Yijia Ji,Joshua P Morrow,Christopher A MacRaild et al.
Yijia Ji et al.
Malaria remains a global health threat, with rising drug resistance accelerating the urgent need for new therapeutics. Target elucidation is a critical step in antimalarial drug discovery, enabling a deeper understanding of the molecular me...
Evaluation of the inhibitory effects of emodin on Neospora caninum invasion and proliferation in vitro [0.03%]
评估大黄酚对犬新孢子虫入侵及增殖的体外抑制作用
Feixue Liu,Jianhua Li,Xin Li et al.
Feixue Liu et al.
The impact of neosporosis on the livestock industry has worsening each year. Globally, annual losses were estimated to exceed $2.4 billion, with abortion rates reaching up to 47 % in affected herds. But no effective vaccines or drugs are cu...
Comparative transcriptomics of naturally susceptible and resistant Trypanosoma cruzi strains in response to Benznidazole [0.03%]
苯硝唑应答的自然易感和抗性克氏锥虫菌株转录组比较分析
Carlos Ospina,Tatiana Cáceres,Stivenn Gutiérrez et al.
Carlos Ospina et al.
Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, remains a major public health challenge due to limited treatment options, Benznidazole and Nifurtimox; which are associated with adverse effects and variable efficacy. The emer...
Recent advances in intestinal helminth parasites of horses in the Asia-Pacific region: Current trends, challenges and future directions [0.03%]
近年来亚洲太平洋地区马肠道线虫寄生虫研究进展：现状、挑战与未来趋势
Ghazanfar Abbas,Martin K Nielsen,Charles E-Hage et al.
Ghazanfar Abbas et al.
Over the past 25 years, significant progress has been made in understanding and managing equine gastrointestinal parasites in the Asia-Pacific region, particularly in Australia and New Zealand. This review synthesises current knowledge of t...
Development of a clinical risk scoring system for artesunate treatment failure prediction in malaria patients [0.03%]
一种临床风险评分系统在疟疾病人中预测 Arteunate 治疗失败的发展
Dasom Kim,Da Hoon Lee,Yubin Song et al.
Dasom Kim et al.
Background: Severe malaria remains a major cause of morbidity and mortality worldwide. Early identification of patients at high risk of poor response to treatment is essential, yet no simple clinical tool is currently ava...
Similar patterns of benzimidazole resistance alleles in ovine gastrointestinal nematodes from Western Canada and Eastern United States supports their shared origins and subsequent spread [0.03%]
来自加拿大西部和美国东部的羊胃肠道线虫中的苯并咪唑耐药等位基因的相似模式支持了其共同起源及其随后的传播
Camila Queiroz,Michel Levy,Russell Avramenko et al.
Camila Queiroz et al.
Livestock movement facilitates translocation of anthelmintic resistant parasites, but the extent to which resistance emergence depends on animal movement is still poorly understood. Benzimidazole resistance is widespread in ovine trichostro...
Illuminating the druggability of the Giardia duodenalis kinome through reannotation and high-throughput screens [0.03%]
通过重新注释和高通量筛选来揭示肠炎弧菌激酶组的可成药性
Alexander Y F Lam,Isabelle S Lucet,Aaron R Jex et al.
Alexander Y F Lam et al.
Giardia duodenalis (syn Giardia intestinalis, Giardia lamblia) is a neglected, microaerophilic gastrointestinal parasite reliant on broad spectrum anti-microaerophilic/-anaerobic nitroheterocyclic antibiotics (metronidazole) which have been...
Challenges in applying W.A.A.V.P. criteria to diagnosing triclabendazole resistance in Fasciola hepatica, an example from the Southern Tablelands of New South Wales, Australia [0.03%]
WAAVP诊断华支睾吸虫对三氯苯达唑耐药性的标准应用难题——澳大利亚新南威尔士州南方高原地区的案例分析
Chelsie Uthayakumar,Hayley Martinez DeCristi,Emily Kate Francis et al.
Chelsie Uthayakumar et al.
Fasciola hepatica (liver fluke) is a zoonotic parasite of global concern. In Australia, it is the 13th most important cause of economic loss in the sheep meat industry alone. Resistance to the frontline drug, triclabendazole (TCBZ), was fir...
Biological and molecular characterisation of in vitro selected miltefosine-resistant Leishmania amazonensis lines [0.03%]
体内筛选的Miltefosine耐药Leishmania amazonensis系的生物和分子特征化
Laura Fernanda Neira,Héllida Marina Costa-Silva,Juliana Martins Ribeiro et al.
Laura Fernanda Neira et al.
Miltefosine (MTF) is currently the only available oral treatment for leishmaniasis. However, increasing reports of therapeutic failure have raised concerns about emerging resistance. This study aimed to investigate the effects of reduced MT...
C L Brosnahan,D Warburton,N Cotter et al.
C L Brosnahan et al.
Gastrointestinal nematodes (GIN) remain a major health and productivity challenge for grazing livestock globally, including New Zealand where widespread anthelmintic resistance has been reported. This was a pilot study evaluating the effect...