Non-reciprocal callosal projections and input gradients underlie interhemispheric communication in binocular visual cortex [0.03%]
视交叉纤维的非互惠投射和输入梯度构成两眼皮层视觉信息的半球间交流机制
Suraj Honnuraiah,Helena Huang,Elisabetta Furlanis et al.
Suraj Honnuraiah et al.
How the brain combines information received independently by the two hemispheres is not fully understood. Here, we describe a non-reciprocal circuit for interhemispheric communication in the mouse binocular visual cortex via anatomically se...
Microenvironmental TGF-β is an early driver of NF1-associated tumor formation [0.03%]
微环境TGF-β是NF1相关肿瘤形成的早期驱动因素
Alex Power,Salome Stierli,Elizabeth Harford-Wright et al.
Alex Power et al.
Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome characterized by neurofibromas, Nf1-/- Schwann cell (SC)-derived tumors of peripheral nerves. We and others have shown that Nf1 loss in SCs is insufficient for neurofi...
Maturation of hippocampus-medial prefrontal cortex projections defines a pathway-specific sensitive period for cognitive flexibility [0.03%]
海马-内侧前额叶回路发育定义了认知灵活性的路径特异性敏感期
Arely Cruz-Sanchez,Kathleen E LaDouceur,Anusha Abdusalom et al.
Arely Cruz-Sanchez et al.
The septotemporal axis of the hippocampus separates it into domains with unique molecular, cellular, downstream connectivity, and behavioral profiles, and yet very little is known about the ontogenesis of these highly specialized subcircuit...
Angiopoietin-2 aggravates Alzheimer's disease by promoting blood-brain barrier dysfunction and neuroinflammation [0.03%]
血管生成素-2通过促进血脑屏障功能障碍和神经炎症加重阿尔茨海默病
Eunhyeong Lee,Seoyeon Kim,Claire L Zhu et al.
Eunhyeong Lee et al.
Disruption of the blood-brain barrier (BBB) increases vascular permeability and promotes neuroinflammation, contributing to Alzheimer's disease (AD) progression. However, the molecular drivers of BBB dysfunction and neuroinflammation in AD ...
Biophysical modeling identifies an optimal hybrid amoeboid-mesenchymal mechanism for maximal T cell migration speeds [0.03%]
生物物理模型确定了最大化的T细胞迁移速度的最优混合变形虫-间质机制
Roberto Alonso-Matilla,Diego I Pedro,Alfonso Pepe et al.
Roberto Alonso-Matilla et al.
Despite recent advances in cell migration mechanics, the principles governing rapid T cell movement remain unclear. Efficient migration is critical for antitumoral T cells to locate and eliminate cancer cells. To investigate the upper limit...
Cryo-EM structures of antibodies elicited by germline-targeting HIV MPER epitope scaffolds [0.03%]
针对HIV MPER表位支架诱导的抗体的冷冻电镜结构
Jiachen Huang,Olivia M Swanson,Kimmo Rantalainen et al.
Jiachen Huang et al.
Applying cryoelectron microscopy (cryo-EM) to small protein complexes is usually challenging due to their lack of features for particle alignment. Here, we characterized antibody responses to 21 kDa human immunodeficiency virus (HIV) membra...
A phosphohistidine phosphatase promotes starvation survival by dephosphorylating nucleoside diphosphate kinase [0.03%]
一种磷酸组氨酸磷酸酶通过去磷酰化核苷二磷酸激酶以促进饥饿生存
Akash R Sinha,Mark Goulian
Akash R Sinha
Nucleoside diphosphate kinase (Ndk) is a ubiquitous enzyme that maintains the cellular nucleoside triphosphate (NTP) pool and participates in many other pathways of eukaryotes and prokaryotes. Here, we show that in Escherichia coli, Ndk is ...
Mapping the functional connectome of the claustrum: Noise filtering via local inhibitory circuits [0.03%]
通过局部抑制性环路滤除噪声：类体膜功能连接组的构图研究
Martin Graf,Sadra Sadeh,George J Augustine
Martin Graf
We optogenetically mapped the function and spatial organization of inhibitory circuits formed by interneurons (INs) within the claustrum, a highly interconnected but poorly understood brain region. INs expressing parvalbumin or somatostatin...
Single-cell multiome and enhancer connectome of human retinal pigment epithelium and choroid nominate causal variants in macular degeneration [0.03%]
人视网膜色素上皮和脉络膜的单细胞多组学和增强子连接体，以及黄斑变性位点的因果变异提名
Sean K Wang,Jiaying Li,Surag Nair et al.
Sean K Wang et al.
Age-related macular degeneration (AMD) is a leading cause of vision loss worldwide. Genome-wide association studies (GWASs) of AMD have identified dozens of risk loci that may house disease targets. However, variants at these loci are large...
PDX1 phosphorylation at S61 by mTORC1 links nutrient signaling to β cell function and metabolic disease [0.03%]
营养信号转导通路中的PDX1的S61位点由mTORC1磷酸化链接至β细胞功能及代谢性疾病中
Jialin Fan,Xin Zhang,Jinling Zhang et al.
Jialin Fan et al.
PDX1 is a key transcription factor regulating insulin expression in response to glucose. Our previous work showed that PDX1 is also stimulated by amino acids (aa). Here, we demonstrate that PDX1 broadly mediates aa-regulated transcriptional...