P-glycoproteins and amphids: a two-stage trajectory of ivermectin resistance in Caenorhabditis elegans [0.03%]
庞抗蛋白和感觉器官：伊维菌素在秀丽隐杆线虫中耐药性的两阶段发展轨迹
Lucas Barat,Eva Guchen,Clara Blancfuney et al.
Lucas Barat et al.
Ivermectin (IVM) is a cornerstone of nematode control. However, its efficacy is increasingly compromised by emerging resistance in target parasites. P-glycoproteins (Pgps), which mediate drug efflux, and amphid neuron defects, characterized...
A practical miracidial motility assay for assessing Fasciola hepatica sensitivity to compounds in vitro [0.03%]
一种用于评估体外化合物对肝片形吸虫敏感性的真实灯塔素活力测定法
Mengwei Zheng,Aya C Taki,Tanapan Sukee et al.
Mengwei Zheng et al.
Fasciola hepatica causes fasciolosis in livestock and humans worldwide, yet reliable tools to assess drug efficacy against the early developmental stages of this parasite are lacking. Here, we developed an automated miracidial motility assa...
Miloš Lukáč,Martin Pisárčik,Mária Garajová et al.
Miloš Lukáč et al.
Acanthamoebae are opportunistic pathogens causing serious human infections, including granulomatous amoebic encephalitis (GAE) and Acanthamoeba keratitis (AK). The treatment of those infections is limited and difficult to date. Recent resea...
Meclonazepam sensitivity of parasitic flatworms correlates with TRPMMCLZ sensitivity to meclonazepam [0.03%]
麦拉唑敏感的寄生扁虫与TRPMCLZ对麦拉唑敏感性的相关性研究
Claudia M Rohr,Paul McCusker,Marc Kaethner et al.
Claudia M Rohr et al.
The ionotropic portfolio of parasitic flatworms affords considerable opportunity for development of new anthelmintics. In this regard, transient receptor potential ion channels (TRP channels), cation channels responsive to various physioche...
Prevalence of antimalarial drug resistance molecular markers in Makenene, central Cameroon [0.03%]
喀麦隆中部Makenene地区抗疟药物耐药分子标志物的流行率
Nelly Armanda Kala-Chouakeu,Joel Djoufounna,Nicolas Benoit et al.
Nelly Armanda Kala-Chouakeu et al.
Background: Antimalarial drug resistance remains a significant challenge in the fight against malaria in Cameroon. Given the high prevalence of malaria in Makenene in central Cameroon and the limited knowledge of drug res...
Development and evaluation of quadruplex droplet digital PCR assay for rapid detection of molecular markers associated with macrocyclic lactone resistance and susceptibility in Dirofilaria immitis [0.03%]
用于快速检测心丝虫对大环内酯类抗生素抗性和敏感性分子标记物的四重 Droplet Digital PCR 检测试剂盒的开发和评估
Sohini Kumar,Isabelah Kassandra Lalicon,Roger K Prichard et al.
Sohini Kumar et al.
Due to climate change and human interventions, there has been an increase in D. immitis infections, underscoring the necessity for monitoring the spread and extent of resistance. In our prior research, we introduced a rapid test utilizing f...
The EamA metabolite transporter does not affect antileishmanial drug susceptibility [0.03%]
EamA代谢物转运蛋白不影响抗利什曼病药物的敏感性
Rokaya Ahmad,Gaia Gastoldi,Sin-Ting Wong et al.
Rokaya Ahmad et al.
Leishmaniasis is a major neglected tropical disease, exists in 98 countries and constitutes a global public health threat. As chemotherapy is confronted with drug resistance and treatment failure, understanding the underlying mechanisms and...
Anti-cryptosporidial efficacy of tricyclic carbazole aminoalcohols in vitro and in vivo [0.03%]
三环卡巴唑氨基醇类抗隐孢子虫的体内外活性研究
Mingxiao Liu,Weisi Wang,Qi Zheng et al.
Mingxiao Liu et al.
Cryptosporidiosis is a major cause of diarrheal disease in humans and animals, yet there are no fully effective drugs, particularly for immunocompromised patients. Carbazole aminoalcohols (CAAs) are a relatively unexplored chemical class wi...
Ferrostatin-1 alleviates experimental cerebral malaria by regulating immune cell functions and brain endothelial ferroptosis [0.03%]
Ferrostatin-1通过调节免疫细胞功能和脑内皮细胞铁死亡治疗实验性脑疟疾
Shijie Yao,Xiaoliang Zhou,Ting Liao et al.
Shijie Yao et al.
Cerebral malaria (CM), a life-threatening complication of Plasmodium falciparum infection, is characterized by dysregulated immune responses and blood-brain barrier (BBB) damage. In this study, we found that iron metabolic disorders occurre...
Novel heterospirocyclic antimalarials with activity against artemisinin- and multidrug-resistant P. falciparum malaria [0.03%]
具有抗耐青蒿素和多重药物耐药恶性疟活性的新杂螺环类抗疟药
Liana Theodoridis,Carlo Giannangelo,Farrah El-Saafin et al.
Liana Theodoridis et al.
Malaria is an infectious disease that imposes a significant global health burden. Increasing drug resistance creates an urgent demand for novel treatment options. We have previously synthesised a new class of heterospirocyclic compounds wit...