.
Frontline drug treatments for malaria are at risk of failing due to emerging resistance, meanwhile drugs used to treat toxoplasmosis have suboptimal efficacy and safety. As demonstrated by the success of clinically used antiparasitic drugs,...