Anaphalis margaritacea ethanol extract exhibits potent anti-Trichinella spiralis activity via mitochondrial dysfunction and host tissue protection [0.03%]
蒲公英.marginargarat醋提物通过诱导线粒体功能障碍和保护宿主组织展现对旋毛虫的活性
Xiaoyan Yu,Xinyuan Cao,Yuchao Ma et al.
Xiaoyan Yu et al.
Trichinellosis is a food-borne zoonosis caused by Trichinella spiralis, for which effective treatment against the muscle larvae stage remains limited. To identify new anti-T. spiralis agents from medicinal plants, 30 extracts with reported ...
Screening and evaluation of potential histone deacetylase inhibitors against Babesia infections [0.03%]
巴贝斯虫感染的组蛋白去乙酰化酶抑制剂筛选及评价研究
Xinxin Zhang,Yubin Li,Jin Che et al.
Xinxin Zhang et al.
Babesia spp., a group of blood protozoa transmitted via the bites of tick vectors, cause enormous economic losses for livestock industry and pose significant risk to public health. Currently, the drugs available for treating babesiosis are ...
In vitro profiling of Trypanosoma cruzi inhibitors identified from High throughput Screening and application to parasite painting [0.03%]
基于高通量筛选查尔斯吉氏克雅菌抑制剂的体外分析及其在绘制寄生虫染色中的应用
Kyung-Hwa Baek,Hyeryon Lee,Sooyoung Byun et al.
Kyung-Hwa Baek et al.
Chagas disease, a neglected tropical disease caused by Trypanosoma cruzi, urgently requires next-generation therapeutics due to the limitations of use of benznidazole and nifurtimox, including adverse effects, long treatment period and stil...
Furoxan derivatives with antimalarial activity that disrupt P. falciparum endoplasmic reticulum calcium homeostasis [0.03%]
一类新型硝酮抗疟衍生物及其扰疟原虫内质网钙离子稳态的作用机制研究
Leandro da Costa Clementino,Paula J Bartlett,Guilherme F S Fernandes et al.
Leandro da Costa Clementino et al.
Malaria, caused by Plasmodium spp. parasites, presents treatment challenges due to the emergence of resistant strains to frontline antimalarials. In this study, we explored activities of 24 furoxan derivatives, originally designed for leish...
Unpacking boxes: identification of novel inhibitors of malaria parasite invasion [0.03%]
拆箱行动：疟原虫入侵抑制剂的鉴定
Claudia Bg Barnes,Molly Parkyn Schneider,Olivia D Ventura et al.
Claudia Bg Barnes et al.
With resistance to current frontline antimalarial treatments rapidly emerging in malaria endemic regions, there is an urgent need to identify new antimalarial compounds with novel mechanisms of action. Currently, no clinically used antimala...
In vitro and in vivo anti-piroplasm activity of PBT2 against Theileria annulata and Babesia microti [0.03%]
PBT2体外和体内的抗皮罗孢子虫活性：针对环形泰勒虫和微小巴贝斯虫的研究
Jin Che,Yixuan Wu,Junwei Wang et al.
Jin Che et al.
Theileriosis and babesiosis remain major constraints to livestock production, and increasing drug resistance necessitates alternative therapeutic strategies. Here, we evaluated the metal ionophore PBT2 for anti-piroplasm activity. PBT2 inhi...
A novel 2-piperazino-pyrimidine compound exhibits asexual antimalarial activity by targeting Plasmodium falciparum plasmepsin X [0.03%]
一种新型的2-哌嗪并嘧啶化合物通过靶向Plasmodium falciparum plasmepsin X表现出抗疟活性
Jing Hong,Takaya Sakura,Naoya Asada et al.
Jing Hong et al.
Although the number of cases of malaria has declined since the introduction of artemisinin-based combination therapy in endemic countries, the emergence of resistant parasites in the field has led to an alarming increase in treatment failur...
The detection of three independent benzimidazole resistance mutations in a single Ancylostoma caninum population from a Golden Retriever breeding kennel in Sao Paulo, Brazil [0.03%]
巴西圣保罗一只金毛寻回器繁殖母犬体内独立的三种苯并咪唑抗性突变的检测
Mahya Dini,Rebecca Chen,Elizabeth Redman et al.
Mahya Dini et al.
Multiple anthelmintic drug resistance (MADR) is widespread in the canine hookworm Ancylostoma caninum in kenneled greyhounds in the USA and Australia with benzimidazole resistance being associated with the isotype-1 β-tubulin SNPs Q134H(CA...
Pharmacology and toxicology of veterinary isoxazolines: a review [0.03%]
veterinarium 异唑啉类药物的药理学和毒理学：综述
Paulina Markowska-Buńka,Bartosz Rasiński,Hubert Ziółkowski
Paulina Markowska-Buńka
Isoxazoline derivatives have rapidly become cornerstone ectoparasiticides in veterinary medicine, providing high efficacy and long-lasting protection against fleas, ticks, and other arthropods in companion animals and, more recently, in foo...
Terpenic compounds possess anthelmintic and immunomodulatory properties with potential for controlling equine cyathostomin infections [0.03%]
单萜类化合物具有驱虫和免疫调节作用 有望用于控制马圆线虫属感染
Joshua Malsa,Angélique Chereau,Fabrice Guégnard et al.
Joshua Malsa et al.
The emergence of anthelmintic-resistant parasite isolates necessitates alternative control strategies. The use of dietary additives with anti-parasitic or immunomodulatory activities has been proposed as a solution, but whether such additiv...