GABAergic interneuron subtypes differentially regulate noise correlations that are critical for visual orientation discrimination in mice [0.03%]
不同类型的GABA能中间神经元对小鼠视觉方向辨别中关键的噪声相关性有差异化调节作用
Guangwei Xu,Xiaoming Liu,Jiachen Liu et al.
Guangwei Xu et al.
Noise correlations-synchronized firing fluctuations among neurons-critically influence sensory processing, yet their regulatory mechanisms remain unclear. We investigated how V1 inhibitory neuron subtypes regulate noise correlations and vis...
Lauren N Dunn,Brian F Niemeyer,Neetha P Eduthan et al.
Lauren N Dunn et al.
Trisomy 21 (T21) gives rise to Down syndrome (DS), the most commonly occurring chromosomal abnormality in humans. T21 affects nearly every organ and tissue system in the body, predisposing individuals with DS to congenital heart defects, au...
Redefining the role of chaperones for Dot/Icm T4BSS-mediated substrate translocation by Legionella pneumophila [0.03%]
Legionella pneumophila通过Dot/Icm T4BSS介导的底物转运重新定义伴侣蛋白的作用
Sukhithasri Vijayrajratnam,Ahmet Hasanovic,Joseph P Vogel
Sukhithasri Vijayrajratnam
Legionella pneumophila, the etiological agent of legionnaires' disease, establishes its intracellular niche through the Dot/Icm type IVB secretion system, which translocates ∼300 effector proteins into host cells. Efficient secretion of ma...
Surround motion modulates the encoding properties of primate retinal ganglion cells [0.03%]
环绕运动调节灵长类视网膜节细胞的编码属性
Todd R Appleby,Fred Rieke,Michael B Manookin
Todd R Appleby
Antagonistic interactions between center and surround regions of the receptive field are widely observed across sensory systems. In the early visual system, these interactions contribute to important computations such as edge detection. How...
In situ multi-modal characterization of pancreatic cancer reveals tumor cell identity as a defining factor of the surrounding microenvironment [0.03%]
原位多模式表征胰腺癌揭示肿瘤细胞身份是周围微环境定义因素
Anna Lyubetskaya,Brian Rabe,Andrew Kavran et al.
Anna Lyubetskaya et al.
Pancreatic ductal adenocarcinoma is heterogeneous, with low tumor purity, a prominent microenvironment, and complex architecture, which preclude the identification of shared tumor-intrinsic and stromal biology within and across patients. We...
Differentiation in the human urothelia is defined by distinct alternative polyadenylation [0.03%]
人类尿路上皮分化由特定的可变多腺苷酸化定义
Ninh B Le,Surbhi Sona,Briana Santo et al.
Ninh B Le et al.
Distinct epithelial cell states arise during differentiation, but mechanisms generating transcriptomic diversity among them remain poorly defined. The human ureter urothelium contains basal progenitor, intermediate cells, and terminally dif...
Fibroblast-derived alarmin promotes oral wound healing by activating regulatory T cells that relay pro-angiogenic and anti-inflammatory responses [0.03%]
成纤维细胞源性警报素通过激活调节性T细胞促进口腔伤口愈合该通路可传递促血管生成和抗炎信号
Zhaoxu Chen,Zikeng Huang,William S Kim et al.
Zhaoxu Chen et al.
Fibroblasts are abundant structural cells with an emerging immune-sentinel role in the wound healing process, though its functional significance remains incompletely explored. By utilizing an oral injury model that heals rapidly, we identif...
NFAT mediates pro-tumorigenic inflammation in cancer-associated fibroblasts in pancreatic ductal adenocarcinoma [0.03%]
活化的癌相关成纤维细胞通过NFAT通路促进胰腺导管腺癌炎症反应及肿瘤发生发展
Chuner Guo,Michelle F Griffin,Annah G Morgan et al.
Chuner Guo et al.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense stroma, low immunogenicity, and resistance to therapy. Cancer-associated fibroblasts (CAFs) are key stromal cells within the tumor microenvironment (TME) that drive tumor p...
Genomic divergence and sex-linked region of Welwitschia mirabilis revealed by whole-genome re-sequencing [0.03%]
Welwitschia mirabilis全基因组重测序揭示其基因组分歧和性连锁区域
Jing-Jing Sun,Xiao-Mei Xia,Chang Liu et al.
Jing-Jing Sun et al.
A central goal of population genomics is to unveil the evolutionary forces driving genomic divergence. Although genomic islands have been extensively studied in angiosperms, the patterns of genomic divergence remain poorly understood in gym...
Expression dynamics of functionally equivalent Neurog1/2 genes enable protracted neurogenesis and temporal emergence of somatosensory neuron lineages [0.03%]
功能等效的Neurog1/2基因的表达动力学使感觉神经元得以长期发育并按时间顺序出现不同的亚型
Simon Desiderio,Pauline Cabochette,Stephanie Venteo et al.
Simon Desiderio et al.
Dorsal root ganglia (DRG) somatosensory neurons of the mechano/proprioceptive and thermo/nociceptive lineages differentiate during successive neurogenic waves defined by the complementary expression and combinatorial roles of the proneural ...